Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(cyclohexylidenemethyl)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | SID103905193 | Drug Info |
| Erbeta --- ER | 5,7-dihydroxy-3-(2-fluoro-4-hydroxyphenyl)-4(3H)-quinazolinone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-{2-[1-(2-Biphenyl-4-yl-ethyl)-3-cyclohexyl-ureido]-ethyl}-phenylsulfanyl)-2-methyl-propionic acid | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-{4-[(6R,7S)-2-(octahydro-isoindol-2-yl)-ethoxy]-phenyl}-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | rac-2-(4-Methoxy-3-((4-phenethoxybenzamido)methyl)benzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-(4-hydroxy-phenyl)-pyrrolo[2,1,5-cd]indolizin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarbamoyl)benzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-{6-methyl[3-(4,4,5,5,5-pentafluoropentylsulfanyl)propyl]aminohexyl}-(E)-1-butenyl]phenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(2-(2-(3,5-dimethoxyphenyl)-5-methyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)-2-methoxypropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(4-Hydroxymethyl-piperidin-1-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(pyridin-4-ylmethyl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(2,4-Dichloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| JNK1 --- JNK3 | N-(4-(1H-1,2,3-Triazol-1-yl)phenyl)-4-(3-morpholinophenyl)-pyrimidin-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-ethyl-2-(pyridin-2-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| Erbeta --- ER | 3-(4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenylthio)-2-methylpropanoic acid | Drug Info |
| Erbeta --- ER | 2-Bromo-N-[2-((R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-ethyl]-acetamide | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-propoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| PR --- mRNA of AR | 7-Ethyl-8,8-dimethyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | 3-Bromo-2-(4-hydroxy-phenyl)-5-methoxy-inden-1-one | Drug Info |
| MEP --- Cathepsin B | 1-((3,5-dichlorophenyl)(p-tolyl)methylene)thiosemicarbazide | Drug Info |
| PR --- mRNA of AR | 5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol | Drug Info |
| Erbeta --- ER | 2-Phenyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | Z-Phe-Ala-H | Drug Info |
| PR --- mRNA of AR | WAY-255348 | Drug Info |
| Erbeta --- ER | 3-(3-Bromo-4-hydroxy-phenyl)-2,2-dimethyl-2H-benzo[1,4]oxazine-5,7-diol | Drug Info |
| MEP --- Cathepsin B | (R)-N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(3-aminopyrrolidin-1-yl)thiazol-4-yl)benzamide | Drug Info |
| PR --- mRNA of AR | (Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-chromeno[3,4-f]quinolin-9-ol | Drug Info |
| Erbeta --- ER | Poricotriol A[(20R)-3,4-seco-24-methyllanosta-4(28),7,9-(11),24(241)-tetraene-3,16alpha,21-triol] | Drug Info |
| MEP --- Cathepsin B | (S)-N-(3-(3-(1H-pyrazol-4-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)benzamide | Drug Info |
| PR --- mRNA of AR | (4R,5S)-5-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| Erbeta --- ER | (E)-7,8-Bis-(4-hydroxy-phenyl)-dec-7-enoic acid methyl-[3-(4,4,5,5,5-pentafluoro-pentylsulfanyl)-propyl]-amide | Drug Info |
| MEP --- Cathepsin B | 4'-[Methyl-(1-methyl-pyrrolidin-3-yl)-amino]-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PR --- mRNA of AR | 7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Erbeta --- ER | 8-(3-methylbutyl)naringenin | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(morpholine-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| PR --- mRNA of AR | Methyl 2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(2-chloro-4-fluorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-6-(3-(piperidin-1-yl)propoxy)-1H-indol-3-yl)acetamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carbothioamide | Drug Info |
| Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-4-(3-methoxy-propyl)-2,15-dioxo-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(3,4-Difluoro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Renin --- Cathepsin D | (S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-isobutylcarbamoyl-hexyl)-2-(3-methyl-butyrylamino)-succinamic acid | Drug Info |
| Erbeta --- ER | 4-{5-(4-hydroxy-phenyl)-4-propyl-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-furan-2-yl}-phenol | Drug Info |
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