Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3-hydroxy-phenylethynyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylquinoline-2-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2,2-dimethylpropan-1-one | Drug Info |
| Ftase --- FPTase | (4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a]quinazolin-7-yl)(1-methyl-1H-imidazol-5-yl)methanamine | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-4-phenylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-acetyl-4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(Cyclohexyl-hydroxy-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (R)-2-(N-benzylnaphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-4-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-3-Hydroxy-2-{(S)-2-[(S)-2-(3-mercapto-propionylamino)-3-methyl-butyrylamino]-4-methyl-pentanoylamino}-propionic acid | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(pyridin-4-yl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-(3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-5-yl)butyl)-1H-imidazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2,4-Dichloro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(pyridin-4-yl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 8-(Trifluoromethyl)-3,4-dihydro-1H-pyrido[3,2-b]carbazol-2(6H)-one | Drug Info |
| Ftase --- FPTase | Lonafarnib | Drug Info |
| MMP2 --- MMP3 | (R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-octanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[7-(Trifluoromethyl)-9H-carbazol-2-yl]urea | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid pyrazin-2-ylamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methanesulfonyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829408 | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-dimethylcarbamoyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-Biphenyl-3-yl-2-butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxyphenyl)-8-methoxy-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,7-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP3 | 3-[(S)-3-Cyclohexyl-2-((S)-5-phenyl-2-phosphonomethyl-pentanoylamino)-propionylamino]-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-((3R,3aR)-2-acetyl-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-3-yl)-propyl]-4-methyl-[1,4]diazepan-5-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(1-oxy-pyridin-3-ylmethyl)-piperidine-1-carboxamidine | Drug Info |
| MMP-2 --- MMP-3 | (R)-3-(((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-4-methyl-N-(1-(4-oxo-3-(pyridin-4-ylmethyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-Chloro-3-(4-chloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-piperazin-1-yl)-pyrimidine-2,4,6-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID99356130 | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-phenylsulfanyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfonylamino)-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829416 | Drug Info |
| Ftase --- FPTase | (Z)-Octadec-9-enoic acid {2-[3-(2,3-dimethyl-phenylsulfamoyl)-phenylcarbamoyl]-ethyl}-amide | Drug Info |
| MMP2 --- MMP9 | (R)-N-hydroxy-2-methoxy-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(thiazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-thiazol-5-yl-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-2-([1,1'-biphenyl]-4-ylsulfonamido)-3-phenylpropanoic acid | Drug Info |
| Lck --- VEGFR | N-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | (4-Amino-cyclohexyl)-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-methanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-cyclopentylpropanoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Src --- VEGFR | CHEMBL426161 | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(quinolin-5-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzoylamino-benzenesulfonylamino)-3-methyl-butyric acid | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-5-(3-(pyrrolidin-1-yl)propoxy)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid (4-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Methyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)-pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
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