Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5S,7R)-3-[3-(3-fluoro-phenyl)-ureido]-2-oxo-7-phenyl-5-o-tolyl-azepan-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 1-[(R)-1-(4-Benzoyl-piperidine-1-carbonyl)-3-methyl-butyl]-3-m-tolyl-urea | Drug Info |
| CD221 --- JNK1 | 2-fluoro-6-(2-(5-methoxy-1-(2-(pyrrolidin-1-yl)acetyl)indolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- AuroraA | N-(2-aminoethyl)-N-(5-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)pyridin-2-yl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(2-(7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- CDK4 | 2-(3-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-chromen-4-one | Drug Info |
| CDK1 --- GSK3 | SID516209 | Drug Info |
| CDK1 --- GSK3 | 2-Methoxy-9-nitro-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK1 --- NPKCdelta | (Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one | Drug Info |
| CDK2 --- AKT | (S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N,1,4,4-Tetramethyl-8-({4-[(4-methylpiperazin-1-yl)methyl]-phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CD221 | CHEMBL1809193 | Drug Info |
| CDK2 --- CDK1 | 4-((2-oxo-2,3-dihydropyrrolo[3,2-f]quinolin-1-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2-(5-bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(2-morpholinoethylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | N-Methyl-4-[(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-(2-Dimethylamino-ethyl)-4-[(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonyl)-3-morpholinopropanamide | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(3-Hydroxy-4-propoxybenzyl)amino]methylene}-6-iodoisoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | N-(2-(diethylamino)ethyl)-3-(4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)benzamide | Drug Info |
| CDK2 --- CDK4 | 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol | Drug Info |
| CDK2 --- CDK4 | 1-Dimethylamino-3-{4-[4-(2-fluoro-phenylamino)-pyrimidin-2-ylamino]-phenoxy}-propan-2-ol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((2-phenylthiazol-4-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | (1-(6-(biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)cyclopentyl)methanol | Drug Info |
| CDK2 --- Cyclin E | N2-(3-aminopropyl)-N6-(biphenyl-4-ylmethyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | (5-(2-chlorophenyl)-7-nitro-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepin-3-yl)methanol | Drug Info |
| CDK2 --- Cyclin E | 4-(naphthalen-1-yldiazenyl)-1H-pyrazole-3,5-diamine | Drug Info |
| CDK2 --- Cyclin E | 5-(2-fluorophenyl)-3-methyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N2-((1R,2S)-2-aminocyclohexyl)-N6-(biphenyl-4-ylmethyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | [4-(6-Methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid (2-sulfamoyl-benzothiazol-6-yl)-amide | Drug Info |
| CDK4 --- Cyclin E | 1-[3-(5-Chloro-thiophen-3-yl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | (R)-4-((1R,5S,6S,8R,11S,12S,17S)-3,12-Dihydroxy-7-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid ((R)-5-chloro-2,4-disulfamoyl-phenyl)-amide | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyrimidin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 2-Amino-N-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-acetamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(methylsulfonyl)ethyl)picolinamide | Drug Info |
| CAII --- CAI | 2-Amino-N-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-acetamide | Drug Info |
| COX2 --- 5LOX | 5-Methyl-5,6,7,8,9,10-hexahydro-cyclohepta[b]indol-2-ol | Drug Info |
| CAII --- CAI | 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-octane-1-sulfonic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| COX2 --- 5LOX | 2,6-Diisopropyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 4-[N'-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoyl)-hydrazino]-benzenesulfonamide | Drug Info |
| COX2 --- HRH1 | 11-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-Amino-N-(4-sulfamoyl-benzyl)-acetamide | Drug Info |
| CSrc --- CABL | 4-benzylidene-1-(4-iodophenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | N-Ethyl-N-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-4-nitrooxymethyl-benzamide | Drug Info |
| CSrc --- CABL | 9-(2-chlorostyryl)-N-(4-(dimethylphosphoryl)phenyl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | 4-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-ylmethyl)-benzenesulfonamide | Drug Info |
| CSrc --- CABL | 4-(4-iodobenzylidene)-1-(4-iodophenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | 4-(((1-methyl-1H-pyrrol-2-yl)methyleneamino)methyl)benzenesulfonamide | Drug Info |
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