Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-2-naphthamide | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-4-(4-methoxy-phenyl)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-fluoro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | [7-Bromo-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP3 | 4-((2-methylquinolin-4-yl)methoxy)-N-((5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzenesulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-bromobenzamide | Drug Info |
| Ftase --- FPTase | 6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-methyl-amino}-methyl)-3''-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(benzhydrylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-3-(3-amino-propyl)-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[(3-Cyclohexylmethyl-3H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4-(1H-indol-2-yl)-phenyl]-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-(trifluoromethyl)-4-biphenylol | Drug Info |
| Ftase --- FPTase | (S)-2-({(R)-2-[(S)-2-((R)-3-Mercapto-2-methyl-propionylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP8 | pentan-3-ylcarbamoylphosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(4-hydroxyphenyl)-2-methyl-6-morpholino-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,3-dimethyl-but-1-ynyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-fluoro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Thiophene-6-methyl-N-(4-trifluoromethylphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[6-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| MMP2 --- MMP9 | 2-amino-N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829257 | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-N-hydroxy-3-(4-(4-methoxyphenoxy)phenylsulfonyl)thiazolidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-4-methyl-N-(1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[(Furan-2-ylmethyl)-amino]-methyl}-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid cyclopropyl ester | Drug Info |
| Lck --- VEGFR | 6-o-tolylquinazolin-2-amine | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-(pyridin-3-yloxy)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-isopropyl-4-phenoxybenzenesulfonamide | Drug Info |
| Src --- VEGFR | CHEMBL371688 | Drug Info |
| Ftase --- FPTase | [(S)-4-(3H-Imidazol-4-ylmethyl)-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-(4-Cyanobenzoyl))piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR1 --- FGFR1 | 3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-(2-cyclopropoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-Hydroxy-phenyl)-5-methyl-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR2 --- CABL | (E)-3-(5-((Z)-4-Methyl-3-oxo-3,4-dihydrobenzo[b][1,4]oxazin-2-ylidenemethyl)thiophen-2-yl)-N-(pyridin-3-ylmethyl)acrylamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-(1-oxy-pyridin-3-yl)-propan-1-one | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-[4-(4-nitro-benzoylamino)-benzenesulfonylamino]-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenoxy)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-(2-ethyl-1H-imidazol-1-yl)ethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-bromobenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- Ckit | OSI-930 | Drug Info |
| Ftase --- FPTase | 9-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-1-(3-chloro-phenyl)-6,7-dihydro-5H-pyrido[3,2,1-ij]quinolin-3-one | Drug Info |
| MMP3 --- MMP8 | 2-(4'-Chloro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-(2-piperazin-1-yl-ethyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP3 --- MMP8 | [4-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid ethyl ester | Drug Info |
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