Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Renin --- Cathepsin D | {1-[1-[2-(5-Benzyloxymethyl-1-methyl-2-oxo-pyrrolidin-3-yl)-1-cyclohexylmethyl-2-hydroxy-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | 5-Hydroxy-2-(4-hydroxy-phenyl)-3-phenyl-inden-1-one | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Chloro-2,3-dihydro-1H-pyrrolo[3',4':4,5]imidazo[1,2-a]pyridine-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(1-methyl-2-oxo-5-vinyl-pyrrolidin-3-yl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | 4-chloro-2-(4-hydroxyphenyl)quinolin-6-ol | Drug Info |
| MMP1 --- MMP3 | 1N-phenyl-4-amino-2-[1-[1-amino-(1R)-ethylcarboxamido]-3-phenyl-(1S)-propylcarboxamido]pentanamide | Drug Info |
| S5AR --- SRD5A2 | 17-Diisopropylcarbamoyl-13-methyl-12,13,14,15,16,17-hexahydro-11H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-3-Isopropyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP1 --- MMP3 | {(S)-3-[(R)-2-((R)-1-Hydroxycarbamoyl-ethyl)-4-methyl-pentanoylamino]-2-oxo-azepan-1-yl}-acetic acid methyl ester | Drug Info |
| S5AR --- SRD5A2 | (4aR,10bR)-4,10b-Dimethyl-8-((E)-2-quinolin-2-yl-vinyl)-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| Erbeta --- ER | 2-(3-Fluoro-4-hydroxy-phenyl)-benzo[b]thiophene-4,6-diol | Drug Info |
| MMP1 --- MMP9 | 12-Isobutyl-8,13-dioxo-1,7diaza-cyclotridecane-2,11-dicarboxylic acid 11-hydroxyamide 2-methylamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (2-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 3-(4-(6-hydroxy-3-octyl-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-cyclopropylacetamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (4-benzoyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 1-[N-4-(3,4,6-Tri-O-acetyl-2-fluoro-2-deoxy-beta-D-glucopyranosyloxy)phenyl-N-methyl]carbamoyl-5-fluorouracil | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-1-ethyl-N-hydroxy-1,4-diazepane-5-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-6-chloro-N,N-diethyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 5-hydroxy-2-(5-hydroxynaphthalen-1-yl)isoindoline-1,3-dione | Drug Info |
| MMP13 --- MMP1 | 4-{(R)-Carboxy-[5-(4'-methoxyphenyl)-thiophene-2-sulfonylamino]-methyl}-piperidine-1-carboxylic Acid iso-Propyl Ester | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-diisopropyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 2,2,2-Trifluoro-1-[(S)-6-hydroxy-1-(4-hydroxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone | Drug Info |
| MMP13 --- MMP1 | (2S,3R)-2-Methyl-4-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-piperazine-1,3-dicarboxylic acid 3-hydroxyamide 1-isopropylamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-N-hydroxy-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-benzenesulfonyl]-3-methyl-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-5-methoxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 4-Ethyl-2-(3-fluoro-4-hydroxy-phenyl)-quinolin-6-ol | Drug Info |
| MMP13 --- MMP1 | 1-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-cyclopropanecarboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2,3-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP14 | N-(4-((4-(4-fluorophenyl)piperazin-1-ylsulfonyl)methyl)-1-methylpiperidin-4-yl)-N-hydroxyformamide | Drug Info |
| FGFR --- Src | N-{6-(2,6-Dichloro-phenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-butyramide | Drug Info |
| Erbeta --- ER | 2-Phenyl-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophene-6-carboxylic acid methyl ester | Drug Info |
| MMP13 --- MMP9 | 4-(4-butoxyphenylsulfonyl)-1-butyl-N-hydroxypiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-4-(2,5-difluorophenyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Erbeta --- ER | SID14722491 | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-9-oxo-8-[3-(3,4,5-trimethoxy-phenyl)-propyl]-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-8-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Erbeta --- Mcl1 | SID85302452 | Drug Info |
| MMP2 --- MMP13 | 2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenylsulfanyl-benzenesulfonyl)-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829409 | Drug Info |
| FGFR --- PDGFR | 1-(2-amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea | Drug Info |
| MMP2 --- MMP13 | 5-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonylamino)-pent-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-(2-mercapto-ethoxy)-ethyl ester | Drug Info |
| Ftase --- FPTase | N-(adamantan-2-yl)-10-cyano-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.1^{3,7}.1^{9,13}.0^{15,19}]heptacosa-3(27),4,6,9(26),10,12,16,18-octaene-4-carboxamide | Drug Info |
| MMP2 --- MMP13 | N-((2S,4S)-4-(5-fluoropyrimidin-2-yl)-2-methyl-1-(4-(2-(3-methyl-5-(trifluoromethyl)pyridin-2-yl)ethyl)piperidin-1-ylsulfonyl)pentan-2-yl)-N-hydroxyformamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-[3-(1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
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