Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CALM2 --- Cathepsin B | [(1S,2S)-1-((S)-1-Benzyl-2-oxo-2-phenethylcarbamoyl-ethylcarbamoyl)-2-isopropyl-cyclopropyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,3-dimethylbutan-2-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 3-Chloro-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | 5-(3-(4,5-dichloro-1H-imidazol-1-yl)prop-1-ynyl)-4-(neopentylamino)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(4-methoxyphenylamino)propan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-(4,4-dimethylcyclohexyl)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-{(S)-2-(2-Chloro-phenyl)-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | benzyl (2S,3S)-1-(cyanomethylamino)-3-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((S)-1-(4-methoxyphenylamino)propan-2-ylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(3-hydroxy-phenyl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydarte | Drug Info |
| CCKBR --- CCKAR | (S)-2-(4-bromo-2-(quinoxaline-5-sulfonamido)benzamido)-3-(3-bromo-4-fluorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-bromo-N-phenethylbenzamide | Drug Info |
| CCKBR --- CCKAR | (R)-5-(4-Benzoyl-piperidin-1-yl)-5-oxo-4-(3-m-tolyl-ureido)-pentanoic acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(5-hydroxy-1H-indole-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid.AcOH | Drug Info |
| CCKBR --- CCKAR | (-)-2-(S)-{2-[(1H-Indole-2-carbonyl)-amino]-benzoylamino}-4-phenyl-butyric Acid | Drug Info |
| CCKBR --- CCKAR | 3-Acetylamino-N-[1-(1-{2-[1-{1-[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-carboxy-ethylcarbamoyl]-pentylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-pyrrolidine-1-carbonyl}-pentylcarbamoyl)-2-(4-sulfooxy-phenyl)-ethyl]-succinamic acid | Drug Info |
| CCKBR --- CCKAR | Pyrrolidine-1-carboxylic acid (R)-3-oxo-3-(4-phenylcarbamoyl-piperidin-1-yl)-2-(3-m-tolyl-ureido)-propyl ester | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(4-chlorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-chloro-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[2-(4-hydroxy-phenyl)-acetylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chloro-N-(3,4-dichlorophenethyl)benzamide | Drug Info |
| CD221 --- JNK1 | 2-fluoro-6-(2-(5-methoxy-1-(2-(methoxy(methyl)amino)acetyl)indolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(pyridin-4-ylmethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | K00613a | Drug Info |
| CDK1 --- CDK4 | (2,6-Dichloro-phenyl)-[2-(4-methylsulfanyl-phenylamino)-imidazo[1,2-a]pyridin-6-yl]-methanone | Drug Info |
| CDK1 --- GSK3 | SID527126 | Drug Info |
| CDK1 --- GSK3 | 6-(3,4-Dimethoxy-phenyl)-7-methyl-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | 3-{4-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-propan-1-ol | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)-3-(3-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 8-(Phenylamino)-1-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(2-Methylphenylamino)-5-methylpyrimidin-4-yl}-N-{1-phenyl-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- CD221 | CHEMBL1809191 | Drug Info |
| CDK2 --- CDK1 | N-Acetyl-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-(2-Hydroxy-ethyl)-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 2-(2-aminopyrimidin-4-yl)-4-morpholinophenol | Drug Info |
| CDK2 --- CDK1 | CHEMBL1187319 | Drug Info |
| CDK2 --- CDK1 | (6-Cyclohexylmethoxy-9H-purin-2-yl)-(4-methoxy-phenyl)-amine | Drug Info |
| CDK2 --- CDK1 | 5-[(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-methyl]-thiophene-2-sulfonic acid amide | Drug Info |
| CDK2 --- CDK4 | CHEMBL485240 | Drug Info |
| CDK2 --- CDK4 | [4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-[5-(3,3-dimethyl-piperazin-1-yl)-pyridin-2-yl]-amine | Drug Info |
| CDK2 --- CDK4 | 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL99689 | Drug Info |
| CDK2 --- Cyclin E | N-[5-(2-Hydroxy-4,4-dimethyl-pentylsulfanyl)-thiazol-2-yl]-acetamide | Drug Info |
| CDK2 --- Cyclin E | 6-(3-Hydroxy-propyl)-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | 6-(4-Bromo-benzyl)-3-ethyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-9-isopropyl-N6-((3'-methoxybiphenyl-4-yl)methyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(4-tert-Butylamino-2-trifluoromethyl-quinazolin-6-yl)-formamide | Drug Info |
| CDK2 --- Cyclin E | N-[5-(5-tert-Butyl-oxazol-2-ylmethanesulfonyl)-thiazol-2-yl]-isobutyramide | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-nitro-3-(pyridin-3-yl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
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