Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(Trifluoromethyl)-3,9-dihydropyrrolo[2,3-b]carbazol-2(1H)-one | Drug Info |
| Ftase --- FPTase | Cyclic peptide analogue | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-cyclohexylacetyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-4-(2,5-difluorophenyl)-2-(3-(ethylamino)propyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(2-Phenyl-1H-indol-3-yl)-N,N-bis-pyridin-3-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | (R)-5-(4-chlorophenyl)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholinoethyl)thiophene-2-sulfonamide | Drug Info |
| DHFR --- VEGFR | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3,5-diethoxybenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Src --- VEGFR | [6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-(4-methoxy-phenyl)-amine | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butan-2-yl)formamide | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | 2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-methyl-4-(4-(trifluoromethoxy)phenoxy)benzenesulfonamide | Drug Info |
| VEGFR2 --- AuroraA | N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | Drug Info |
| Ftase --- FPTase | 4-chloro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP2 --- MMP9 | 1-hydroxy-3-(4-(4-methoxyphenoxy)phenylsulfonyl)azepan-2-one | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-3-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 4-(5-cyano-2-(4-(2-hydroxyethyl)phenylamino)pyrimidin-4-yl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | N-Furan-3-ylmethyl-N-isopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenylazo-benzenesulfonylamino)-propionic acid | Drug Info |
| VEGFR2 --- CDK4 | 4-(2-butylpyrazolo[1,5-b]pyridazin-3-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | (2-Benzylamino-phenyl)-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-butyric acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(4-((methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylmethyl-amide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| MMP3 --- MMP8 | [(R)-6-Amino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid phenylamide | Drug Info |
| MMP9 --- MMP3 | (R)-2-((S)-2-Hydroxy-3-mercapto-propyl)-nonanoic acid [(S)-1-(2-ethylamino-4-methyl-pentanoylaminocarbonyl)-3-methyl-butyl]-amide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3,5-dichlorobenzamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(3,4-Dichloro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3-(methoxy)-4-((2-(4-methyl-1-piperazinyl)ethyl)-oxy)phenyl)amino)pyrimido[5',4':5,6]-pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 6-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| mTOR --- DNPK1 | 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one | Drug Info |
| VEGFR2 --- CSrc | Benzofuran-7-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 2-(N-Methylindol-3-ylmethylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3,4,5-trimethoxyphenyl)amino)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-(4-morpholin-4-ylphenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(pyridin-2-ylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide | Drug Info |
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