miRNA General Information
miRNA Mature ID hsa-miR-130b-3p
miRNA Stemloop AC MI0000748
miRNA Stemloop ID hsa-mir-130b
Sequence cagugcaaugaugaaagggcau
TTD Target(s) Regulated by This miRNA Erbb2 tyrosine kinase receptor (HER2) Successful Target Target Info [1]
Matrix metalloproteinase-2 (MMP-2) Successful Target Target Info [2]
Platelet-derived growth factor receptor alpha (PDGFRA) Successful Target Target Info [3]
Acyl-CoA desaturase (SCD) Successful Target Target Info [4]
Glucocorticoid receptor (NR3C1) Successful Target Target Info [5]
Peroxisome proliferator-activated receptor alpha (PPARA) Successful Target Target Info [4]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Target Info [6]
Signal transducer and activator of transcription 3 (STAT3) Successful Target Target Info [7]
Low-density lipoprotein receptor (LDL-R) Successful Target Target Info [5]
S-mephenytoin 4-hydroxylase (CYP2C9) Successful Target Target Info [8]
Integrin beta-1 (ITGB1) Clinical trial Target Target Info [9]
Macrophage colony-stimulating factor 1 (CSF1) Clinical trial Target Target Info [10]
Mitochondrial uncoupling protein 1 (UCP1) Clinical trial Target Target Info [4]
Insulin-like growth factor-I (IGF1) Clinical trial Target Target Info [11]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [12]
Cyclin A2 (CCNA2) Literature-reported Target Target Info [5]
Runt-related transcription factor 3 (RUNX3) Literature-reported Target Target Info [13]
Interferon regulatory factor 1 (IRF1) Literature-reported Target Target Info [14]
Protein(s) Regulated by This miRNA Coiled-coil domain-containing protein 6 Regulated Protein [15]
Delta-like protein 1 Regulated Protein [16]
Hepatocyte growth factor-like protein Regulated Protein [17]
Mothers against decapentaplegic homolog 4 Regulated Protein [12]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Regulated Protein [19]
Protein naked cuticle homolog 2 Regulated Protein [20]
Protein salvador homolog 1 Regulated Protein [17]
Synaptic functional regulator FMR1 Regulated Protein [21]
Tumor protein p53-inducible nuclear protein 1 Regulated Protein [22]
Ubiquitin carboxyl-terminal hydrolase CYLD Regulated Protein [23]
UMP-CMP kinase Regulated Protein [24]
UV radiation resistance-associated gene protein Regulated Protein [25]
Zinc finger and BTB domain-containing protein 4 Regulated Protein [12]
Zinc finger E-box-binding homeobox 1 Regulated Protein [26]
Zinc finger protein SNAI3 Regulated Protein [27]
REF 1 Up-regulation of Serum MiR-130b-3p Level is Associated with Renal Damage in Early Lupus Nephritis. Sci Rep. 2015 Aug 28;5:12644.
REF 2 MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2. Mol Carcinog. 2015 Nov;54(11):1292-300.
REF 3 Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning. J Biol Chem. 2012 Nov 9;287(46):38505-14.
REF 4 Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-. J Biomed Sci. 2015 Oct 16;22:86.
REF 5 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41.
REF 6 miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol. 2011 Feb;31(4):626-38.
REF 7 MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3. PLoS One. 2013 Sep 10;8(9):e73803.
REF 8 Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9. Drug Metab Dispos. 2015 Jun;43(6):884-8.
REF 9 MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin 1 [corrected]. PLoS One. 2014 Feb 3;9(2):e87938.
REF 10 Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1. Gynecol Oncol. 2012 Feb;124(2):325-34.
REF 11 miR-130b-3p Modulates Epithelial-Mesenchymal Crosstalk in Lung Fibrosis by Targeting IGF-1. PLoS One. 2016 Mar 8;11(3):e0150418.
REF 12 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun. 2013;4:2730.
REF 13 MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. Eur J Cancer. 2010 May;46(8):1456-63.
REF 14 Repression of microRNA-130b by thyroid hormone enhances cell motility. J Hepatol. 2015 Jun;62(6):1328-40.
REF 15 miR-130b-3p Upregulation Contributes to the Development of Thyroid Adenomas Targeting CCDC6 Gene.Eur Thyroid J. 2015 Dec;4(4):213-21.
REF 16 miR-130b-3p inhibits cell invasion and migration by targeting the Notch ligand Delta-like 1 in breast carcinoma.Gene. 2017 Apr 20;609:80-87.
REF 17 Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway.Biochem Biophys Res Commun. 2015 Sep 18;465(2):194-9.
REF 18 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun. 2013;4:2730.
REF 19 Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity.Diabetologia. 2013 Oct;56(10):2275-85.
REF 20 miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells.Biochem Biophys Res Commun. 2016 Mar 18;471(4):479-85.
REF 21 MicroRNA-130b targets Fmr1 and regulates embryonic neural progenitor cell proliferation and differentiation.Biochem Biophys Res Commun. 2013 Oct 4;439(4):493-500.
REF 22 Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1.Cancer Res. 2008 Nov 1;68(21):8976-85.
REF 23 MiR-130b inhibits proliferation and induces apoptosis of gastric cancer cells via CYLD.Tumour Biol. 2016 Jun;37(6):7981-7.
REF 24 Cytidine monophosphate kinase is inhibited by the TGF- signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.Cell Signal. 2017 Jul;35:197-207.
REF 25 p63-microRNA feedback in keratinocyte senescence.Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1133-8.
REF 26 Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.Oncogene. 2013 Jul 4;32(27):3286-95.
REF 27 MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy.Sci Rep. 2016 Feb 3;6:20475.

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