Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PKCA --- NPKC delta | 4-(2-Ethoxycarbonyl-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2,5-Difluoro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-(4-bromophenyl)acrylate | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (2R,3R)-3-(4-hydroxy-benzoylamino)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester | Drug Info |
| HDAC1 --- HD6 | 2-(3-Benzenesulfonylamino-phenyl)-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)furan-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | tyrphostin AG-825 | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| HDAC1 --- HD6 | (5S,8R,11S,13aR)-5-sec-Butyl-8-(4-methoxy-benzyl)-11-(7,7,8,8,8-pentafluoro-6-oxo-octyl)-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(3-chloro-4-fluorophenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(4-(3-chlorobenzyloxy)-3-chlorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(3',4'-dichloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HD6 | Octanedioic Acid-{3-[1-(3,5-Difluorophenyl)-1H-[1,2,3]triazol-4-yl]phenyl}amide-Hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-4-methyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| EGFR3 --- MCSF | (2,3-Dihydro-1H-indol-2-yl)-(6,7-dimethoxy-quinazolin-4-yl)-amine; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methoxybiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-aminophenyl)-4-(((benzo[d][1,3]dioxol-5-ylmethyl)(2-hydroxyethyl)amino)methyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(Trifluoromethyl)-3,9-dihydropyrrolo[2,3-b]carbazol-2(1H)-one | Drug Info |
| Erbeta --- ER | (S)-2-((1R)-1-hydroxy-5,8-dimethyl-7-(pyridin-3-ylmethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-(2-morpholinoethyl)propanamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-(4-(4-(1,3-dioxoisoindolin-2-yl)-2-methoxyphenethyl)benzyl)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-4-(2,5-difluorophenyl)-2-(3-(ethylamino)propyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Erbeta --- ER | 4-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)-N,N-dimethylbenzamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2,4,6-trimethylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 5-Trifluoromethoxy-1H-indole-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| DHFR --- VEGFR | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Erbeta --- ER | 7-hydroxy-3-(4-hydroxyphenyl)-5-methyl-3H-quinazolin-4-one | Drug Info |
| PPAR gamma --- PPAR delta | rac-2-(4-Methoxy-3-((4-phenoxybenzamido)methyl)benzyl)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-(4-Bromobenzyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Src --- VEGFR | [6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-(4-methoxy-phenyl)-amine | Drug Info |
| Erbeta --- ER | 9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-ylethoxy)phenyl]-1,2,9,9a-tetrahydro-3H-fluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[4-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenoxy}-propionic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-1-tert-butyl-3-[1-(cyclopentylamino)-7-mercapto-1-oxoheptan-2-yl)thiourea | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| Erbeta --- ER | 7-Ethyl-4-methyl-9-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-9,10-dihydro-phenanthren-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(benzo[d]isoxazol-3-yl)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| HER2 --- CD221 | N-(4-(4-amino-1-(1'-isopropyl-1,4'-bipiperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| VEGFR2 --- AuroraA | N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | Drug Info |
| Erbeta --- ER | (1S,12R)-5-hydroxy-10-methyltetracyclo[10.2.1.0^{1,9}.0^{3,8}]pentadeca-3(8),4,6,9-tetraen-11-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(1,2,3,4-Tetrahydro-quinolin-7-yloxy)-ethoxy]-benzyl}-malonic acid monomethyl ester | Drug Info |
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Erbeta --- ER | 7-Phenyl-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-chloro-4-(3-(3-hydroxy-4-(1-(hydroxyimino)propyl)-2-propylphenoxy)propylthio)phenyl)acetic acid | Drug Info |
| JNK1 --- JNK3 | 2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triazol-5-yl)thiazol-5-yl)acetamide | Drug Info |
| VEGFR2 --- CDK1 | 4-(5-cyano-2-(4-(2-hydroxyethyl)phenylamino)pyrimidin-4-yl)benzenesulfonamide | Drug Info |
| Erbeta --- ER | 4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | 4-bromo-2-(3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(thiazol-2-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
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