Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(3-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP13 --- MMP14 | (2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)-4-((R)-2-(3-chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxobutanamide | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-pyridin-4-ylmethyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(3-chloro-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | 5-hydroxy-2-(4-hydroxyphenyl)benzo[d]oxazole-7-carbaldehyde | Drug Info |
| MMP13 --- MMP9 | 2-[(4'-Benzyloxy-biphenyl-4-sulfonyl)-methyl-amino]-5-bromo-N-hydroxy-3-methyl-benzamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(2-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| Erbeta --- Mcl1 | SID7969281 | Drug Info |
| MMP2 --- MMP13 | 2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesulfonyl)-propionamide | Drug Info |
| Ftase --- FPTase | 2-alpha,24,25-trihydroxylanostan-3-one | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2-chlorophenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Bis-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (1H-imidazol-2-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(2-methoxyphenyl)piperazin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(Biphenyl-4-ylmethylsulfanyl)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-1-(isopropylsulfonyl)-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(4-hydroxy-2-methylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP14 | (S)-2-{4'-[(5-Methoxy-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-oxazolo[5,4,3-ij]quinolin-4-one | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-naphthalen-2-yl-phenyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | [((2E,6E,10E)-3,7,11,15-Tetramethyl-hexadeca-2,6,10,14-tetraenyloxycarbamoyl)-methyl]-phosphonic acid | Drug Info |
| MMP2 --- MMP3 | (R)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-2-[3-(2-methoxy-biphenyl-4-yl)-propyl]-succinamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-(2-phenylpropan-2-ylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropylamino)-3-methylbutoxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoic acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(4-Benzyl-phenyl)-2-butyl-4-((S)-2,2-dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid methyl ester | Drug Info |
| MMP2 --- MMP9 | N-benzyl-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-butyl-piperazin-1-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 3-vFPP | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethynyl)-thiophene-2-sulfonylamino]-propionic acid | Drug Info |
| PPAR gamma --- PPAR delta | 3-{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| Ftase --- FPTase | 7-alGGPP | Drug Info |
| MMP2 --- MMP9 | (2R)-[(4-biphenylylsulfonyl) amino]-N-hydroxy-3-phenylpropionamide | Drug Info |
| PR --- mRNA of AR | 5-Bromo-2-((1S,5R)-5-hydroxy-2,2,5-trimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[b]thiophene-2-carboxamide | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(3-methoxyphenylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| PR --- mRNA of AR | 5-Bromo-4-methoxy-2-((1R,2S)-2-methyl-6-methylene-cyclohexylmethyl)-phenol | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-2-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(quinoxaline-2-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-phenylpropan-1-one | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(3-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-methyl-4-(4-(trifluoromethyl)phenoxy)benzenesulfonamide | Drug Info |
| PR --- mRNA of AR | (R)-3-(4-Hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)-propanamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-2-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
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