Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T52547 Target Info
Target Name Metastasis adhesion protein (MTDH)
Synonyms Protein LYRIC; Metadherin; Lysine-rich CEACAM1 co-isolated protein; LYRIC; Astrocyte elevated gene-1 protein; AEG1; AEG-1; 3D3/LYRIC
Target Type Literature-reported Target
Gene Name MTDH
UniProt ID
Q86UE4
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-30a-5p miRNA Info
miRNA Mature AC
MIMAT0000087
Sequence uguaaacauccucgacuggaag
miRNA Species Homo sapiens
Evidence Score (E-score) 3 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay; Western Blot [2]
3 Proteomics [3]
Representative Target(s) Regulated by This miRNA Beclin-1 (BECN1) Target Info
BECN1_HUMAN
Brain-derived neurotrophic factor (BDNF) Target Info
BDNF_HUMAN
miRNA Mature ID hsa-miR-145-5p miRNA Info
miRNA Mature AC
MIMAT0000437
Sequence guccaguuuucccaggaaucccu
miRNA Species Homo sapiens
Regulation Mechanism MTDH was a direct target of miR-145. [5]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; qRT-PCR; Western Blot [4]
2 Luciferase Reporter Assay; Western Blot [5]
Representative Target(s) Regulated by This miRNA A proliferation-inducing ligand (APRIL) Target Info
TNF13_HUMAN
Alkaline phosphatase (ALPPL2) Target Info
PPBN_HUMAN
miRNA Mature ID hsa-miR-630 miRNA Info
miRNA Mature AC
MIMAT0003299
Sequence aguauucuguaccagggaaggu
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; qRT-PCR; Western Blot [6]
2 PAR-CLIP [7]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Apoptosis regulator Bcl-W (BCL-W) Target Info
B2CL2_HUMAN
miRNA Mature ID hsa-miR-136-5p miRNA Info
miRNA Mature AC
MIMAT0000448
Sequence acuccauuuguuuugaugaugga
miRNA Species Homo sapiens
Regulation Mechanism miR-136 directly targets AEG-1. [8]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [8]
2 Luciferase Reporter Assay; qRT-PCR; Western Blot [9]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Interleukin-6 (IL6) Target Info
IL6_HUMAN
miRNA Mature ID hsa-miR-22-3p miRNA Info
miRNA Mature AC
MIMAT0000077
Sequence aagcugccaguugaagaacugu
miRNA Species Homo sapiens
Regulation Mechanism miR-22 targets multiple binding sites of the MTDH 3'UTR. [10]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [10]
Representative Target(s) Regulated by This miRNA 5-HT 2C receptor (HTR2C) Target Info
5HT2C_HUMAN
ATP-citrate synthase (ACLY) Target Info
ACLY_HUMAN
miRNA Mature ID hsa-miR-302c-3p miRNA Info
miRNA Mature AC
MIMAT0000717
Sequence uaagugcuuccauguuucagugg
miRNA Species Homo sapiens
Regulation Mechanism miR-302c-3p directly binds with MTDH 3'UTR at the seed sequence. [11]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [11]
Representative Target(s) Regulated by This miRNA Bone morphogenetic protein receptor (BMPR2) Target Info
BMPR2_HUMAN
Estrogen receptor (ESR) Target Info
ESR1_HUMAN
miRNA Mature ID hsa-miR-342-3p miRNA Info
miRNA Mature AC
MIMAT0000753
Sequence ucucacacagaaaucgcacccgu
miRNA Species Homo sapiens
Regulation Mechanism miR-342-3p directly targets AEG-1 with multiple binding sites. [12]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [12]
Representative Target(s) Regulated by This miRNA DNA [cytosine-5]-methyltransferase 1 (DNMT1) Target Info
DNMT1_HUMAN
E2F transcription factor 1 (E2F1) Target Info
E2F1_HUMAN
miRNA Mature ID hsa-miR-542-3p miRNA Info
miRNA Mature AC
MIMAT0003389
Sequence ugugacagauugauaacugaaa
miRNA Species Homo sapiens
Regulation Mechanism miR-542-3p might function as a tumor suppressor in gastric cancer, potentially by targeting the oncogene AEG-1. [13]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [13]
Representative Target(s) Regulated by This miRNA Angiopoietin-2 (ANGPT2) Target Info
ANGP2_HUMAN
Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
miRNA Mature ID hsa-miR-145-3p miRNA Info
miRNA Mature AC
MIMAT0004601
Sequence ggauuccuggaaauacuguucu
miRNA Species Homo sapiens
Regulation Mechanism MTDH was regulated by miR-145-3p in lung SCC. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [4]
Representative Target(s) Regulated by This miRNA Matrix metalloproteinase-16 (MMP-16) Target Info
MMP16_HUMAN
Metastasis adhesion protein (MTDH) Target Info
LYRIC_HUMAN
miRNA Mature ID hsa-miR-506-5p miRNA Info
miRNA Mature AC
MIMAT0022701
Sequence uauucaggaagguguuacuuaa
miRNA Species Homo sapiens
Regulation Mechanism AEG was a direct and functional downstream target of miR-506. [14]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [14]
Representative Target(s) Regulated by This miRNA Beta-catenin (CTNNB1) Target Info
CTNB1_HUMAN
Metastasis adhesion protein (MTDH) Target Info
LYRIC_HUMAN
References  Top
REF 1 MiR-30a-5p suppresses cell growth and enhances apoptosis of hepatocellular carcinoma cells via targeting AEG-1. Int J Clin Exp Pathol. 2015 Dec 1;8(12):15632-41.
REF 2 MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene. 2014 Jun 12;33(24):3119-28.
REF 3 Widespread changes in protein synthesis induced by microRNAs.Nature. 2008 Sep 4;455(7209):58-63.
REF 4 Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma. Oncotarget. 2016 Nov 1;7(44):72084-72098.
REF 5 MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer. Med Oncol. 2015 Jan;32(1):344.
REF 6 MiR-630 suppresses breast cancer progression by targeting metadherin. Oncotarget. 2016 Jan 12;7(2):1288-99.
REF 7 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 8 MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2. FEBS Lett. 2012 Oct 19;586(20):3608-12.
REF 9 MiR-136 modulates glioma cell sensitivity to temozolomide by targeting astrocyte elevated gene-1. Diagn Pathol. 2014 Sep 30;9:173.
REF 10 microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer. Mol Med Rep. 2015 Jan;11(1):454-60.
REF 11 MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin (MTDH) expression. Cancer Biol Ther. 2015;16(9):1308-15.
REF 12 Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p. Lab Invest. 2017 Apr;97(4):447-457.
REF 13 MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1. Med Oncol. 2015 Jan;32(1):361.
REF 14 Overexpression of miR-506 suppresses proliferation and promotes apoptosis of osteosarcoma cells by targeting astrocyte elevated gene-1. Oncol Lett. 2016 Sep;12(3):1840-1848.

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