Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(morpholinomethyl)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-methyl-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| Ftase --- FPTase | pentapotassium ({[(3E,7E)-4,8,12-trimethyl-1-phosphonatotrideca-3,7,11-trien-1-yl]phosphinato}methyl)phosphonate | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-[(1E)-4-piperidin-1-ylbut-1-en-1-yl]nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-methyl]-benzoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-1H-indol-3-yl-acryloylamino)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-4-(1,4-Diazepan-1-yl)but-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-3,4-dimethoxy-benzenesulfonamide | Drug Info |
| H3 --- SERT | 1-isopropyl-4-(4-(3-((methylamino)methyl)-4-(4-(methylthio)phenoxy)phenyl)but-3-ynyl)piperazin-2-one | Drug Info |
| EGFR3 --- HER2 | 4-(3-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(pyrimidin-2-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-(chlorodifluoromethoxy)phenyl)benzamide | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | CHEMBL271705 | Drug Info |
| PI3K gamma --- PI3K delta | 6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-2-pyridin-3-yl-thieno[3,2-d]pyrimidine | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-bromophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | N,N-diethyl-3-(8-(4-methoxyphenyl)-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 4-(3-chloro-4-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(piperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-3-yl)ethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (1S,10R,11R,13S,14R)-4-[1-butylsulfanyl-meth-(Z)-ylidene]-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-tert-butylphenyl)benzamide | Drug Info |
| HD6 --- HDAC2 | N-hydroxy-4-(((R)-3,6-dioxo-2-((thiophen-2-yl)methyl)piperazin-1-yl)methyl)benzamide | Drug Info |
| EGFR3 --- HER2 | SID124350107 | Drug Info |
| PKCA --- NPKC delta | 18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| HDAC1 --- HD6 | (S)-3-biphenyl-4-yl-2-(8-hydroxycarbamoyl-octanoylamino)-propionic acid methyl ester | Drug Info |
| EGFR3 --- HER2 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-[morpholin-4-yliminomethyl]-pyrimidine-4,6-diamine | Drug Info |
| PKCA --- NPKC delta | N-cyclohexyl-4-(1-(piperazin-1-yl)-2,6-naphthyridin-3-yl)pyridin-2-amine | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | Octanedioic Acid-{3-[1-(3-Fluoro-4-methoxyphenyl)-1H-[1,2,3]-triazol-4-yl]phenyl}amide-Hydroxyamide | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Benzyloxy-phenylamino)-quinazolin-6-yl]-acrylamide | Drug Info |
| PKCA --- NPKC delta | 3-(2-Chloropyridin-4-yl)-1-piperazin-1-yl[2,6]naphthyridine | Drug Info |
| VEGFR2 --- VEGFR1 | (2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indazol-3-yl)methanone | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-2-(3-guanidinopropyl)-11-isobutyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | 4-Diisopropylamino-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-chloro-6-(3-chlorophenylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-4-(3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-1H-pyridin-2-one | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-isopropyl-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyhexanamide | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E,4E)-Hexadienoyl]-7-(5-methyl-2-{2-[(1E)-3-methylbuten-1-yl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoqunoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| HDAC1 --- HD6 | 2-(4-Acetylamino-phenyl)-2-oxoethyl Ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | (R,E)-N4-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((2-(methoxymethyl)pyrrolidin-1-ylimino)methyl)pyrimidine-4,6-diamine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(7-chloro-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-3-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide | Drug Info |
| EGFR3 --- VEGFR1 | 1-(4-Fluoro-phenyl)-3-(1,3,8a,9-tetraaza-fluoren-4-yl)-urea | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-ethyl-2-(furan-2-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
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