Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| mTOR --- AKT | 1-{(2R,3R)-3-[6-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonyl)pyrazin-2-ylamino]-2-phenylpyrrolidin-1-yl}ethanone | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-6-methylphenyl)-1-(6-(4-(morpholinomethyl)pyridin-2-ylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| Ftase --- FPTase | N-Cyclopentyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(3-morpholinopropyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-chlorobenzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbothioyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 3-(9-((1-benzylpiperidin-4-yl)methyl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- EGFR3 | 4-(3-bromophenoxy)-6,7-dimethoxyquinazoline | Drug Info |
| Ftase --- FPTase | N-(3-chloro-phenyl)-5-cyano-2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-{4-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]phenyl}-urea | Drug Info |
| VEGFR2 --- FGFR1 | N-(4-Benzyloxy-butyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-3-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- MCSF | GW856804X | Drug Info |
| Ftase --- FPTase | 6-[(4'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | N-[2-(Dimethylamino)ethyl]-4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}aminobenzamide | Drug Info |
| VEGFR2 --- TEK | 7-amino-19-methyl-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-(2-cyano-ethyl)-N-cyclopropyl-acetamide | Drug Info |
| NET --- SERT | 3N-{7-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarboxamido]heptyl}-4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxamide | Drug Info |
| VEGFR2 --- TEK | 2-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenoxy]-benzoic acid | Drug Info |
| Ftase --- FPTase | 4-{5-[(2-Oxo-3-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| NET --- SERT | 4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid {5-[3-(4-chloro-phenyl)-acryloylamino]-pentyl}-amide | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(5-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)-2-pyridyloxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | [1-(3-Benzyl-3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)furan-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(4-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3',5'-difluoro-biphenyl-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)thiophen-3-yl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methoxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-((1H-indol-5-yl)(methyl)amino)-5-(3,4-dimethoxyphenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | methyl (6-(4-(2-(2-fluoro-5-(trifluoromethyl)phenylamino)-2-oxoethyl)phenoxy)-1H-benzoimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | (S)-2-((3Z,6E)-(2S,5S,8R)-8-Amino-2-benzyl-5-isopropyl-9-mercapto-nona-3,6-dienoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((4-(dimethylamino)piperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(4-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cycloheptylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| CAII --- CAI | 6-Hydroxy-benzothiazole-2-sulfonic acid [2-(N-methyl-guanidino)-acetyl]-amide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(piperidin-1-ylmethyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(2-fluoro-4-methylphenyl)benzamide | Drug Info |
| H3 --- SERT | (6R,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-3-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | [3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(4-((4-hydroxypiperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(quinolin-4-ylmethyl)-2-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
| H3 --- SERT | (5-(4-(4-cyclopropylpiperazin-1-yl)but-1-ynyl)-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (1S,10R,11R,13S,14R)-4-diethylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 3-((4-(6-Methylpyridin-2-yl)-5-(quinolin-6-yl)-1H-imidazol-2-yl)methyl)benzamide | Drug Info |
| H3 --- SERT | 1-(4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-(3-cyanoacetamidophenoxy)pyrimidine | Drug Info |
| PI3K gamma --- PI3K delta | Phosphoric acid (R)-2-imidazol-1-yl-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester | Drug Info |
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