Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-methoxy-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP3 --- MMP8 | 2-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophene-2-sulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-bromophenyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 15-benzyl-16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-3-cyclopentylpropanamide | Drug Info |
| Ftase --- FPTase | (S)-2-({(S)-2-[2-(2-Mercapto-ethylamino)-acetyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-thiophen-2-ylurea | Drug Info |
| VEGFR2 --- CSrc | Benzofuran-4-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3-Bromo-10-methoxy-8-methyl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(oxetan-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | (+)-1-((1R,3R)-3-hydroxycyclopentyl)-3-(4-methoxyphenyl)-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(3,5-Difluoro-benzyloxy)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 5-(6-morpholino-9-(piperidin-4-yl)-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| VEGFR2 --- FGFR1 | N-[2-(3-tert-Butyl-ureido)-3-(3,5-dimethoxy-phenyl)-3,4-dihydro-[1,6]naphthyridin-7-yl]-N-(4-hydroxy-butyl)-acetamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea | Drug Info |
| VEGFR2 --- HDAC1 | N2-(2-aminophenyl)-N5-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2,5-dicarboxamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methanesulfonyl-benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 1-(4-Chlorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(5-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)-1-oxo-2-pyridyloxy)-1H-benzimidazol-2-yl)-carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(6-oxo-heptanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| NET --- SERT | cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-(4-nitrobenzyl)amine | Drug Info |
| VEGFR2 --- TEK | N-[19-methyl-3-(2-methylpropyl)-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl]furan-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| NET --- SERT | 4-(4-Fluoro-indan-2-ylmethyl)-4,5-dihydro-1H-imidazole | Drug Info |
| VEGFR2 --- TEK | 1-(2-fluoro-5-methylphenyl)-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(propan-2-yl)-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']terphenyl-3-carboxylic acid 22 (FTI-2195) | Drug Info |
| NPKCdelta --- NPKCtheta | Octanoic acid (E)-(1S,5S,9S,11S,15R,19R,24S)-11-tert-butyl-1,15-dihydroxy-19-((R)-1-hydroxy-ethyl)-23-methoxycarbonylmethylene-2,2-dimethyl-17-oxo-6,12,18,25,26-pentaoxa-tricyclo[19.3.1.1*5,9*]hexacos-3-en-24-yl ester | Drug Info |
| VEGFR2 --- TEK | N-(4-phenoxyphenyl)-3-(3-(4-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-yl)pyridin-2-ylamino)benzamide | Drug Info |
| Ftase --- FPTase | 4-(3,3-dimethylbutyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[(3S)-3-Aminopyrrolidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(1H-pyrrol-1-yl)benzamide | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-4-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(4-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| Ftase --- FPTase | 5-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-5-oxo-pentanoic acid | Drug Info |
| CAII --- CAI | 4-(Heptadecafluorooctane-1-sulfonylamino)-3-iodo-benzenesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(3-((dimethylamino)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | (1H-indazol-3-yl)(2-(quinolin-6-ylmethylamino)phenyl)methanone | Drug Info |
| H3 --- SERT | 2-methyl-4-phenyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(1-(3-fluorophenylsulfonyl)-1H-indazol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | GW631581B | Drug Info |
| H3 --- SERT | N-(4-(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)but-3-ynyl)-N-methylcyclopropanamine | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-2-dimethylaminomethyl-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645108 | Drug Info |
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