Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)propyl)-4-methylbenzamide | Drug Info |
| MMP2 --- MMP13 | (S)-4-(4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamido)-N-methylpiperidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(3-methoxy-phenoxy)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(1,1,2-triphenylethylthio)ethanamine | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(N-isobutylnaphthalene-2-sulfonamido)acetamide | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[2-(3H-Imidazol-4-yl)-ethylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2,2-dimethylpropan-1-one | Drug Info |
| MMP2 --- MMP13 | (S)-N-(1-(cyclopropanecarbonyl)piperidin-4-yl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| Ftase --- FPTase | 4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-acetyl-4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-cyano-N'-(1-oxy-pyridin-3-ylmethyl)-piperidine-1-carboxamidine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-4-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(4-acetylpiperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(3-imidazol-1-yl-propyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-(3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)butyl)-1H-imidazole-4-carboxamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-formyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-methoxyphenethyl)quinoline-2-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 8-(Trifluoromethyl)-3,4-dihydro-1H-pyrido[3,2-b]carbazol-2(6H)-one | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2-fluoro-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[7-(Trifluoromethyl)-9H-carbazol-2-yl]urea | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(cyclopentylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | (20R)-14-chloro-19,20,21,22-tetrahydro-19-oxo-17H-18,20-etheno-6,10:12,16-dimetheno-16H-imidazo[3,4-h][1,8,11,14]oxatriazacycloeicosine-9-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829408 | Drug Info |
| MMP2 --- MMP3 | (R)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea | Drug Info |
| Ftase --- FPTase | 2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxyphenyl)-8-methoxy-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzoylamino-benzenesulfonylamino)-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-pyridin-3-yl-propan-1-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-((3R,3aR)-2-acetyl-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-3-yl)-propyl]-4-methyl-[1,4]diazepan-5-one | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenylethynyl-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[Butyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2''-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-4-methyl-N-(1-(4-oxo-3-(pyridin-4-ylmethyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzamide | Drug Info |
| MMP2 --- MMP9 | 3-Benzyl-4-oxo-4-((4-phenylethynyl)phenyl)butyric acid | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-[(4-cyano-3-fluoro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-biphenyl-3-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID99356130 | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-4-(pyridin-4-yloxy)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | {2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829416 | Drug Info |
| MMP2 --- MMP9 | (R)-2-Biphenyl-4-ylmethyl-N*4*-hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-succinamide | Drug Info |
| Ftase --- FPTase | 1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-pyrrol-1-yl-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(thiazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| MMP2 --- MMP9 | 4-Benzylsulfanyl-2-[[(cyclohexylmethyl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-butyramide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butylamide | Drug Info |
| Ftase --- FPTase | 2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Lck --- VEGFR | 6-Bromo-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-2-ylmethyl-acetamide | Drug Info |
| Src --- VEGFR | N-1,3-benzodioxol-4-yl-7-(3-pyrrolidin-1-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
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