Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HER2 --- CD221 | 2,6-difluoro-N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 4-(3-Phenyl-1H-indol-2-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-(4-(3-(2-benzoyl-4-ethylphenoxy)butoxy)phenoxy)-2-methylpropanoic acid | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(pyrrolidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | 4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazine-1-carboxylic acid (4-chloro-phenyl)-amide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(1-(4-tert-butylbenzyl)-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-ethynylpicolinamide | Drug Info |
| Erbeta --- ER | (3S,10S,13S,17S)-10-(hydroxymethyl)-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-methoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenylmethyl}hexanoic aci | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-methylphenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | rac-9a-butyl-6-cyclopropyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-4,6-difluorobiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(thiophen-3-yl)picolinamide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 5-methyl-2-(3-(7-methyl-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-(trifluoromethyl)quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 10-bromo-3-hydroxy-4,8-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((R)-3-(4-chloro-2-(pyridin-2-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 6-hydroxy-3-{4-[2-(1-piperidinyl) ethoxy]phenoxy}-2-(4-aminophenyl)benzo[b] thiophene | Drug Info |
| PPAR gamma --- PPAR delta | 2-(7-(4-(benzyloxy)benzylthio)-2,3-dihydro-1H-inden-4-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | 4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-2-methyl-phenyl)-benzo[b]thiophen-6-ol | Drug Info |
| JNK1 --- JNK3 | methyl 3-(2-(quinolin-5-yl)acetamido)thiophene-2-carboxylate | Drug Info |
| Erbeta --- ER | 5-hydroxy-2-(6-hydroxybenzo[d]isoxazol-3-yl)benzaldehyde oxime | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-(2-((benzylamino)methyl)thiophen-3-yl)-5-cyanopicolinamide | Drug Info |
| Erbeta --- ER | N-(2-(4-methoxyphenyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)benzamide | Drug Info |
| JNK1 --- JNK3 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)acetamide | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-carbaldehyde | Drug Info |
| MEP --- Cathepsin B | [(3-Bromophenyl)-(3-acetoxyphenyl)-ketone]thiosemicarbazone | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MEP --- Cathepsin B | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-1-naphthamide | Drug Info |
| Erbeta --- ER | (2-Phenyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; hydrochloride | Drug Info |
| MEP --- Cathepsin B | 4'-Iodo-biphenyl-4-carboxylic acid {1-[(S)-1-(2-diazo-acetyl)-butylcarbamoyl]-3-methyl-butyl}-amide | Drug Info |
| Erbeta --- ER | 3-hydroxy-9-methoxy-4,8,10-trimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-3,3,3-trifluoropropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide | Drug Info |
| Erbeta --- ER | 2-(3-Fluoro-4-hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| MEP --- Cathepsin B | 1-((3,5-bis(trifluoromethyl)phenyl)(thiophen-2-yl)methylene)thiosemicarbazide | Drug Info |
| Erbeta --- ER | 4-[5-(4-hydroxy-phenyl)-4-ethyl-3-(4-methoxy-phenyl)-furan-2-yl]-phenol | Drug Info |
| Met --- VEGFR | N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-(4-hydroxy-phenyl)-5-pentyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| Met --- VEGFR | (S)-N-(3-fluoro-4-(2-(4-((N-(1-methoxypropan-2-yl)acetamido)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | 5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-carboxy-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester | Drug Info |
| Erbeta --- ER | 3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol-3-yl]-3-methylpiperazine-1-sulfonylamino}-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| PR --- mRNA of AR | N-(1-Difluoromethoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-3,4-dihydro-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-[(S)-1-(5,6-Dichloro-1H-benzoimidazol-2-yl)-3-methyl-butyl]-N*4*-hydroxy-2-isobutyl-succinamide | Drug Info |
| PR --- mRNA of AR | (5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methanol | Drug Info |
| Erbeta --- ER | 5-hydroxynaphthalen-1-yl 2,4-dichlorobenzoate | Drug Info |
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