Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| H3 --- SERT | 2-(4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)phenol | Drug Info |
| EGFR3 --- HER2 | 3-(3-cyano-6,7-dimethoxyquinolin-4-ylamino)benzamide | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (3aS,5R,5bR,6S,11bR)-5-acetoxy-6-methoxymethyl-3a,5b-dimethyl-8,11-dioxo-3a,4,5,5b,11,11b-hexahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-3-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)isothiazole-3-carboxamide | Drug Info |
| H3 --- SERT | (2-(3-chlorophenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {3-cyano-4-[3,5-dichloro-4-(3-fluoro-benzyloxy)-phenylamino]-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PI3K gamma --- PI3K delta | TG100-115 | Drug Info |
| VEGFR2 --- VEGFR1 | [3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol | Drug Info |
| H3 --- SERT | (S)-2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-morpholinoethyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-2-methyl-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-methoxy-benzenesulfonamide | Drug Info |
| H3 --- SERT | 7-(3-(4,4-difluoropiperidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(benzo[d][1,3]dioxol-5-yl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HD6 --- HDAC4 | ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate | Drug Info |
| EGFR3 --- HER2 | 4-Thiomorpholin-4-yl-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-[2-hydroxy-6-(1H-tetrazol-5-yl)-benzoyl]-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | ethyl 2-(5-(2-(4-methoxyphenylamino)-2-oxoethyl)thiophen-2-yl)-2-oxoethyl trithiocarbonoate | Drug Info |
| EGFR3 --- HER2 | DDD01067522 | Drug Info |
| PKCA --- NPKC delta | (E)-{2-(hydroxymethyl)-4-[4-methyl-3-(methylethyl)pentylidene]-5-oxo-2,3-dihydrofur-2-yl}methyl 4-hydroxybenzoate | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(2-(4-(2-(dimethylamino)ethoxy)phenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | (4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine | Drug Info |
| PKCA --- NPKC delta | dihexan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(4-((perfluorobenzyloxyimino)methyl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-phenethyloxy-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-biphenyloxypropoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 3-methyl-1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | 4-[(2-Hydroxy-ethyl)-methyl-amino]-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E)-3-(Furan-2-yl)acryloyl]-7-(2-{5-methyl-2-[(1E)-5-methylhexen-1-yl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-2-(5-acetamidopentyl)-11-isobutyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methanesulfonate | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(7-chloro-8-methyl-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-2-oxo-octanoic acid methylamide | Drug Info |
| EGFR3 --- VEGFR1 | 2-(Methyl-{4-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzyl}-amino)-ethanol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-bis(4-methoxyphenyl)allyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 2-Oxo-nonanedioic acid 1-methylamide 9-quinolin-3-ylamide | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (1'S*,5'R*)-6-(5-Heptyl-2-Iodo-4-oxocyclopent-2-enyloxy)hexanoic Acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(2-(4-fluorophenyl)oxazol-5-yl)-N-hydroxyheptanamide | Drug Info |
| Erbeta --- ER | 1-(2-{4-[8-Fluoro-4-(4-fluorophenyl)-2,3-dihydro-benzo[b]-oxepin-5-yl]-phenoxy}-ethyl)-pyrrolidine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)phenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 9a-(4-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
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