Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-3-yl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-4-(4-Acetylpiperazin-1-yl)but-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-morpholinoethoxy)phenyl)nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-amino-3-methylbutyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-chlorobenzamide | Drug Info |
| Ftase --- FPTase | N-Isobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-methyl-6-(trifluoromethyl)-9H-carbazole | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-methyl-allyl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-[(4-Methyl-1H-indol-5-yl)amino]-5-{(1E)-4-[4-(methylsulfonyl)piperazin-1-yl]but-1-en-1-yl}nicotinonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxyphenyl)-N,N,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-4-carboxylic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Src --- VEGFR | N-(3-chloro-6-methoxypyridin-2-yl)-7-(3-morpholinopropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| GSK --- VEGFR | Cyclopropanecarboxylic acid [6-(4-chloro-phenyl)-furo[2,3-d]pyrimidin-4-yl]-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-phenyl-thiazol-2-ylmethyl)-phenylamino]-3-cyano-7-methoxy-quinolin-6-yl}-amide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((4-hydroxypiperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR1 --- FGFR1 | 2-(7-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazole | Drug Info |
| H3 --- SERT | 7-(3-(4-ethylpiperazin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(3-(piperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 1-(4-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yloxy)ethyl)piperazin-1-yl)ethanone | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645107 | Drug Info |
| VEGFR2 --- CD135 | (3S,5R)-5-bromo-16-hydroxy-14-methoxy-3-methyl-3,4,5,6,9,10,11,12-octahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-(4-Chlorophenylsulfonyl)-2-(4-fluorophenyl)acetamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-(methylamino)ethyl)phenyl)pyrimidin-2-amine | Drug Info |
| H3 --- SERT | 3-(3-methoxyphenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-aminopyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-carboxylic acid | Drug Info |
| HD6 --- HDAC4 | 2,2,2-trifluoro-1-(5-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(3-(morpholinomethyl)phenyl)pyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 2-(4-hydroxy-benzyl)-cyclopentyl ester | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | Drug Info |
| HDAC1 --- HD6 | 1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-carbonyl)thiophen-2-yl)-2,2,2-trifluoroethanone | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(1-methyl-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PKCA --- NPKC delta | 3-(1H-Indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione | Drug Info |
| VEGFR2 --- Cmet | (S)-N-(4-(2-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-[4-(N-4-methoxy-phenyl-N-methyl-sulfamoyl)-phenyl]-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(quinolin-4-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PKCA --- NPKC delta | 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-isobutyl-5-methyl-hex-(E)-ylidene]-5-thioxo-tetrahydro-furan-2-ylmethyl ester | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)-N-hydroxyhexanamide | Drug Info |
| EGFR3 --- HER2 | {6-[2-(2-Methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-amine | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.