Multi-target agents
Target Pair | Drug Name | |
---|---|---|
MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-(2-morpholino-2-oxoethyl)benzenesulfonamide | Drug Info |
PR --- mRNA of AR | 5-Bromo-4-methoxy-2-((1R,2S)-2-methyl-6-methylene-cyclohexylmethyl)-phenol | Drug Info |
Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-phenoxybenzonitrile | Drug Info |
MMP2 --- MMP9 | (4S)-4-amino-5-oxo-5-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenylamino)pentanoic acid | Drug Info |
PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-phenylpropan-1-one | Drug Info |
Ftase --- FPTase | 4-fluoro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
MMP2 --- MMP9 | (S)-N-hydroxy-2-(pyridin-2-ylmethylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
PR --- mRNA of AR | (R)-3-(4-Hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)-propanamide | Drug Info |
Ftase --- FPTase | [(S)-4-((S)-2-Amino-2-mercapto-ethyl)-3-butyl-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
MMP2 --- MMP9 | (S)-benzyl 2-((1-(hydroxyamino)-1-oxo-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propan-2-yl)(isopropyl)amino)ethylcarbamate | Drug Info |
PR --- mRNA of AR | 8-Ethyl-8-methyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-3-methyl-pentanoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
MMP2 --- MMP9 | Succinic acid mono-[4-hydroxycarbamoyl-2-(4-phenoxy-benzoylamino)-pentyl] ester | Drug Info |
PR --- mRNA of AR | N-(3-Dibenzylamino-2-methyl-phenyl)-methanesulfonamide | Drug Info |
Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(3-bromobenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
MMP2 --- MMP9 | (S)-3-{[4-(4-chloro-phenoxy)-phenyl]-isobutyryl-amino}-2,N-dihydroxy-propionamide | Drug Info |
PR --- mRNA of AR | 3-[(4-methoxyphenyl)phenylmethyl]indole | Drug Info |
Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carbothioic acid methylamide | Drug Info |
MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-N-methylbenzenesulfonamide | Drug Info |
PR --- mRNA of AR | 8-Chloro-6-[1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one | Drug Info |
Ftase --- FPTase | (S)-2-(2-{[(S)-2-(2-Benzyloxy-acetylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
MMP2 --- MMP9 | (S)-3-((R)-Isobutyl)-4-oxo-6-((R)-phenylmethyl)-2-phenylsulfanylmethyl-heptanedioic acid 1-hydroxyamide 7-methylamide | Drug Info |
Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-2,15-dioxo-4-phenyl-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
Ftase --- FPTase | (4E,8E)-2-((S)-3-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-propyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | Drug Info |
MMP3 --- MMP8 | 7-Amino-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-acetylamino-phenyl ester | Drug Info |
Ftase --- FPTase | 8-Chloro-11-(1-phenylmethanesulfonyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
MMP3 --- MMP8 | (R)-2-(4-Phenoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid | Drug Info |
S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid benzhydryl-amide | Drug Info |
Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(methylthiomethyl)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
MMP9 --- MMP3 | (2R,3S)-N*1*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2-(7-fluoro-naphthalen-2-ylmethyl)-3,N*4*-dihydroxy-succinamide | Drug Info |
S5AR --- SRD5A2 | 4-[2-(6-{[Bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid | Drug Info |
Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one | Drug Info |
mTOR --- AKT | (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl){6-[(2R,3R)-2-(4-fluorophenyl)tetrahydrofuran-3-ylamino]-pyrazin-2-yl}methanone | Drug Info |
S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-bromo-phenyl)-amide | Drug Info |
Ftase --- FPTase | (S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
mTOR --- DNPK1 | 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one | Drug Info |
S5AR --- SRD5A2 | 3-(1-Methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1Hpyrrole-2,5-dione | Drug Info |
Ftase --- FPTase | 23-oxo-4-(2-phenyl-1-ethynyl)-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
mTOR --- PI3K gamma | (3-(9-(1-(2,4-difluorophenyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol | Drug Info |
S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-chloro-phenyl)-amide | Drug Info |
Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-4'-ethoxybiphenyl-3-carbonitrile | Drug Info |
mTOR --- PI3K gamma | (3-(3-(1-benzylpiperidin-4-yl)-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)methanol | Drug Info |
S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-oxo-acetic acid | Drug Info |
Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(2-chloro-6-fluoro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridazin-4-yl)urea | Drug Info |
S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-ethoxy-phenyl ester | Drug Info |
Ftase --- FPTase | (S)-2-{[5-((Z)-1-tert-Butoxycarbonyl-2-pyridin-3-yl-vinyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
mTOR --- PI3K gamma | 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea | Drug Info |
ABL --- Src | 4-(2,4-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbaldehyde | Drug Info |
Pagination
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