Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | (2,4-Dichloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| Erbeta --- ER | 7-butyl-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-{4-[4-(1H-pyrazol-4-yl)-phenoxy]-phenoxy}-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | (4-tert-Butoxy-3,5-dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| Erbeta --- ER | 3-(4-(3-butyl-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
| MMP13 --- MMP3 | 3-{1-[(Methoxy-phenyl-methyl)-carbamoyl]-2,2-dimethyl-propylcarbamoyl}-6-(2-methyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| FGFR --- Src | N-{6-(2,6-Dichloro-phenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-3,3-dimethyl-butyramide | Drug Info |
| Erbeta --- ER | (S)-1-(4-(2-(pyrrolidin-1-yl)propoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-N-hydroxy-3-methyl-2-{methyl-[4'-(thiazol-2-ylmethoxy)-biphenyl-4-sulfonyl]-amino}-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(trifluoromethyl)-9H-carbazole | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-hydroxyphenyl)-2-(4-((S)-2-(pyrrolidin-1-yl)butoxy)phenyl)-2,3-dihydrobenzo[b][1,4]oxathiin-6-ol | Drug Info |
| MMP2 --- MMP1 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-ethoxy-biphenyl-4-yloxymethyl)-ethyl]-N-hydroxy-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxamide | Drug Info |
| Erbeta --- Mcl1 | SID7975783 | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-{1-isobutyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-pyrrolidin-3-yl}-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-phenyl-1H-pyrrol-3-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-o-tolylpiperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-Chloro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | CHEMBL2365012 | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(2,5-dichlorothiophen-3-ylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-oxo-1-propyl-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP13 | 2-(Biphenyl-4-sulfonylamino)-6-pyrrolidin-1-yl-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-fluoro-2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-6-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[7-((R)-2-Amino-3-mercapto-propionylamino)-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Hydroxymethyl-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3''-methoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP13 | (3S)-4-{[4-(but-2-ynylamino)phenyl]sulfonyl}-Nhydroxy-2,2-dimethylthio-morpholine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylsulfonyl)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-ethyl-piperazin-1-yl]-(2,3-dimethyl-phenyl)-methanone | Drug Info |
| MMP2 --- MMP14 | 3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(2-methylbenzoyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-(3,3-difluoropyrrolidin-1-yl)propyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| MMP2 --- MMP3 | (R)-N4-hydroxy-N1-((S)-1-((R)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-((1E,3E)-hepta-1,3-dienyl)-benzonitrile | Drug Info |
| MMP2 --- MMP3 | 2-(4-biphenyl-4-yl-3,6-dihydro-2H-pyridine-1-sulfonyl)-N-hydroxy-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2,5-Difluoro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 2-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(2',6'-dimethyl-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)furan-2-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(tert-butylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(3-chloro-4-fluorophenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-[(3,5-dimethyl-isoxazol-4-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP9 | piperidin-1-ylcarbonylphosphonic acid | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.