Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 4-Chloro-2-(4-hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(quinolin-4-ylmethoxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-4-iodo-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 7-ethyl-4-fluoro-3,8-dihydroxy-6H-benzo[c]chromen-6-one | Drug Info |
| MMP13 --- MMP14 | 5-amino-3-(2-ethoxyethyl)-3-[4-(4-methanesulfonylphenoxy)phenoxy]piperidine-2,4,6-trione | Drug Info |
| FGFR --- Src | 3-(2,6-Dichloro-phenyl)-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Erbeta --- ER | 7-(3-Fluoro-4-hydroxy-phenyl)-3-hydroxy-4-methyl-naphthalene-1-carbonitrile | Drug Info |
| MMP13 --- MMP9 | 2-(4-but-2-ynyloxyphenylsulfanyl)octanoic acid hydroxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | methyl 4-((3-aminopropyl)(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)carbamoyl)benzoate | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-isopropyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP2 --- MMP1 | N-[1-(Biphenyl-4-yloxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-N-hydroxy-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 9-(Trifluoromethyl)-4,7-dihydro-1H-pyrido[2,3-c]carbazol-3(2H)-one | Drug Info |
| Erbeta --- Mcl1 | SID14742218 | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(pyridin-2-yl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(4-trifluoromethylphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| FGFR --- PDGFR | 3-Phenyl-3H-benzoimidazol-5-ol | Drug Info |
| MMP2 --- MMP13 | (R)-2-(6-ethyl-N-isopentylnaphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1,5-di-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxy]-3-oxapentane | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(naphthalen-2-yloxy)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | CHEMBL1940308 | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-methyl-N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-butyl-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-N-(4-fluorobenzyl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2,3,4,11-tetrahydro-1H-benzo[a]carbazole | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-3-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-3-methyl-2-(4'-(3-methyl-4-(methylamino)benzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)butanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-propan-1-one | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(N-isopropoxy-4'-isopropylbiphenyl-4-ylsulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3-fluoro-4-methoxyphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | Drug Info |
| Ftase --- FPTase | 2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-phenyl-propionyl)-piperazin-2-yl]-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP14 | 3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(2-(dimethylamino)ethyl)-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-2-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyl]-6-(4-propyl-phenyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-5,7-dichloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 1-{4-[3-((2R,3R)-5-tert-Butyl-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-[1,2,4]thiadiazol-5-yl]-piperazin-1-yl}-ethanone | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2-chloro-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-((3R,3aR)-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl)-ethanone | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-nitrobenzyl)quinoline-2-carboxamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methoxy-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-2-(piperidin-4-yl)ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-3-phenyl-propionylamino)-4-hydroxy-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-propyl-phenyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-benzyl-3-(4-hydroxyphenyl)-6-(pyrrolidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphthalen-1-yl-benzoylamino}-4-methyl-pentanoic acid | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(4-morpholino-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butan-2-yl)formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 2-{4-[4-(4-cyano-phenyl)-piperazin-1-yl]-benzenesulfonyl}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.