Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[3-(2-oxo-pyrrolidin-1-yl)-propyl]-amide} | Drug Info |
| NPKCdelta --- NPKCtheta | N-{1-[(3E)-4-{5-Cyano-4-[(4-methyl-1H-indol-5-yl)amino]-pyridin-3-yl}but-3-en-1-yl]piperidin-4-yl}acetamide | Drug Info |
| VEGFR2 --- VEGFR1 | [4-(2-Phenyl-imidazol-1-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine | Drug Info |
| Ftase --- FPTase | 6-[(3-Bromo-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| CAII --- CAI | 3-Hydroxy-3-phenyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| NPKCdelta --- NPKCtheta | N-{1-[(3E)-4-{5-Cyano-4-[(4-methyl-1H-indol-5-yl)amino]-pyridin-3-yl}but-3-en-1-yl]piperidin-4-yl}methanesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-bis(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | N-methyl(2-(3-methyl-4-(methylthio)phenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-3-(2-(4-methoxypiperidin-1-yl)ethoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(2-((dimethylamino)methyl)-5-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | (2-(2-chloro-4-fluorophenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-3-(2-(piperazin-1-yl)ethoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-(1-methyl-1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-(4-(methylthio)phenoxy)-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(4-benzyloxy-3,5-dichloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-methoxypyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)phenyl)-1Hpyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-(2,5-dichlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-pyrido[3,2-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1213085 | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Bromo-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HD6 --- HDAC2 | 4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | Drug Info |
| EGFR3 --- HER2 | 4-(4-fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3S,4R)-3-(4-hydroxy-benzoylamino)-oxepan-4-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 3,5-Dichloro-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{4-[(1-pyridine-3-yl-methanoyl)-amino]-phenyl}-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyanoquinolin-6-yl)-4-morpholinobut-2-enamide | Drug Info |
| PKCA --- NPKC delta | (R)-2-{2,6-Dihydroxy-4-[(3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-ylcarbamoyl]-benzoyl}-3-hydroxy-benzoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | GW627512B | Drug Info |
| HDAC1 --- HD6 | (S)-2-(phenylmethylsulfonamido)-N-(4-phenylthiazol-2-yl)-6-(sulfamoylamino)hexanamide | Drug Info |
| EGFR3 --- HER2 | 4-amino-6-(3-chloro-4-fluorophenylamino)pyrimidine-5-carbaldehyde O-methyl oxime | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (S)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | N-Ethyl S-2-(4-methoxy-phenyl)-2-oxoethyl thiocarbamate | Drug Info |
| EGFR3 --- HER2 | 6,7-dimethoxy-4-(3-nitrophenylamino)quinoline-3-carbonitrile | Drug Info |
| PPAR delta --- LXRalpha | 2-(3-chloro-4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)phenyl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | 3-(3-(4,5-dimethyl-1-phenethyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | (4-Benzyloxy-3-chloro-phenyl)-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| PPAR gamma --- LXRalpha | 3-{3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}-N-propylbenzamide | Drug Info |
| HDAC1 --- HD6 | N-Hydroxy-8-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)octanamide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propynamide | Drug Info |
| PPAR gamma --- PPAR delta | {4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethoxy]-phenoxy}-acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-pyridin-3-ylmethyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- PKCA | K00570a | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(5-hydroxypent-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | (2S,5R)-benzyl 4-(5-((2-aminophenyl)carbamoyl)pyridin-2-yl)-2,5-dimethylpiperazine-1-carboxylate | Drug Info |
| Erbeta --- ER | 3-(4-Fluoro-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
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