Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | 6-(4-chlorobenzyl)-7-(2-cyclopentylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | N-{1-[2-(4-Methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-4-propyl-benzamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclohexyl-1-((S)-4-(methylsulfonyl)-1-(4-(trifluoromethoxy)phenylamino)butan-2-ylamino)-1-oxopropan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | 4-[2-(1-Methyl-piperidin-4-yl)-ethoxy]-6-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-ethyl 3-(4-cyclohexyl-2-(3-methoxybenzamido)butanamido)-4-(5-fluoroindolin-1-yl)butanoate | Drug Info |
| Cathepsin K --- MEP | {(S)-1-[(S)-1-Benzyl-2-(4-morpholin-4-yl-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 4-Isopropyl-N-{1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-benzamide | Drug Info |
| CCKBR --- CCKAR | 4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-butyric acid | Drug Info |
| CCKBR --- CCKAR | (S)-3-[(S)-2-[(S)-2-(Adamantan-2-yloxycarbonylamino)-3-1H-indol-3-yl-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | CHEMBL1172429 | Drug Info |
| CCKBR --- CCKAR | (R)-5-(4-Benzoyl-piperidin-1-yl)-5-oxo-4-(3-m-tolyl-ureido)-pentanoic acid | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(3-bromo-4-fluorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | (R)Quinoline-3-carboxylic acid [1-dipentylcarbamoyl-2-(2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-pyridin-3-yl-acryloylamino)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indolyl)ethylcarboxamido]-5-formamidometa-methyl phenylaminopentylcarboxamido}-3-(1-carbamoyl-2-phenylethylcarbamoyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-sulfo-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid.NH4OH; hydrate | Drug Info |
| CCKBR --- CCKAR | [2-(1H-Indol-3-yl)-1-methyl-1-(3-phenyl-propylcarbamoyl)-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-methoxy-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CD135 --- Ckit | 1-(4-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-ylamino)phenyl)-4-morpholinobutan-1-ol | Drug Info |
| CD221 --- STK1 | 2-(2-(2-fluoro-4-(1-propyl-1,4,5,6-tetrahydropyridin-3-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- CDK2 | 6-(cyclohexylmethoxy)-N-phenyl-9H-purin-2-amine | Drug Info |
| CDK1 --- CDK2 | 4-(2-(4-chloro-5-methyl-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- GSK3 | SID529761 | Drug Info |
| CDK1 --- GSK3 | SID516208 | Drug Info |
| CDK1 --- GSK3 | SID527705 | Drug Info |
| CDK2 --- AKT | (S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)-3-phenylpropane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide | Drug Info |
| CDK2 --- AuroraA | 8-({3-[(Dimethylamino)methyl]phenyl}amino)-N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | GW305178X | Drug Info |
| CDK2 --- CDK1 | 4-(4-amino-6-(benzyloxy)-5-nitrosopyrimidin-2-ylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2-(4-methyl-5-nitro-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | SID537006 | Drug Info |
| CDK2 --- CDK1 | 8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-2-(4-hydroxy-3-trifluoromethyl-phenyl)-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | 4-(2-(4-chloro-5-methyl-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 6-Iodo-4-{[(4-hydroxy-5-methoxy-pyridin-2-ylmethyl)-amino]-methylene}-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | 4-[2-(4-Fluoro-3-methyl-phenylamino)-pyrimidin-4-yl]-3,5-dimethyl-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | N-(4-(benzylsulfonyl)phenyl)-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL430507 | Drug Info |
| CDK2 --- Cyclin E | 2-[6-(4-Methoxy-benzylamino)-9-methyl-9H-purin-2-ylamino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-N6-(4-(furan-2-yl)benzyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | 4'-((2-(trans-4-aminocyclohexylamino)-9-isopropyl-9H-purin-6-ylamino)methyl)biphenyl-3-carboxylic acid | Drug Info |
| CDK2 --- Cyclin E | 2-{(2-Hydroxy-ethyl)-[6-(4-methoxy-benzylamino)-9-((Z)-octadec-9-enyl)-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | 1-(4-Methoxy-phenyl)-2H-2,3,5-triaza-cyclopenta[a]inden-8-one | Drug Info |
| CDK2 --- Cyclin E | 2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propane-1,2-diol | Drug Info |
| CDK2 --- Cyclin E | 3-{6-[(Biphenyl-4-ylmethyl)-amino]-9-isopropyl-9H-purin-2-ylamino}-propane-1,2-diol | Drug Info |
| CDK2 --- Cyclin E | 3-methyl-5-phenyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- GSK3 | (3-Methoxy-phenyl)-[4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CAII --- CAI | 2-(4-fluorophenyl)-N-(4-sulfamoylphenyl)acetamide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Dimethylamino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
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