Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- FGFR1 | N-(3-Benzyloxy-propyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| Erbeta --- ER | 4-(5-hydroxybenzo[d]oxazol-2-yl)benzene-1,3-diol | Drug Info |
| PPAR gamma --- PPAR delta | rac-2-{3-[(4-adamantan-1-yl-benzoylamino)-methyl]-4-ethoxy-benzyl}-butyric acid | Drug Info |
| JNK1 --- JNK3 | methyl 4-methyl-2-(2-(quinoxalin-5-yl)acetamido)thiophene-3-carboxylate | Drug Info |
| VEGFR2 --- HER2 | 6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| Erbeta --- ER | 4-{(2R,3S)-2-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-3-yl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-(2-(5-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)ethoxy)phenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 5-bromo-N-(3-chloro-2-(4-phenethylpiperazin-1-yl)phenyl)furan-2-carboxamide | Drug Info |
| VEGFR2 --- TEK | (R)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide | Drug Info |
| Erbeta --- ER | SID4256516 | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dichlorophenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-(4-hydroxybut-1-ynyl)picolinamide | Drug Info |
| VEGFR2 --- TEK | 4-fluorophenyl N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}carbamate | Drug Info |
| Erbeta --- ER | 4,6,7-trimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| JNK1 --- JNK3 | 3-(2-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)phenylamino)pyrimidin-4-yl)-5-morpholinobenzonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea | Drug Info |
| Erbeta --- ER | N-[3-((R)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-propyl]-2-iodo-acetamide | Drug Info |
| JNK1 --- JNK3 | (2-Chloro-phenyl)-(3-phenyl-1H-indazol-6-yl)-amine | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-(trifluoromethyl)phenyl)aminothiocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Erbeta --- ER | 3-(3-Fluoro-4-hydroxy-phenyl)-7-hydroxy-naphthalene-1-carbaldehyde | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-cyano-2-oxoquinolin-1(2H)-yl)acetamide | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-3a-aza-2-indolyl)carbamate | Drug Info |
| Erbeta --- ER | 7-Bromo-2-(2-fluoro-4-hydroxy-phenyl)-benzooxazol-5-ol | Drug Info |
| JNK3 --- MAPK | 1-[(S)-2-Benzyl-4-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)-piperazin-1-yl]-2-hydroxy-ethanone | Drug Info |
| VEGFR2 --- TEK | 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide | Drug Info |
| Erbeta --- ER | 4-{(E)-1-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-hept-1-enyl}-phenol | Drug Info |
| MEP --- Cathepsin B | (1S,2S)-2-bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one | Drug Info |
| VEGFR2 --- VEGFR1 | (3-Fluoro-5-trifluoromethyl-phenyl)-(4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine | Drug Info |
| Erbeta --- ER | (R)-1-(2-{4-[(2S,3R)-6-Hydroxy-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-2-yl]-phenoxy}-ethyl)-pyrrolidin-3-ol | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-1-oxo-3-(3-(pyridin-4-yl)phenyl)propan-2-yl)benzamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-bromophenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-2-phenoxy-ethanone | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-N-(4-methyl-3-(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| Erbeta --- ER | (6S,6aR,10aS)-6-(4-hydroxyphenyl)-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-2-ol | Drug Info |
| MEP --- Cathepsin B | (R)-3-(2,3-difluorobenzylsulfonyl)-N-(1-cyanocyclopropyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamide | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Erbeta --- ER | 2-butyl-5,7-dihydroxy-3-(4-hydroxyphenyl)-3H-quinazolin-4-one | Drug Info |
| Met --- VEGFR | N1-(3-fluoro-4-(2-(pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-azido-N-(2-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethoxy)ethyl)-2,3,5,6-tetrafluorobenzamide | Drug Info |
| Erbeta --- ER | 2-phenyl-1,2'-spirobi[1H-indene]-5'-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-2-carboxamide | Drug Info |
| Erbeta --- ER | epi-phelligrin A | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(benzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| Erbeta --- ER | 3,5-dichloro-3'-fluoro-4'-hydroxy-biphenyl-4-carbaldehyde oxime | Drug Info |
| MMP1 --- MMP3 | (R)-2-[4-(4-Chloro-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-phenethylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(quinolin-4-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)isothiazole-3-carboxamide | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-1-(4-(2-(piperidin-1-yl)ethoxy)benzoyl)-1H-indol-3-yl)acetamide | Drug Info |
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