Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | SID14725275 | Drug Info |
| MMP13 --- MMP1 | (S)-4-(4-(4-aminobut-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| VEGFR2 --- TEK | 9-(2-hydroxyethyl)-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Erbeta --- ER | 2,3-Bis-(4-hydroxy-phenyl)-acrylonitrile | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-(4-m-tolyloxy-phenoxy)-piperidine-2,4,6-trione | Drug Info |
| VEGFR2 --- TEK | N-(3-(3-(dimethylamino)propyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 1-{2-[4-((3S,4R)-7-Methoxy-3-phenyl-isothiochroman-4-yl)-phenoxy]-ethyl}-pyrrolidine | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-2-{[4-(4-tert-butyl-phenoxy)-benzenesulfonyl]-methyl-amino}-N-hydroxy-3-methyl-benzamide | Drug Info |
| VEGFR2 --- TEK | CHEMBL526925 | Drug Info |
| Erbeta --- ER | 2-(3,5-Difluoro-4-hydroxy-phenyl)-4-ethynyl-quinolin-6-ol | Drug Info |
| MMP2 --- HER2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| VEGFR2 --- TEK | 4-methyl-N-phenyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-benzamide | Drug Info |
| Erbeta --- ER | SID3716652 | Drug Info |
| MMP2 --- MMP1 | (R)-N*1*-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-N*4*-pyridin-2-yl-succinamide | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)phenyl)-1H-tetrazole-5-carboxamide | Drug Info |
| Erbeta --- mRNA of AR | (3S,4R,8R,9S,10S,13S,14S,17S)-4-allyl-13-methyl-10-vinyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(2-methoxyphenyl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-N-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-((5-((3-oxo-4-phenylpiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP13 | 6-(4-Methanesulfonyl-piperazin-1-yl)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-hex-4-ynoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | {3-Methyl-5-[4-(2-phenyl-imidazol-1-yl)-pyrimidin-2-ylamino]-phenyl}-methanol | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propane-1-thiol | Drug Info |
| MMP2 --- MMP13 | 5-(biphenyl-4-yl)-3-hydroxypentanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-Bromo-2-fluoro-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| Ftase --- FPTase | [4-(1H-Imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-benzo[e][1,4]diazepin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-amino-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-4,5-dimethyl-6-(pyridin-4-ylmethyl)pyridazin-3-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-cyano-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-4-methylpentanamide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(4-tert-butylphenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid phenyl ester | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-1-(isopropylsulfonyl)-4-[({4-[(1-methylbut-2-yn-1-yl)oxy]phenyl}sulfonyl)-methyl]piperidine-4-carboxamide | Drug Info |
| VEGFR2 --- VEGFR1 | (5-Ethanesulfonyl-2-methoxy-phenyl)-[5-(3-pyridin-4-yl-phenyl)-oxazol-2-yl]-amine | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-2-naphthamide | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-4-(4-methoxy-phenyl)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-butyl]-phosphinic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-N-(4-methyl-3-(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | [7-Bromo-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP3 | 4-((2-methylquinolin-4-yl)methoxy)-N-((5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzenesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | GW572401X | Drug Info |
| Ftase --- FPTase | 6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-methyl-amino}-methyl)-3''-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(benzhydrylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(3-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[(3-Cyclohexylmethyl-3H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4-(1H-indol-2-yl)-phenyl]-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-({(R)-2-[(S)-2-((R)-3-Mercapto-2-methyl-propionylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP8 | pentan-3-ylcarbamoylphosphonic acid | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,3-dimethyl-but-1-ynyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-fluoro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| Ftase --- FPTase | (S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| MMP2 --- MMP9 | 2-amino-N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)acetamide | Drug Info |
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