Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP13 | CHEMBL1738748 | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-phenyl-phenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((4-(3-chlorophenyl)-2-(2-(methylsulfonyl)ethyl)-5-oxopiperazin-1-yl)methyl)-4-methyl-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP13 | 3-(5-(benzyloxy)-1H-indol-3-yl)-2-(4-(but-2-ynyloxy)phenylsulfonamido)propanoic acid | Drug Info |
| PR --- mRNA of AR | (+/-)-1-(cyclopropylmethyl)-2-ethyl-1,2,3,6-tetrahydro-9-(trifluoromethyl)-7H-[1,4]oxazino[3,2-g]quinolin-7-one | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-2-((S)-2-{2-[Hydroxy-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienyl)-carbamoyl]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyrylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-2-(3-cyclohexylpropyl)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)-N4-hydroxysuccinamide | Drug Info |
| PR --- mRNA of AR | 5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-1-hydroxy-2-methylpropan-2-yl oxime | Drug Info |
| Ftase --- FPTase | 1-{3-(4-Cyano-phenyl)-2-[(3-methyl-3H-imidazol-4-ylmethyl)-amino]-propionyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-methyl-2-{4-[2-methyl-3'-(2-methylamino-ethoxy)-biphenyl-4-yl]-piperidine-1-sulfonyl}-propionamide | Drug Info |
| PR --- mRNA of AR | 5-Bromo-2-((1S,4R)-4-hydroxymethyl-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid propylamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-6-(4'-fluoro-biphenyl-4-yl)-hexanoic acid | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1,3-bis(3-fluorophenyl)propan-1-one | Drug Info |
| Ftase --- FPTase | 3-Benzyl-4-(2-dimethylamino-ethanesulfonyl)-1-(3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-propyl)-N*1*-hydroxy-3-isobutyl-succinamide | Drug Info |
| PR --- mRNA of AR | CHEMBL414318 | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[((E)-2-pyrimidin-5-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(3'-Amino-biphenyl-4-yl)-2-butyl-4-((S)-2,2-dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| PR --- mRNA of AR | 5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-isopropyl oxime | Drug Info |
| Ftase --- FPTase | 4-{5-[(3-Oxo-2-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-{(S)-1-hydroxycarbamoyl-2-[methanesulfonyl-(4-p-tolyloxy-phenyl)-amino]-ethyl}-isobutyramide | Drug Info |
| Renin --- Cathepsin D | 2-(2-Amino-thiazol-4-ylmethyl)-N*4*-cyclohexylmethyl-N*1*-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N*4*-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide (BILA 2157 BS) | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methoxy-benzyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(2-p-tolylethynyl)phenyl)methan-8-ylsulfonamido)propanamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,7aR,8aS,8bS,8cS,10aS)-N,N-diethyl-5,8b,10a-trimethyl-7-oxo-1,2,3,3a,3b,4,5,7,7a,8,8a,8b,8c,9,10,10a-hexadecahydrocyclopenta[i]cyclopropa[a]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydroxy-prop-1-ynyl}-3''-methoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-methylbenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid tert-butylamide | Drug Info |
| Ftase --- FPTase | [[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-acetic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(cyclopropylmethyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | 17-Diisopropylcarbamoyl-13-methyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | 2-[1-(2-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | N-(1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)propan-2-yl)-N-hydroxyformamide | Drug Info |
| S5AR --- SRD5A2 | 5-Bromo-pentanoic acid pentyl-((4aR,6aS,7S,11aR)-1,4a,6a-trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinolin-7-yl)-amide | Drug Info |
| Ftase --- FPTase | N-(5-cyano-2-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)phenyl)-4-methylbenzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-1-(2,6-Difluoro-benzoyl)-9a,11a-dimethyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridin-7-one | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid benzylamide | Drug Info |
| MMP2 --- MMP9 | (S)-2-(4-(4-chlorophenyl)piperazin-1-yl)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-7-(Indole-1-carbonyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Ftase --- FPTase | 2-(2-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(4-(trifluoromethoxy)benzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-1-(3-methylbutanoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| Ftase --- FPTase | 4-allyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-(4-chlorophenyl)acetyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | 9,10-Dihydro-phenanthrene-2-carboxylic acid | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-phenoxy-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 3-hydroxy-1-((4-(p-tolyloxy)phenylsulfonyl)methyl)pyridin-2(1H)-one | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
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