Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-sulfonic acid dimethylamide | Drug Info |
| MMP2 --- MMP9 | 6-mercapto-pyridine-2-carboxylic acid 3-methyl-benzyl ester | Drug Info |
| VEGFR2 --- CDK1 | 4-phenyl-2-(4-(pyrrolidin-1-ylmethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-4-Carbamoyl-2-[((S)-2-{(S)-2-[2-(3H-imidazol-4-yl)-ethylamino]-3,3-dimethyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-butyric acid | Drug Info |
| MMP2 --- MMP9 | SID56314762 | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-hydroxyethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2-carboxylic acid | Drug Info |
| MMP2 --- MMP9 | (R)-2-(Biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(3-bromophenyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2-(4-fluoro-benzyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | [3-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid ethyl ester | Drug Info |
| VEGFR2 --- Cmet | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| Ftase --- FPTase | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carbonyl)-amino]-acetic acid ethyl ester | Drug Info |
| MMP3 --- MMP8 | [7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (3-methyl-isoxazol-5-yl)-amide | Drug Info |
| MMP3 --- MMP8 | [6-tert-Butoxycarbonylamino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-1-yl)propyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP9 --- MMP3 | 3-(Formyl-hydroxy-amino)-2-isobutyl-hexanoic acid [4-{[amino-(pyridine-2-sulfonylimino)-methyl]-amino}-1-(thiazol-2-ylcarbamoyl)-butyl]-amide | Drug Info |
| VEGFR2 --- CSrc | (3-Chloro-benzofuran-7-yl)-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-cyclohexylmethyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- AKT | N-(2-Chloro-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
| VEGFR2 --- CSrc | N-(5-chloro-1,3-benzodioxol-4-yl)-5-morpholin-4-yl-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-phenyl-piperidine-1-carboxamidine | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea | Drug Info |
| VEGFR2 --- CSrc | (2-Chloro-5-methoxy-phenyl)-[6-methoxy-7-(4-methyl-piperazin-1-ylmethoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-methyl-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- EGFR3 | benzyl-(7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-dibenzo[a,d]cyclohepten-1-yl)-amine | Drug Info |
| Ftase --- FPTase | 4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid (3,4-dichloro-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide | Drug Info |
| mTOR --- PI3K gamma | (S)-N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-morpholino-6-((tetrahydrofuran-3-yl)oxy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
| VEGFR2 --- FGFR1 | N-(3-Benzyloxy-propyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| Ftase --- FPTase | 4-((2R,3R)-6-Chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-5-methyl-3-phenyl-isoxazole | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-(dimethylamino)ethoxy)phenyl)urea | Drug Info |
| VEGFR2 --- HER2 | 6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen-2-ylmethyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-phenylurea | Drug Info |
| VEGFR2 --- TEK | (R)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(dimethylamino)pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-2-phenylethan-1-one | Drug Info |
| NET --- SERT | 8-Dimethylcarbamoylmethyl-3-(4-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- TEK | 4-fluorophenyl N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}carbamate | Drug Info |
| Ftase --- FPTase | 15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| NET --- SERT | SID533835 | Drug Info |
| VEGFR2 --- TEK | 1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | [Hydroxy-(5,9,13-trimethyl-tetradeca-4,8,12-trienyl)-phosphinoylmethyl]-phosphonate | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(6-((4-hydroxypiperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-(trifluoromethyl)phenyl)aminothiocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-methyl-piperidin-3-yl ester | Drug Info |
| NPKCdelta --- NPKCtheta | CHEMBL2140607 | Drug Info |
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