Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-3-yl)-amide | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(4-(4-(trifluoromethyl)phenoxy)piperidin-1-ylsulfonyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-N-(1-acetylpiperidin-4-yl)-4-(2,5-difluorophenyl)-N-methyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-(3-(2-oxoazepan-3-yl)phenoxy)benzonitrile | Drug Info |
| MMP2 --- MMP13 | 2-(4-Benzyl-piperidine-1-sulfonyl)-N-hydroxy-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(7-(trifluoromethyl)-9H-carbazol-3-yl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{(S)-2-[(S)-2-Amino-3-(3H-imidazol-4-yl)-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-1-(2-carboxyethylamino)-3-cyclohexyl-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (2R)-2-Amino-3-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(3-quinolin-2-ylmethyl-3H-imidazol-4-yl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | 2-[4-(3'-ethoxy-2-methyl-biphenyl-4-yl)-piperidine-1-sulfonyl]-N-hydroxy-2-methyl-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-amino-2-cyclopropyl-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)ethanone | Drug Info |
| Ftase --- FPTase | Pseudopeptide derivative | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(3'-trifluoromethyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-(2-aminoethyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | SID146411 | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4-(tetrahydro-furan-2-yl)-phenyl]-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-dimethyl-N'-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo[1,2-a]quinolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| MMP-2 --- MMP-3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylpropylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-{1-(2,5-difluoro-phenyl)-4-[3-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-propyl]-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl}-ethanone | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[2-(1-methyl-1H-imidazol-4-yl)-ethyl]-amide} | Drug Info |
| MMP2 --- MMP9 | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-(2'-methoxy-biphenyl-4-ylmethyl)-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-3-carboxy-1,2,3,4-tetrahydro-beta-carboline-3-(N-(2-hydroxyethyl))formamide | Drug Info |
| Ftase --- FPTase | 3-Biphenyl-4-ylethynyl-4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-methyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbaldehyde | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4'-chloro-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)biphenyl-4-sulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-2,2-dimethylpropan-1-one | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(aminomethyl)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| MMP2 --- MMP9 | 2-(4-(2,4,6-Trioxo-5-(4-phenoxyphenyl)hexanhydropyrimidin-5-yl)-1,4-diazepane-1-carbonyl)benzylbenzoate | Drug Info |
| Lck --- VEGFR | 1-(2-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamido)-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazine-1-carboxylic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-phenoxyphenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| Src --- VEGFR | Benzofuran-7-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid aminomethyl-amide | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-(2-thiomorpholinoethyl)benzenesulfonamide | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-N-methyl-N-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-5-amine | Drug Info |
| Ftase --- FPTase | 1-(((2R,3R)-3-(2,4-dichlorobenzyloxy)-5-fluoro-2,3-dihydrobenzo[b]thiophen-2-yl)methyl)-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzoylamino-benzenesulfonylamino)-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| VEGFR2 --- Beta PDGFR | N4-(4-Chlorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-2-{4-[2-(4-Cyclohexyl-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-3-phenyl-propionic acid | Drug Info |
| VEGFR2 --- CDK1 | 2-(3-methoxy-4-(pyrrolidin-1-ylmethyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | Biphenyl-2-yl-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| MMP2 --- MMP9 | 2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-morpholinoethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Hydroxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | epicatechin-(4beta-8)-epicatechin-(4beta-6)-epicatechin | Drug Info |
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