Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| mTOR --- AKT | N-(6-(2-(4-Methoxyphenylsulfonamido)pyridin-4-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | {2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | (S)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-(1-oxy-pyridin-4-yl)-propan-1-one | Drug Info |
| mTOR --- PI3K gamma | Isopropyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpholino-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-(4-morpholin-4-ylphenyl)urea | Drug Info |
| Ftase --- FPTase | 2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-methoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| Ftase --- FPTase | 19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| NET --- SERT | 3-methoxy-5,6-dihydrobenzo[c]acridin-7-amine | Drug Info |
| Ftase --- FPTase | 2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-tetradecanoic acid | Drug Info |
| NET --- SERT | 3-Piperidin-4-ylmethyl-1H-indole | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(3-(1H-imidazol-5-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-thiophen-2-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-cyclopentylpiperazin-1-yl)methyl)furan-3-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | ethyl 2-(5-methyl-3-(3-(1-methyl-1H-imidazol-5-yl)propyl)-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetate | Drug Info |
| NPKCdelta --- NPKCtheta | (R)-2-(3-(3-(dimethylamino)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-{3-[1-methyl-2-oxo-3-(3,3,3-trifluoro-propyl)-azepan-3-yl]-phenoxy}-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((2,3-dihydroxypropylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-piperidin-1-yl-methanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-isopropylpiperazin-1-yl)methyl)furan-3-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| GSK --- VEGFR | 4-amino-5-(4-(benzenesulfonylamino)-phenyl)-6-(3-pyridyl)-furo[2,3-d]pyrimidine | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(pent-2-ynyloxy)-4-((5-(trifluoromethyl)pyridin-2-yloxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| H3 --- SERT | 3-(3-bromophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid,(3S)-3-morpholinylmethyl ester | Drug Info |
| PI3K gamma --- PI3K delta | (3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenyl)methanol | Drug Info |
| PR --- mRNA of AR | (6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)-methyl-17-(2-oxo-propyl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one | Drug Info |
| H3 --- SERT | 3-(4-fluorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Ethynyl-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PR --- mRNA of AR | 2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| H3 --- SERT | 4-(4-chloro-3-fluorophenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(naphthalen-1-yl)acrylate | Drug Info |
| PI3K gamma --- PI3K delta | 6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-2-pyridin-4-yl-thieno[3,2-d]pyrimidine | Drug Info |
| PR --- mRNA of AR | N-{3-[Benzyl-(4-chloro-2-fluoro-benzyl)-amino]-2-methyl-phenyl}-methanesulfonamide | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-4-(4-morpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-bromo-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-5-(4-morpholinyl)-2-pentynamide | Drug Info |
| PI3K gamma --- PI3K delta | 4-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-phenylamine | Drug Info |
| PR --- mRNA of AR | (5aS,7S)-3-Methyl-7-(1-(quinolin-6-ylmethylamino)propan-2-yl)-6,7,8,9-tetrahydropyrano[4,3-b]chromen-1(5aH)-one | Drug Info |
| HD6 --- HDAC4 | N-benzyl-N-methyl-4-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | EGFR_ErbB_2_ErbB_4_Inhibitor | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-(2-hydroxy-6-methoxycarbonyl-benzoyl)-benzoic acid 2-(4-hydroxy-benzyl)-cyclopentyl ester | Drug Info |
| PR --- mRNA of AR | 2'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitrile | Drug Info |
| HDAC1 --- HD6 | (2E,4E,8E)-9-Benzo[1,3]dioxol-5-yl-nona-2,4,8-trienoic acid hydroxylamine | Drug Info |
| EGFR3 --- HER2 | (R)-7-(4-(1-(4-Fluorophenyl)ethylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.