Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(piperidin-1-ylsulfonyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 9-isobutyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-nitro-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1,4-dimethyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-6-benzylthieno[2,3-d]pyrimidin-5-yl)phenyl)-3-m-tolylurea | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)benzofuran-2-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | N-{1-[(3E)-4-{5-Cyano-4-[(4-methyl-1H-indol-5-yl)amino]-pyridin-3-yl}but-3-en-1-yl]piperidin-4-yl}ethanesulfonamide | Drug Info |
| VEGFR2 --- TEK | rac-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| GSK --- VEGFR | Cyclopropanecarboxylic acid (6-phenyl-furo[2,3-d]pyrimidin-4-yl)-amide | Drug Info |
| EGFR3 --- HER2 | (E)-2-Cyano-3-[4-hydroxy-3-methoxy-5-(pyridin-2-ylsulfanylmethyl)-phenyl]-acrylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N-phenylacrylamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-phenoxyphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | (5-(4-(4-fluoropiperidin-1-yl)but-1-ynyl)-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid (4-{3-chloro-4-[(1,6-dihydro-pyridin-3-ylmethyl)-amino]-phenylamino}-3-cyano-7-methoxy-quinolin-6-yl)-amide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-benzyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(4-chloro-2-methyl-benzoyl)-benzenesulfonamide | Drug Info |
| H3 --- SERT | (6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-2-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[4-(benzyl-methyl-amino)-3-chloro-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)isothiazole-3-carboxamide | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-(3-(4-Methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-methoxypyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | [3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol | Drug Info |
| H3 --- SERT | (R)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methylmorpholino)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylic acid | Drug Info |
| PI3K gamma --- PI3K delta | 4-(Difluoromethoxy)-2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-methoxy-benzenesulfonamide | Drug Info |
| HDAC --- VEGFR | N2-(2-aminophenyl)-N5-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2,5-dicarboxamide | Drug Info |
| EGFR3 --- HER2 | 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-ethyl oxime | Drug Info |
| PKCA --- NPKC delta | 17,23-dimethyl-20-oxa-4,14,17,23,26-pentaazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | N-(benzo[d][1,3]dioxol-5-yl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 6-((5S,8S,11S)-11-isobutyl-2,2-dimethyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | TCMDC-135511 | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid(3R,4R)-2-(4-hydroxy-benzoylamino)-cyclopentylmethyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | (R)-3-(3-(4-benzyl-1-(1-ethylpiperidin-3-yl)-5-methyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-7-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PKCA --- NPKC delta | 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-quinolin-3-yl-1H-indol-3-yl)-pyrrole-2,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | 3-(3-(1-(2-(dimethylamino)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | 4-(3-bromophenylamino)-6,7-bis(2-methoxyethoxy)quinoline-3-carbonitrile | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(p-tolyloxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | 3-(3-(2,4-dimethyl-1-phenethyl-1H-imidazol-5-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | 2-(3-Phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(1-(3-(6-benzoyl-1-propylnaphthalen-2-yloxy)propyl)-1H-indol-6-yloxy)-2-methylpropanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 3-methyl-1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{4-[(quinoline-3-carbonyl)-amino]-phenyl}-ethyl trithiocarbonate | Drug Info |
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