Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-(5-{[2-(3-Methoxy-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{3-methyl-3-[4-(4-nitro-benzyloxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-methyl 2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoate | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-ethoxy-benzyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-2-Amino-N-hydroxy-2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-tert-butyl-4'-ethynyl-3-methylbiphenyl | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-nitro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-(3-aminopropyl)-4-(2,5-difluorophenyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Ftase --- FPTase | 6-[(3-chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-4-(pyridin-2-yloxy)benzenesulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(4'-(3-(trifluoromethyl)-3H-diazirin-3-yl)biphenyl-4-yl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-5,6,7,8-tetrahydro-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Dimethylamino-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4'-(2,2,2-trifluoroethyl)-4-biphenylyl]methanesulfonamide | Drug Info |
| Ftase --- FPTase | 2-(Biphenyl-2-yloxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP3 --- MMP8 | [2-(4-Benzooxazol-2-yl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Lck --- VEGFR | N-(2-(3,3-dimethyl-2-oxoazetidin-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-methoxy-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP3 --- MMP8 | 2-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophene-2-sulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Src --- VEGFR | [6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-(1-methyl-1H-indol-4-yl)-amine | Drug Info |
| Ftase --- FPTase | 15-benzyl-16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| mTOR --- AKT | N-(6-(3-(4-Methoxyphenylsulfonamido)phenyl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | ((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphonic acid | Drug Info |
| mTOR --- AKT | N-(6-(2-(N-Ethyl-4-methoxyphenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- BRaf | 3,3-Dimethyl-6-(6-methyl-5-(2-(methylamino)quinazolin-6-yl)isoquinolin-1-ylamino)indolin-2-one | Drug Info |
| Ftase --- FPTase | 4-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(2-(3-(hydroxymethyl)phenyl)-6-morpholino-9H-purin-9-yl)piperidin-1-yl)ethanone | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(4-ethylpiperazin-1-yl)ethyl)phenyl)-4-(1H-indol-6-yl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-4'-(trifluoromethoxy)biphenyl-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-(4-Dimethylaminophenyl)-3-[4-(3-isopropyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]-urea | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-methoxyphenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 16,18-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide | Drug Info |
| VEGFR2 --- Ckit | 6,6-Dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 6-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-6-oxo-hexanoic acid methyl ester | Drug Info |
| mTOR --- PI3K gamma | N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyrimidin-5-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| NET --- SERT | 6,7,8,9,10,11-hexahydrocycloocta[b]quinolin-12-amine | Drug Info |
| VEGFR2 --- Cmet | 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(4-fluorophenyl)butanamide | Drug Info |
| Ftase --- FPTase | 8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-6-(3-chloro-phenyl)-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | Drug Info |
| NET --- SERT | 5-Bromo-3-piperidin-4-ylmethyl-1H-indole | Drug Info |
| VEGFR2 --- Cmet | N1-(3-fluoro-4-(2-(1-methyl-1H-imidazole-2-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-fluoro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3-methoxystyryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- CSrc | 3-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(4-phenyl-butoxy)-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(2-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)pyridin-3-yl)vinyl)-N,N-diisopropylbenzenesulfonamide | Drug Info |
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