Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | (R)-3-{(S)-4-[(E)-5-(4-{5-[4-(2-Carboxy-2-ethoxy-ethyl)-phenoxy]-3-methyl-pent-3-en-1-ynyl}-phenyl)-3-methyl-pent-2-en-4-ynyloxy]-phenyl}-2-ethoxy-propionic acid | Drug Info |
| PR --- mRNA of AR | 7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| HDAC1 --- HDAC2 | N-hydroxy-7-(5-(4-methoxyphenyl)oxazol-2-yl)heptanamide | Drug Info |
| Erbeta --- ER | 4-[1-(1-Methyl-butyl)-1,7a-dihydro-pyrrolo[2,1,5-cd]indolizin-2-yl]-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 3-(1-((2-(3,5-dimethoxyphenyl)-5-methyloxazol-4-yl)methyl)-1H-indol-5-yl)-2-ethoxypropanoic acid | Drug Info |
| PR --- mRNA of AR | Methyl 2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(2-chloro-4-fluorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate | Drug Info |
| HDAC1 --- HDAC2 | 6-Methoxy-1H-indole-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | 4-[4-(2-hexahydro-1-pyridinylethoxy)phenyl]-3-phenyl-(3S,4R)-3,4-dihydro-2H-7-chromenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-{4-[3,3-Bis-(4-furan-2-yl-phenyl)-allyloxy]-phenyl}-2-ethoxy-propionic acid | Drug Info |
| Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-4-(3-methoxy-propyl)-2,15-dioxo-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(3,4-Dimethoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | (2S,3S)-3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| PPAR gamma --- PPAR delta | 4-{4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-butyric acid | Drug Info |
| Renin --- Cathepsin D | (S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-isobutylcarbamoyl-hexyl)-2-(3-methyl-butyrylamino)-succinamic acid | Drug Info |
| HDAC1 --- HDAC2 | Thailandepsin B | Drug Info |
| Erbeta --- ER | 4-hydroxy-N-(4-hydroxyphenyl)-N-(3,3,3-trifluoropropyl)benzenesulfonamide | Drug Info |
| PPAR gamma --- PPAR delta | 3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,10S)-1-Allyl-7-(1,5-dimethyl-hexyl)-4a,6a,10-trimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| HDAC1 --- HDAC4 | (R)-N2-hydroxy-N5-(1-phenylethyl)thiophene-2,5-dicarboxamide | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylselanyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(3,5-bis(trifluoromethyl)phenyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| HER2 --- CD221 | trans-N-(4-(4-amino-1-(4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | [5-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | {4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-acetic acid | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-1,4a,6a-trimethyl-10-phenyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 1-(4-bromophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{5-[5-(7-propyl-3-trifluoromethylbenzo[d]isoxazol-6-yloxy)pentyloxy]-1H-indol-1-yl}ethanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (4-chloro-phenyl)-cyclopentyl-amide | Drug Info |
| JNK1 --- JNK3 | 3-Morpholino-5-(2-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)-phenylamino)pyrimidin-4-yl)benzonitrile | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-pentan-3-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(4-hydroxybut-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-1-ylamide | Drug Info |
| JNK1 --- JNK3 | methyl 4-ethyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate | Drug Info |
| JNK1 --- JNK3 | CHEMBL205078 | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-chloro-4-(5-methyl-4-((2-(2-nitro-4-(trifluoromethyl)phenoxy)ethyl)carbamoyl)isoxazol-3-yl)phenyl)acetic acid | Drug Info |
| S5AR --- SRD5A2 | 3-(17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-propionic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 4,4'-(pent-3-yne-1,2-diyl)diphenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{5-[3-(3-phenyl-7-propylbenzo[d]isoxazol-6-yloxy)propoxy]-indol-1-yl}ethanoic acid | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid p-tolyl ester | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-tert-butoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 5-hydroxy-2-(4-hydroxynaphthalen-1-yl)isoindoline-1,3-dione | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-ethyl-2-(pyridin-4-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| ABL --- Src | (2,4-Dichloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| JNK1 --- JNK3 | SID103904794 | Drug Info |
| Erbeta --- ER | rac-9a-butyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| ABL --- Src | (4-tert-Butoxy-3,5-dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
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