Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | (E)-ethyl 4-(3-(6-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-4-yloxy)phenylamino)-4-oxobut-2-enoate | Drug Info |
| CAII --- CAI | SID47201870 | Drug Info |
| EGFR3 --- HER2 | N-{4-(3-Chloro-4-fluoro-phenylamino)-7-[3-(4-methyl-piperazin-1-yl)-propoxy]-pyrido[3,2-d]pyrimidin-6-yl}-acrylamide | Drug Info |
| CAII --- CAI | N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info |
| EGFR3 --- HER2 | N-(4-Bromophenylsulfonyl)-2-(4-fluorophenyl)acetamide | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (5-chloro-2,4-disulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dichloro-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylthiourea | Drug Info |
| CAII --- CAI | 4-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-methoxy-ethyl ester | Drug Info |
| EGFR3 --- HER2 | N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((2-methoxyethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| CAII --- CAI | 3-methyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| CAII --- CAI | Ethyl1-(3-(2-(1-ethoxy-1,3-dioxobutan-2-ylidene)hydrazinyl)phenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazole-4-carboxylate | Drug Info |
| CAII --- CAI | (2-{[(2,3-Dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| CAII --- CAI | 4-Benzoyl-1-(3-hydroxyphenyl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| CAII --- CAI | 4-[4-(4-Fluoro-phenyl)-[1,2,3]triazol-1-yl]-benzenesulfonamide | Drug Info |
| CAII --- CAI | 3-(Heptadecafluorooctane-1-sulfonylamino)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| CAII --- CAI | 4-(4-o-tolyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide | Drug Info |
| CAII --- CAI | 2-ethyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| CAII --- CAIX | 4-{4-[2-(4-methylhexahydro-1-pyrazinyl)ethylamino(thioxo)methylamino]phenylsulfonamido}-1-benzenesulfonamide | Drug Info |
| CAIX --- CAXII | 1-(3',5'-dimethylphenyl)-3-(4-methyl-2-oxo-2H-chromen-7-yl)urea | Drug Info |
| CALM2 --- Cathepsin B | (R)-3-Benzyloxy-N-[(S)-1-(4-benzyloxy-benzyl)-2-oxo-ethyl]-2-methanesulfonylamino-propionamide | Drug Info |
| CALM2 --- Cathepsin B | (4S)-N-(1-oxo-3-phenylpropan-2-yl)-3-tosylthiazolidine-4-carboxamide | Drug Info |
| CALM2 --- Cathepsin B | [(1S,2S)-1-((S)-1-Benzyl-2-oxo-2-phenethylcarbamoyl-ethylcarbamoyl)-2-isopropyl-cyclopropyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,3-dimethylbutan-2-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 3-Chloro-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | 5-(3-(4,5-dichloro-1H-imidazol-1-yl)prop-1-ynyl)-4-(neopentylamino)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(4-methoxyphenylamino)propan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-(4,4-dimethylcyclohexyl)-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-{(S)-2-(2-Chloro-phenyl)-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | benzyl (2S,3S)-1-(cyanomethylamino)-3-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((S)-1-(4-methoxyphenylamino)propan-2-ylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(3-hydroxy-phenyl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydarte | Drug Info |
| CCKBR --- CCKAR | (S)-2-(4-bromo-2-(quinoxaline-5-sulfonamido)benzamido)-3-(3-bromo-4-fluorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-bromo-N-phenethylbenzamide | Drug Info |
| CCKBR --- CCKAR | (R)-5-(4-Benzoyl-piperidin-1-yl)-5-oxo-4-(3-m-tolyl-ureido)-pentanoic acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(5-hydroxy-1H-indole-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid.AcOH | Drug Info |
| CCKBR --- CCKAR | (-)-2-(S)-{2-[(1H-Indole-2-carbonyl)-amino]-benzoylamino}-4-phenyl-butyric Acid | Drug Info |
| CCKBR --- CCKAR | 3-Acetylamino-N-[1-(1-{2-[1-{1-[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-carboxy-ethylcarbamoyl]-pentylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-pyrrolidine-1-carbonyl}-pentylcarbamoyl)-2-(4-sulfooxy-phenyl)-ethyl]-succinamic acid | Drug Info |
| CCKBR --- CCKAR | Pyrrolidine-1-carboxylic acid (R)-3-oxo-3-(4-phenylcarbamoyl-piperidin-1-yl)-2-(3-m-tolyl-ureido)-propyl ester | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(4-chlorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-chloro-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-((3R,5R)-8-methyl-2-oxo-5-phenyl-3-{3-[3-(1H-tetrazol-5-yl)-phenyl]-ureido}-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide | Drug Info |
| CD135 --- MCSF | MIDOSTAURIN | Drug Info |
| CD221 --- TEK | 2-[4-(1-Carboxy-2-hydroxy-propylamino)-3,6-dioxo-cyclohexa-1,4-dienylamino]-3-hydroxy-butyric acid | Drug Info |
| CDK1 --- CDK2 | GW300657X | Drug Info |
| CDK1 --- CDK2 | (Z)-4-(2-(6-bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- GSK3 | 8-Ethyl-9-oxo-8,9-dihydro-thiazolo[5,4-f]quinazoline-2-carboximidic acid isopropyl ester | Drug Info |
| CDK1 --- GSK3 | (9-Bromo-6-oxo-6,7-dihydro-5H-benzo[2,3]azepino[4,5-b]indol-12-yl)-acetic acid methyl ester | Drug Info |
| CDK1 --- GSK3 | 9-Bromo-12-(2-hydroxy-ethyl)-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
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