Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR --- PDGFR | (E)-2-Cyano-3-(1H-indol-3-yl)acrylamide | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-(2-sulfamoyl-benzothiazol-6-yl)-benzamide | Drug Info |
| EGFR3 --- CSrc | 6-(3-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenylcyclopropylamino)quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(4-sulfamoyl-phenyl)-ethyl ester | Drug Info |
| EGFR3 --- HER2 | 2-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | {(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | 4-(1-(3-fluorobenzyl)indolin-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-methyl oxime | Drug Info |
| CAII --- CAI | 6-Hydroxy-benzothiazole-2-sulfonic acid (2-amino-acetyl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-((R)-1-phenyl-ethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-(2-sulfamoyl-phenyl)-benzamide | Drug Info |
| EGFR3 --- HER2 | 1-(5-Bromo-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylthiourea | Drug Info |
| CAII --- CAI | {2-[(2-Sulfamoyl-benzothiazol-6-yloxycarbonylmethyl)-amino]-ethylamino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyanoquinolin-6-yl)acrylamide | Drug Info |
| CAII --- CAI | 6-(2-Hydroxy-ethoxy)-benzothiazole-2-sulfonic acid [2-(N-methyl-guanidino)-acetyl]-amide | Drug Info |
| EGFR3 --- HER2 | (E)-3-[3-(2-Acetylamino-phenylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide | Drug Info |
| CAII --- CAI | 3-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-hydroxy-ethyl ester | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidin-5-yl)-1-(4-ethylpiperazin-1-yl)-2-fluoroprop-2-en-1-one | Drug Info |
| CAII --- CAI | 2-(4-Sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxypropanamide | Drug Info |
| CAII --- CAI | 3-[3-(4-Sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| CAII --- CAI | 6-(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 6,6,7,7,7-Pentafluoro-heptanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| CAII --- CAI | N-(aminosulfonyl)-2,3,4,5,6-pentafluorobenzenesulfonamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 4-sulfamoyl-benzyl ester | Drug Info |
| CAII --- CAI | (S)-2-(4-Chloro-3-sulfamoyl-benzoylamino)-3-(3H-imidazol-4-yl)-propionic acid | Drug Info |
| CAII --- CAI | 5-(Nonafluorobutane-1-sulfonylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CAII --- CAIX | 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-[alpha-(4-fluorophenyl)methylene]semicarbazide | Drug Info |
| CAII --- CAIX | 2-(benzyloxyamino)-N-hydroxyhexanamide | Drug Info |
| CAIX --- CAXII | 7-Hydroxy-4-propyl-2H-benzo-1-pyran-2-one | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-methanesulfonylamino-propionamide | Drug Info |
| CALM2 --- Cathepsin B | (S)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzylsulfanyl-2-methanesulfonylamino-propionamide | Drug Info |
| CALM2 --- Cathepsin B | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(4-methylpiperazin-1-yl)propyl)-2-oxopentanamide | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 5-Methyl-1-phenyl-1H-pyrazole-4-carboxylic acid {(S)-2-cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(4-methoxy-3,5-dimethylphenylamino)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | 6-[4-(4-Acetyl-piperazin-1-yl)-2-fluoro-phenoxymethyl]-7-(2-cyclohexyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclohexyl-1-oxo-1-((S)-1-(4-(trifluoromethoxy)phenylamino)propan-2-ylamino)propan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-3-(1-methylcyclopentyl)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | SID14739111 | Drug Info |
| Cathepsin K --- MEP | 2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-5-carboxylic acid (1-methyl-4-phenyl-piperidin-4-ylmethyl)-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclohexyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| CCKBR --- CCKAR | {[2-(Adamantan-2-yloxycarbonylamino)-2-methyl-3-phenyl-propionyl]-phenethyl-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | (R)-4-Chloro-N-[5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide | Drug Info |
| CCKBR --- CCKAR | 3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indolyl)ethylcarboxamido]-5-formamido-para-methyl phenylaminopentylcarboxamido}-3-(1-carbamoyl-2-phenylethylcarbamoyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | [2-(1H-Indol-3-yl)-1-methyl-1-(naphthalen-2-ylcarbamoyl)-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5S,7R)-5-(2-methoxy-phenyl)-2-oxo-7-phenyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | 2-{(3R,5R)-3-[3-(3-Benzenesulfonylaminocarbonyl-phenyl)-ureido]-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-N-tert-butyl-acetamide | Drug Info |
| CCKBR --- CCKAR | (5S,11S,14S,17S)-11-((1H-indol-3-yl)methyl)-17-((S)-1-amino-1-oxo-3-phenylpropan-2-ylcarbamoyl)-5-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-14-(2-(methylthio)ethyl)-6,9,12,15-tetraoxo-2-thia-7,10,13,16-tetraazanonadecan-19-oic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(3,4-dimethoxy-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
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