Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) | Drug Info |
| Erbeta --- ER | 2-(6-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(prop-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC4 | N1-(2-(hydroxycarbamoyl)phenyl)-N8-phenyloctanediamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-3-(4-hydroxyphenyl)-5-methylquinazoline-4(3H)-thione | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-chloro-2-phenoxyphenoxy)butoxy)-2-(trifluoromethyl)phenyl)propanoic acid | Drug Info |
| HER2 --- CD221 | N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-[4-(1-methyl-piperidin-4-yl)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-(N-Isopropyl-N-methyl)benzamide)-5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| IKKbeta --- JAK2 | N-(2-aminoethyl)-4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N-methylbenzamide | Drug Info |
| Erbeta --- ER | 4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((5-(4-isopropylphenyl)-1-methyl-1H-pyrazole-3-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-(5-hydroxypent-3-en-1-ynyl)picolinamide | Drug Info |
| Erbeta --- ER | (5,6-dihydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| PPAR gamma --- PPAR delta | 3-{4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(thiazol-2-yl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | 1-[6-Hydroxy-2-(4-hydroxy-phenyl)-quinolin-4-yl]-ethanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(1-(3-methoxybenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-(trifluoromethoxy)phenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | SID17385432 | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-{[(5-biphenyl-4-yl-1-methyl-1H-pyrazole-3-carbonyl)-amino]-methyl}-2-methyl-phenoxy)-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylmethoxy)picolinamide | Drug Info |
| Erbeta --- ER | 3'-(methylamino)-1,1':2',1''-terphenyl-4'-carbaldehyde oxime | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(2-methyl-4-(3-(2-phenoxy-4-(trifluoromethoxy)phenoxy)butoxy)phenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | Geldanamycin | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinoxalin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| JNK1 --- JNK3 | 4-(9-cyclopentyl-8-(2-fluorophenylamino)-9H-purin-2-ylamino)cyclohexanol | Drug Info |
| PPAR gamma --- PPAR delta | 2-[3-(3-{(2-Cyclopropyl-3-[1,2,4]oxadiazol-3-yl-phenyl)-[2-(3,4-dichloro-phenoxy)-acetyl]-amino}-propyl)-phenoxy]-2-methyl-propionic acid | Drug Info |
| Erbeta --- ER | 4-(2-(2-chlorophenyl)-1H-benzo[d]imidazol-1-yl)phenol | Drug Info |
| JNK1 --- JNK3 | 5-fluoro-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-methoxy-3-(4-(4-(4-phenoxyphenoxy)but-1-ynyl)phenyl)propanoic acid | Drug Info |
| Erbeta --- ER | SID859273 | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(3-fluoroquinolin-5-yl)acetamide | Drug Info |
| PR --- mRNA of AR | (S)-3-(3-Bromo-4-hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide | Drug Info |
| Erbeta --- ER | SID50112959 | Drug Info |
| MEP --- Cathepsin B | 1-(1-(3,5-bis(trifluoromethyl)phenyl)-3-phenylpropylidene)thiosemicarbazide | Drug Info |
| PR --- mRNA of AR | 2-chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-methylbenzonitrile | Drug Info |
| Erbeta --- ER | 4-bromo-6-hydroxy-2-(4-hydroxyphenyl)isoindoline-1,3-dione | Drug Info |
| MEP --- Cathepsin B | {3-Methyl-1-[2-oxo-1-phenethyl-3-(3-phenyl-propylsulfanyl)-propylcarbamoyl]-butyl}-carbamic acid pyridin-3-ylmethyl ester | Drug Info |
| PR --- mRNA of AR | 5-(3,3-Difluoro-allyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 1-{2-[4-((3S,4R)-7-Methoxy-3-phenyl-isochroman-4-yl)-phenoxy]-ethyl}-pyrrolidine | Drug Info |
| MEP --- Cathepsin B | 2-(4-Bromo-thiophen-3-ylamino)-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| PR --- mRNA of AR | Acetic acid 5-bromo-2-((1S,6R)-4,6-dimethyl-2-methylene-cyclohex-3-enylmethyl)-4-methoxy-phenyl ester | Drug Info |
| Erbeta --- ER | (S)(-)-9a-Butyl-6-ethyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| MEP --- Cathepsin B | 1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-phenylethylamino)-4-fluoro-4-methyl-1-oxopentan-2-ylamino)-2,2,2-trifluoroethyl)biphenyl-4-yl)cyclopropanecarboxamide | Drug Info |
| PR --- mRNA of AR | N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1H-indol-7-yl)methanesulfonamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(9-Aza-bicyclo[3.3.1]non-9-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-(pyridin-4-yl)ethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide | Drug Info |
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