Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | N-Isopropyl-2-[2-(2-methoxy-phenyl)-1H-indol-3-yl]-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-methyl-2-(N-(pyridin-4-ylmethyl)naphthalene-2-sulfonamido)butanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-amino-N-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-fluoro-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP14 | (S)-2-{4'-[(Benzofuran-2-ylmethyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4-[3-(4-acetyl-piperazin-1-yl)-propyl]-1-(2-fluoro-5-methyl-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 1-[3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| MMP2 --- MMP3 | (R)-2-((S)-4-(4-isopropylphenyl)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxobutan-2-ylamino)propanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | methyl 2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylate | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(1,3-dimethyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)-N4-hydroxy-2-nonylsuccinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Phenyl-6-methyl-N-(4-trifluoromethylphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalen-1-ylmethyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | [(S)-2-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-(4-phenylacetylamino-butyl)-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)methanesulfonamide | Drug Info |
| Ftase --- FPTase | 1-(3-Benzo[1,3]dioxol-5-ylmethyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrole-3-carboxylic acid (2-methoxy-ethyl)-methyl-amide | Drug Info |
| MMP2 --- MMP3 | (6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Benzoyl-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorobenzyloxy)phenyl)methan-8-ylsulfonamido)-N,2-dihydroxypropanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-methylbenzamide hydrochloride | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Methoxy-phenylethynyl)-benzenesulfonylamino]-3-phenyl-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(3-hydroxyphenyl)-2-methyl-6-(pyrrolidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-(4-phenoxy-phenyl)-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-{4-[2-(4-methoxy-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-(piperidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| DHFR --- VEGFR | 5-[(R/S)-2-Cyclopropyl-2-(20-methoxyphenyl)ethyl]furo-[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-benzo[1,3]dioxol-4-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(3'-methoxy-biphenyl-4-sulfonylamino)-propionic acid | Drug Info |
| Src --- VEGFR | N-(3-chloro-6-methoxypyridin-2-yl)-5-isopropoxy-7-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 5-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-6-methyl-4-oxo-heptanoic acid | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-5-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-3-yl)-amide | Drug Info |
| MMP2 --- MMP9 | 2-{4-[4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-benzenesulfonyl}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| VEGFR2 --- AuroraA | 6-methoxy-2-(4-(2-(4-methylpyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10-methyl-10,11-dihydro-5H-4,10-diaza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-2-{(S)-3-Dimethylamino-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-N-hydroxy-propionamide | Drug Info |
| VEGFR2 --- CD135 | (Z)-{2,4-Dimethyl-5-[2-oxo-6-(3-phenylureido)-1,2-dihydroindol-3-ylidene-methyl]-1H-pyrrol-3-yl}acetic acid | Drug Info |
| Ftase --- FPTase | 6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1H-quinolin-2-one | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indazol-3-yl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-hexanoic acid | Drug Info |
| MMP2 --- MMP9 | 1-hydroxy-3-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)azepan-2-one | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid isopropylamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(1-phenyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)ethyl)formamide | Drug Info |
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