Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | (R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Thiophene-6-methyl-N-(4-methoxyphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-ethyl-9H-carbazole | Drug Info |
| Ftase --- FPTase | 2-(4-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-(thiophen-2-yl)acetyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(1-(2,5-difluorophenyl)-4-phenyl-4-(3-(pyrrolidin-1-yl)propyl)-4,5-dihydro-1H-pyrazol-3-yl)ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | N-benzyl-N-(1-hydroxy-2-thioxo-1,2-dihydropyridin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-Hydroxyphenyl)-2-(alpha-aminopropionyl)-6-chloro-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| Ftase --- FPTase | (2-Bromo-phenyl)-[1-(3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-succinamide | Drug Info |
| Src --- VEGFR | CHEMBL383593 | Drug Info |
| Ftase --- FPTase | [(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid benzyl ester | Drug Info |
| MMP2 --- MMP9 | 11-(3',5'-Dichloro-biphenyl-4-ylmethyl)-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide] | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | 5-((2-cyanobenzyloxy)(1-methyl-1H-imidazol-5-yl)methyl)-2'-methylbiphenyl-2-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxoazepan-3-yl)benzenesulfonamide | Drug Info |
| VEGFR2 --- AuroraA | 6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-oxo-acetamide | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(isobutylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- CD135 | N-(3-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)phenyl)-4-morpholino-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | 3-hydroxy-1-((5-(4-methoxyphenoxy)thiophen-2-ylsulfonyl)methyl)pyridin-2(1H)-one | Drug Info |
| VEGFR2 --- CDK1 | N,N-diethyl-2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-7-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| MMP2 --- MMP9 | 5-(4-(Cyclopropylmethyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-acetyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorophenoxy)phenyl)methan-15-ylsulfonamido)-N,2-dihydroxypropanamide | Drug Info |
| VEGFR2 --- Ckit | 1-methyl-3-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-1-m-tolylurea | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-3-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP3 --- MMP8 | N-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-(trifluoromethyl)phenyl)malonamide | Drug Info |
| Ftase --- FPTase | 17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Chloro-biphenyl-4-sulfonyl)-7-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | SID103905591 | Drug Info |
| MMP3 --- MMP8 | 5-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-4-methoxy-thiophene-3-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-3-Methyl-2-{2-[1-(4-nitro-benzyl)-1H-imidazol-4-yl]-acetylamino}-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]oxazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | Lithium; (S)-4-methylsulfanyl-2-({2'-methyl-5-[5-(4-trifluoromethyl-phenyl)-furan-2-ylmethoxymethyl]-biphenyl-2-carbonyl}-amino)-butyrate | Drug Info |
| mTOR --- AKT | N-(5-(Benzo[d]thiazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
| VEGFR2 --- CSrc | 2-((4-((2-(dimethylamino)ethyl)oxy)-phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(1,4'-bipiperidine-1'-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-4-(trifluoromethyl)benzamide | Drug Info |
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