Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | N-((S)-3-cyclopentyl-1-oxo-1-((S)-1-(4-(trifluoromethoxy)phenylamino)propan-2-ylamino)propan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | (1-phenethylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 6-(4-chlorobenzyl)-7-(3,3-dimethylbutyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-(1,3,4-thiadiazol-2-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)benzamide | Drug Info |
| Cathepsin K --- MEP | Benzoic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-4-oxo-azetidin-2-yl ester | Drug Info |
| CCKBR --- CCKAR | N-Carboxymethyl-N-[2-(2,4-dichloro-phenyl)-ethyl]-2-(1H-indol-3-ylmethyl)-2-methyl-malonamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(1H-indole-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-thioureido)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(naphthalene-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | (R)-1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide: 0.1C4H10O | Drug Info |
| CCKBR --- CCKAR | 3-{6-[3-(3-Acetyl-phenyl)-ureido]-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (+/-)-2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chloro-N-(2-(4-chlorophenyl)propyl)benzamide | Drug Info |
| CCKBR --- CCKAR | {[(S)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-phenethyl-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-nitro-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | {[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-propionyl]-phenethyl-amino}-acetic acid | Drug Info |
| CD135 --- Ckit | N3-(4-morpholinophenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine | Drug Info |
| CD221 --- JNK1 | 2-fluoro-6-(2-(5-methoxy-1-(2-morpholinoacetyl)indolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(3-(piperidin-1-yl)propyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-dimethyl-benzamide | Drug Info |
| CDK1 --- CDK4 | 2-(2-Bromo-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-chromen-4-one | Drug Info |
| CDK1 --- GSK3 | 9-Bromo-2-iodo-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK1 --- GSK3 | SID530149 | Drug Info |
| CDK1 --- VEGFR | 4-(4-(2-aminopropan-2-yl)phenyl)-N-(3-bromophenyl)-5-chloropyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (R)-N-((3,4-dichlorophenyl)(1-methylazetidin-3-yl)methyl)isoquinoline-6-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(4-Chloro-2-fluorophenylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- AuroraA | N,1,4,4-Tetramethyl-8-[(3-morpholin-4-ylphenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid dimethylamide | Drug Info |
| CDK2 --- CDK1 | Xylocydine | Drug Info |
| CDK2 --- CDK1 | (6-Cyclohexylmethoxy-9H-purin-2-yl)-isopropyl-amine | Drug Info |
| CDK2 --- CDK1 | K00054 | Drug Info |
| CDK2 --- CDK1 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N-methyl-benzamide | Drug Info |
| CDK2 --- CDK1 | 8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-2-(4-hydroxy-phenyl)-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | CHEMBL509406 | Drug Info |
| CDK2 --- CDK4 | 4-{[(6-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- CDK4 | CHEMBL515854 | Drug Info |
| CDK2 --- CDK4 | 8-Cyclohexyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- CDK4 | TCMDC-138687 | Drug Info |
| CDK2 --- Cyclin E | 2-{(2-Hydroxy-ethyl)-[6-(4-methoxy-benzylamino)-9-(2-methyl-butyl)-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | (E)-2-(5-((2-acetamidothiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)-N'-benzylideneacetohydrazide | Drug Info |
| CDK2 --- Cyclin E | 2-{(2-Hydroxy-ethyl)-[9-isopropyl-6-(quinolin-3-ylamino)-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | 3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-[(R)-4-hydroxy-3-(2-hydroxy-ethylamino)-but-1-ynyl]-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-[6-(4-chloro-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | N-(3-Cyclohexyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- GSK3 | 4-[5-(4-Amino-cyclohexylamino)-3-bromo-pyrazolo[1,5-a]pyrimidin-7-ylamino]-N,N-dimethyl-benzenesulfonamide | Drug Info |
| CAII --- CAI | 1-[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,4,6-trimethyl-pyridinium; perchlorate | Drug Info |
| CDK4 --- Cyclin E | N-[3-(5-methoxythien-2-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-2,2-dimethylhydrazinecarboxamide | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9R,10S,11S,14S,17R)-3,7,12-Trihydroxy-10-(R)-methyl-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(2-hydroxyethylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | (S)-4-Methylsulfanyl-2-(4-sulfamoyl-benzoylamino)-butyric acid | Drug Info |
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