Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HDAC1 --- HD6 | 3-(3-(4-benzyl-5-methyl-1-(2-morpholinoethyl)-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-azido-N-(2-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethoxy)ethyl)-2,3,5,6-tetrafluorobenzamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyanoquinolin-6-yl)-4-(2-(methoxymethyl)pyrrolidin-1-yl)but-2-ynamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(3-methoxyphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-3-(4-furan-3-yl-phenyl)-2-(7-hydroxycarbamoyl-heptanoylamino)-propionic acid methyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | 4-(3-acetylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-chloro-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-2-(8-hydroxycarbamoyl-octanoylamino)-3-(4-naphthalen-2-yl-phenyl)-propionic acid methyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(benzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid 2-(piperazin-1-yl)ethyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((3-(4-isobutylphenyl)-1-methyl-1H-pyrazole-5-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 1H-Indole-7-carboxylic acid (5-hydroxycarbamoyl-pentyl)-amide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(quinolin-4-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)isothiazole-3-carboxamide | Drug Info |
| ER --- PR | 17alpha-Ethynyl-17-hydroxy-18-ethyl-4-estren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(1-((5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)-1H-indol-5-yl)-2-propoxypropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 2-oxo-nonanedioic acid 9-biphenyl-3-ylamide 1-methylamide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(benzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| Erbeta --- ER | 6-(3,4-difluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(2-(benzo[d]oxazol-2-yl(3-phenoxypropyl)amino)ethyl)phenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Bromo-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| Erbeta --- ER | methyl 2,3-bis(4-hydroxyphenyl)propanoate | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(4-(2-chloro-4-(4-fluorophenoxy)phenoxy)butoxy)phenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 3-[4-(Biphenyl-4-yloxy)-butylsulfanyl]-1,1,1-trifluoro-propan-2-one | Drug Info |
| Erbeta --- ER | 4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3H-inden-1-yl]-benzamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-cycloheptyl-2-propylphenoxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC4 | (S)-benzyl 1-(cyclopentylamino)-7-mercapto-1-oxoheptan-2-ylcarbamate | Drug Info |
| Erbeta --- ER | 1-[4-(4-Cyclopentyl-piperazin-1-yl)-phenyl]-2-(3-hydroxy-phenyl)-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-((2-fluoro-4-(trifluoromethyl)benzyl)carbamoyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| HDAC2 --- HDAC4 | N-hydroxy-2,3-diphenylpropanamide | Drug Info |
| Erbeta --- ER | 9a-butyl-4-(furan-2-yl)-7-hydroxy-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-[4-(3-biphenyl-4-yl-but-2enyloxy)-phenyl]-2-ethoxy-propionic acid | Drug Info |
| HER2 --- MMP-2 | (6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino[1,2-a]indol-2(1H)-ylcarbonyl)-5-azaspiro[2.5]octane-7-carboxamide | Drug Info |
| Erbeta --- ER | 7,9-dibromo-3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(2-(2-cyclohexyl-5-methyloxazol-4-yl)ethoxy)phenyl)-2-methyl-2-phenoxypropanoic acid | Drug Info |
| JAK2 --- STK1 | 5-(1-(3-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole | Drug Info |
| Erbeta --- ER | 4-{Cyclohexylidene-[4-(2-diisopropylamino-ethoxy)-phenyl]-methyl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 4-Isocyanato-benzoic acid 2-((2,4-bis-trifluoromethyl-benzyl)-{3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-propyl}-amino)-ethyl ester | Drug Info |
| JNK1 --- JNK3 | N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)nicotinamide | Drug Info |
| Erbeta --- ER | CHEMBL1192929 | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-((benzo[d]oxazol-2-yl(3-(2,4-dimethylphenoxy)propyl)amino)methyl)phenoxy)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-p-tolyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-(4-butoxy-3-((2-fluoro-4-(trifluoromethyl)benzamido)methyl)benzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-isobutoxypicolinamide | Drug Info |
| Erbeta --- ER | 4-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-4-yl)phenoxy]ethyl}morpholine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((3-(3-fluoro-4-(trifluoromethoxy)phenyl)-1,2,4-thiadiazol-5-yl)methylsulfanyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-(3-hydroxyprop-1-ynyl)picolinamide | Drug Info |
| Erbeta --- ER | (2R,3S)-5-Chloro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
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