Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(2-morpholinoethylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | N-Methyl-4-[(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-(2-Dimethylamino-ethyl)-4-[(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonyl)-3-morpholinopropanamide | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(3-Hydroxy-4-propoxybenzyl)amino]methylene}-6-iodoisoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | N-(2-(diethylamino)ethyl)-3-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)benzamide | Drug Info |
| CDK2 --- CDK4 | 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol | Drug Info |
| CDK2 --- CDK4 | 1-Dimethylamino-3-{4-[4-(2-fluoro-phenylamino)-pyrimidin-2-ylamino]-phenoxy}-propan-2-ol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((2-phenylthiazol-4-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | (1-(6-(biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)cyclopentyl)methanol | Drug Info |
| CDK2 --- Cyclin E | N2-(3-aminopropyl)-N6-(biphenyl-4-ylmethyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | (5-(2-chlorophenyl)-7-nitro-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepin-3-yl)methanol | Drug Info |
| CDK2 --- Cyclin E | 4-(naphthalen-1-yldiazenyl)-1H-pyrazole-3,5-diamine | Drug Info |
| CDK2 --- Cyclin E | 5-(2-fluorophenyl)-3-methyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N2-((1R,2S)-2-aminocyclohexyl)-N6-(biphenyl-4-ylmethyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | [4-(6-Methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid (2-sulfamoyl-benzothiazol-6-yl)-amide | Drug Info |
| CDK4 --- Cyclin E | 1-[3-(5-Chloro-thiophen-3-yl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | (R)-4-((1R,5S,6S,8R,11S,12S,17S)-3,12-Dihydroxy-7-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid ((R)-5-chloro-2,4-disulfamoyl-phenyl)-amide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyrimidin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 2-Amino-N-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-acetamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(methylsulfonyl)ethyl)picolinamide | Drug Info |
| CAII --- CAI | 2-Amino-N-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-acetamide | Drug Info |
| COX2 --- 5LOX | 5-Methyl-5,6,7,8,9,10-hexahydro-cyclohepta[b]indol-2-ol | Drug Info |
| CAII --- CAI | 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| COX2 --- 5LOX | 2,6-Diisopropyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 4-[N'-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoyl)-hydrazino]-benzenesulfonamide | Drug Info |
| COX2 --- HRH1 | 11-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-Amino-N-(4-sulfamoyl-benzyl)-acetamide | Drug Info |
| CSrc --- CABL | 4-benzylidene-1-(4-iodophenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | N-Ethyl-N-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-4-nitrooxymethyl-benzamide | Drug Info |
| CSrc --- CABL | 9-(2-chlorostyryl)-N-(4-(dimethylphosphoryl)phenyl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 4-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-ylmethyl)-benzenesulfonamide | Drug Info |
| CSrc --- CABL | 4-(4-iodobenzylidene)-1-(4-iodophenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | 4-(((1-methyl-1H-pyrrol-2-yl)methyleneamino)methyl)benzenesulfonamide | Drug Info |
| CSrc --- CABL | 1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1Hpyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (R)-4-((2R,6S,7S,8S,10R,12S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethyl]-amide | Drug Info |
| CSrc --- CABL | rac-1-(2-chloro-2-(4-fluorophenyl)ethyl)-N-(3-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | N-(4-hydroxyphenyl)sulfamide | Drug Info |
| DHFR --- MMP-9 | methotrexate gamma-L-phenylalaninehydroxamic acid | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(4-sulfamoyl-phenyl)-ethyl ester | Drug Info |
| DHFR --- TYMS | SID536361 | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-benzamide | Drug Info |
| EGFR --- HER2 | But-2-enoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide | Drug Info |
| CAII --- CAI | 2-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Drug Info |
| EGFR --- Src | Acetic acid 2-(4-acetoxy-1-methyl-3-phenylcarbamoyl-1H-indol-2-yldisulfanyl)-1-methyl-3-phenylcarbamoyl-1H-indol-4-yl ester | Drug Info |
| CAII --- CAI | 4-Chloro-6-pentafluorobenzenesulfonylamino-benzene-1,3-disulfonic acid diamide | Drug Info |
| EGFR3 --- CSrc | methyl 4-{1-methyl-2-[1-methyl-3-(4-methyloxycarbonylbenzoyl)-1H-2-indolyldisulfanyl]-1H-3-indolylcarbonyl}benzoate | Drug Info |
| CAII --- CAI | 6-(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
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