Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-2,3-dihydro-1H-indole-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| NET --- SERT | (2R,3S)-3-(2-Hydroxy-4-iodo-benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- TEK | rac-9-(2-(diethylamino)ethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(3-(3-hydroxypyrrolidin-1-yl)-3-oxoprop-1-enyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | (E/Z)-4-(2-(1-benzyl-4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 1-(3H-Imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid diphenylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(3,4-dimethoxyphenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(2-(quinolin-3-yl)ethynyl)-N-(3-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-(5-Bromo-furan-2-ylmethoxymethyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(2,2-Dimethylpropanoyl)piperazin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(thiophen-2-yl)urea | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-4-ylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpiperazin-1-ylsulfonyl)methyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | Biphenyl-3-sulfonic acid 2,4-dichloro-benzoylamide | Drug Info |
| FTase --- GTase | 1-methyl-1H-imidazole-4-sulfonic acid {2-[biphenyl-4-yl-(3-methyl-3H-imidazol-4-ylmethyl)amino]ethyl}-(2-methylbenzyl)-amide | Drug Info |
| CDK1 --- CDK2 | 2-[4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-phenyl]-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinomethyl)furan-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(pyridin-4-ylmethyl)-2-(1-(quinolin-2-yl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
| H3 --- SERT | 4-(4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)benzonitrile | Drug Info |
| EGFR3 --- HER2 | CHEMBL194337 | Drug Info |
| PI3K gamma --- PI3K delta | (S)-10-Hydroxy-3a,6-dimethyl-3-oxo-1,3,3a,10b-tetrahydro-2H-9-oxa-dicyclopenta[a,g]naphthalene-7-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-yl)quinolin-3-amine | Drug Info |
| H3 --- SERT | (6S,10bR)-9-(3-morpholinopropoxy)-6-(thiazol-5-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(thiazol-4-ylmethoxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957851 | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(4-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-4-ylmethyl)aniline | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenyl-3-(3-(3-(piperidin-1-yl)propoxy)phenoxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-(2-fluorophenyl)acrylate | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | (6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(pyridin-3-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidine-5-carbaldehyde O-2-morpholinoethyl oxime | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-thiomorpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | (5-Ethanesulfonyl-2-methoxy-phenyl)-[5-(4-methoxy-phenyl)-oxazol-2-yl]-amine | Drug Info |
| HD6 --- HDAC4 | 2,2,2-trifluoro-1-(5-(3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | FALNIDAMOL | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-methoxycarbonyl-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 2-((3S,6S,9S,13S)-9-(3-guanidinopropyl)-6-(6-(hydroxyamino)-6-oxohexyl)-13-(4-hydroxybenzyl)-2,5,8,11-tetraoxo-1,4,7,10-tetraazacyclotridecan-3-yl)acetic acid | Drug Info |
| EGFR3 --- HER2 | 4-(4-Fluoro-3-trifluoromethyl-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile hydrochloride | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-(2,2,2-trifluoro-acetyl)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | GW580509X | Drug Info |
| HDAC1 --- HD6 | (S)-N8-hydroxy-2-(1H-indole-2-carboxamido)-N1-(quinolin-8-yl)octanediamide | Drug Info |
| EGFR3 --- HER2 | 4-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxybutanamide | Drug Info |
| PKCA --- NPKC delta | 7,10-diisopropyl-8,10,13-trimethyl-13-vinyl-7,8,10,11,12,13-hexahydro-1H-benzo[g][1,4]diazonino[7,6,5-cd]indole-4,6(3H,5H)-dione | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(4-chloro-3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-[5-((S)-1-phenyl-ethylcarbamoyl)-thiophen-2-yl]-ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | CHEMBL255170 | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(2,3-dimethylphenoxy)propoxy)benzyl)hexanoic acid | Drug Info |
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