Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HER2 --- CD221 | cis-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chloro-5-methylbenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | 9a-butyl-6-propyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(Naphthalen-2-yloxy)-ethoxy]-benzyl}-malonic acid monomethyl ester | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-propyl-2H-benzo[1,4]oxazin-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-(4-(4-fluorophenoxy)benzylcarbamoyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-phenylquinazolin-2-amine | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-6-(2-(piperidin-1-yl)ethoxy)-1H-indol-3-yl)acetamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-Ethoxy-3-[4-((E)-5-phenyl-pent-2-en-4-ynyloxy)-phenyl]-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-methoxyethyl)-3-(2-phenylacetamido)thiophene-2-carboxamide | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{3-[(4-Adamantan-1-yl-benzoylamino)-methyl]-5-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
| JNK1 --- JNK3 | trans-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-4-methoxycyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-4-vinylquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-((Piperidin-1-yl)methanone)phenyl)-5-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| JNK1 --- JNK3 | 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | (E)-3-[4-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-phenyl]-N,N-dimethyl-acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(4-methoxybut-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-benzylpiperazin-1-yl)-3-chlorophenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | 6-(4-hydroxy-3-methoxyphenyl)naphthalen-1-ol | Drug Info |
| Erbeta --- ER | 2-(naphthalen-1-yl)benzo[d]oxazol-6-ol | Drug Info |
| JNK1 --- JNK3 | N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol | Drug Info |
| JNK1 --- JNK3 | 4-(5-(naphthalen-2-yl)-1H-pyrazol-4-yl)pyridine | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(2-benzoyl-4-ethylphenoxy)pentyloxy)-2-methylphenyl)propanoic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 4-(3-Fluoro-5-morpholinophenyl)-N-(4-(3-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-[4-[5-(3,4-dichloro-phenyl)-[1,2,4]thiadiazol-3-ylmethylsulfanyl]-2-methyl-phenoxy}-2-methyl-propionic acid | Drug Info |
| Erbeta --- ER | 4-((1R,2R,5R)-5-Hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-2-methyl-phenol | Drug Info |
| JNK1 --- JNK3 | methyl 4-(2-(naphthalen-1-yl)acetamido)-1H-pyrazole-3-carboxylate | Drug Info |
| PR --- mRNA of AR | (R)-5-bromo-2-((2,2-dimethyl-6-methylenecyclohexyl)methyl)-4-methoxyphenol | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | [(S)-1-(1-Isobutyl-2,5-dioxo-piperidin-4-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| PR --- mRNA of AR | racemic-5-chloro-6-(6-methoxy-1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline | Drug Info |
| Erbeta --- ER | (2S)-2,3-bis(4-hydroxyphenyl)succinonitrile | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-1-oxo-3-(3-(pyridazin-3-yl)phenyl)propan-2-yl)benzamide | Drug Info |
| PR --- mRNA of AR | (5bR,9aR)-1-Ethyl-4-trifluoromethyl-1,5b,6,7,8,9,9a,10-octahydro-pyrido[2,3-b]carbazol-2-one | Drug Info |
| Erbeta --- ER | 6-(3-fluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol | Drug Info |
| MEP --- Cathepsin B | 2-(1-(3-chlorophenyl)-3-phenylpropylidene)hydrazinecarbothioamide | Drug Info |
| PR --- mRNA of AR | 4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-furan-2-carbonitrile | Drug Info |
| Erbeta --- ER | 4-{5-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydrobenzo[b]oxepin-4-yl}-phenol | Drug Info |
| MEP --- Cathepsin B | N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diphenylacetamido)propanamide | Drug Info |
| PR --- mRNA of AR | (Z)-5-(2'-(3'-hydroxymethylthienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 4-{2-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propoxy)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| Met --- VEGFR | N-(4-(2-(4-((2-(dimethylamino)ethyl)(methyl)carbamoyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Methoxyphenylamino)-3-phenyl-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| PR --- mRNA of AR | 5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 1-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-4-yl)phenoxy]ethyl}piperidine | Drug Info |
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