Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HDAC1 --- HD6 | 2-(4-Methoxyphenyl)-2-oxoethyl Dithiobutyrate | Drug Info |
| EGFR3 --- HER2 | 4-Diisopropylamino-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(3-(trifluoromethyl)phenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 2-[4-(4-Chloro-phenylsulfamoyl)-phenyl]-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 2-(3-(4-Bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{5-[(2-Phenoxy-ethylcarbamoyl)-methyl]-thiophen-2-yl}-ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidin-5-yl)-2-methyl-N-(2-morpholinoethyl)acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2,3-dimethyl-4-(2-(2-morpholinoethoxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)phenoxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-aminophenyl)nicotinamide | Drug Info |
| ER --- PR | N-(7-Bromo-1-methoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-aminobiphenyl-3-yl)benzamide | Drug Info |
| Erbeta --- ER | 5-chloro-2-(4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | rac-2-(4-Methoxy-3-((3-phenoxybenzamido)methyl)benzyl)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | [4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-naphthalen-1-yl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(2,4'-dimethylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 1-(4-Fluoro-phenyl)-1H-indole-3-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | 3-(4'-Hydroxyphenyl)Coumarin | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(3-((6-chloro-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | 6-((5S,8S,11S,13aR)-5,8-Dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanoic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-[4-(4-isopropyl-piperazin-1-yl)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-{5-[(4-Adamantan-1-yl-2-fluoro-benzoylamino)-methyl]-2-fluoro-4-propoxy-benzyl}-butyric acid | Drug Info |
| HER2 --- CD221 | trans-2-(4-(4-(4-amino-3-(4-(7-chlorobenzo[d]oxazol-2-ylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazin-1-yl)-N,N-dimethylacetamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-nitro-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-chloro-2-phenoxyphenoxy)butoxy)-2-ethylphenyl)propanoic acid | Drug Info |
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-((R)-3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid | Drug Info |
| JAK2 --- STK1 | SID103904526 | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-o-tolyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethoxyphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 5-chloro-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | 4,4'-(but-3-yne-1,2-diyl)diphenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-ethoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenylmethyl}butyric acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (3aR,4S,9bS)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-Isopropoxy-3-{4-[5-(4-isopropyl-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-chlorophenyl)-6-methylpicolinamide | Drug Info |
| Erbeta --- ER | 3-(3-chloro-4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxopyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-{4-[(S)-2-((S)-3-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-chroman-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(2-methyl-4'-(trifluoromethoxy)biphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-acetylpiperazin-1-yl)-3-chlorophenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | (2R,3S)-7-Chloro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 9-ethyl-N8-(2-fluorophenyl)-N2-(4-methoxyphenyl)-9H-purine-2,8-diamine | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-6-(ethoxymethyl)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
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