Multi-target agents

Target Pair Drug Name
PPAR gamma --- PPAR delta 5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-carboxy-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester Drug Info
Erbeta --- ER {4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-phenyl}-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-methanone Drug Info
JNK1 --- JNK3 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethoxy)quinolin-1(2H)-yl)acetamide Drug Info
PR --- mRNA of AR N-(1-Difluoromethoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide Drug Info
Erbeta --- ER (2S,3R)-2-{4-[2-(8-Aza-bicyclo[3.2.1]oct-8-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol Drug Info
JNK3 --- MAPK 6-((S)-3-Isobutyl-piperazin-1-yl)-3-naphthalen-1-yl-4-pyridin-4-yl-pyridazine Drug Info
PR --- mRNA of AR (5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methanol Drug Info
Erbeta --- ER [6-Hydroxy-2-(1-oxy-pyridin-4-yl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone Drug Info
MEP --- Cathepsin B (S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(pyridin-4-yl)biphenyl-4-yl)ethylamino)pentanamide Drug Info
PR --- mRNA of AR N-(3-(4-cyano-3-fluorophenyl)-1-isopropyl-1H-indol-6-yl)methanesulfonamide Drug Info
Erbeta --- ER CHEMBL1195267 Drug Info
MEP --- Cathepsin B Cyclohexanecarboxylic acid [(S)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide Drug Info
PR --- mRNA of AR Acetic acid 5-bromo-4-methoxy-2-(5,5,7-trimethyl-spiro[2.5]oct-7-en-4-ylmethyl)-phenyl ester Drug Info
Erbeta --- ER 7-bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol Drug Info
MEP --- Cathepsin B (S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide Drug Info
PR --- mRNA of AR 6'-trifluoromethylspiro[cyclohexane-1,2'-(1',2',3',4',8',9'-hexahydropyrido[3,2-g]quinoline)]-8'-one Drug Info
Erbeta --- ER 4-((1R,2R,5R)-5-Hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-2-methoxy-phenol Drug Info
MEP --- Cathepsin B (S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide Drug Info
PR --- mRNA of AR racemic-5-chloro-6-(1H-indol-3-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline Drug Info
Erbeta --- ER N,N-Diisobutyl-(6-styryl-pyrimidin-2,4-yl)-diamine Drug Info
Met --- VEGFR N-(4-(2-(4-(dimethylcarbamoyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide Drug Info
PR --- mRNA of AR N-(3-(4-cyano-3-methoxyphenyl)-1-isopropyl-1H-indol-6-yl)methanesulfonamide Drug Info
Erbeta --- ER 12-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-7,12-dihydro-benzo[a]anthracene-3,9-diol Drug Info
Met --- VEGFR (R)-N1-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamide Drug Info
PR --- mRNA of AR 6-(3-chloro-4-fluorophenyl)-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one Drug Info
Erbeta --- ER (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(4-isopropylpiperazin-1-yl)phenyl)methanone Drug Info
Met --- VEGFR N-(3-fluoro-4-(2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide Drug Info
Renin --- Cathepsin D (1S,5S)-7-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide Drug Info
Erbeta --- ER (2-Biphenyl-4-yl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone Drug Info
MMP1 --- MMP3 1,3-Bis-(4-methoxy-benzenesulfonyl)-[1,3]diazepane-2-carboxylic acid hydroxyamide Drug Info
S5AR --- SRD5A2 Bexlosteride Drug Info
Erbeta --- ER 3-(4-(3-butyl-2-(4-methoxyphenyl)naphthalen-1-yloxy)phenyl)acrylic acid Drug Info
MMP1 --- MMP3 N-hydroxy-2-[[diphenylphosphinyl]-(2-phenylethyl)-amino]-acetamide Drug Info
S5AR --- SRD5A2 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid phenyl ester Drug Info
Erbeta --- ER 2-(4-hydroxyphenyl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)benzo[b]thiophen-6-ol Drug Info
MMP1 --- MMP3 {(S)-3-[(R)-2-((R)-1-Hydroxycarbamoyl-ethyl)-decanoylamino]-2-oxo-azepan-1-yl}-acetic acid methyl ester Drug Info
S5AR --- SRD5A2 17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,6-dione Drug Info
Erbeta --- ER 1-Chloro-6-(2-fluoro-4-hydroxy-phenyl)-naphthalen-2-ol Drug Info
MMP1 --- MMP9 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-4-methylpentanamide Drug Info
S5AR --- SRD5A2 (8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-4-fluoro-10,13-dimethyl-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid Drug Info
Erbeta --- ER 1-{2-[4-(4-Phenyl-2,3-dihydro-benzo[b]oxepin-5-yl)-phenoxy]-ethyl}-pyrrolidine Drug Info
MMP13 --- MMP1 (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-[1-(benzenesulfonyl)-piperidin-4-yl]-acetic Acid Drug Info
S5AR --- SRD5A2 (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid p-tolylamide Drug Info
Erbeta --- ER 5-[4-(3-Hydroxypropoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthal ene-2,8-diol Drug Info
MMP13 --- MMP1 (S)-4-(4-(6-aminohex-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide Drug Info
S5AR --- SRD5A2 N,N-Diethyl-2-(1,4a,6a-trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinolin-7-yl)-acetamide Drug Info
Erbeta --- ER 3-Chloro-4-((1R,2R,5R)-5-hydroxymethyl-1,8-dimethyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol Drug Info
MMP13 --- MMP1 4-[4-(Naphthalen-1-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide Drug Info
S5AR --- SRD5A2 8-Methoxy-4a-methyl-3,4,4a,9-tetrahydro-phenanthrene-2-carboxylic acid Drug Info
Erbeta --- ER SID17510892 Drug Info

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