Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-(but-1-en-3-ynyl)-6-ethoxypicolinamide | Drug Info |
| Erbeta --- ER | 6-(2-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-[3-[2-[2-(2-Chlorophenyl)-5-hexyl-4-oxazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(4-(pyridin-4-yl)phenyl)acetamide | Drug Info |
| Erbeta --- ER | 3-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)benzonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylselanyl)-2-methylphenoxy)butanoic acid | Drug Info |
| JNK1 --- JNK3 | 3-methoxy-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)propanamide | Drug Info |
| Erbeta --- ER | 3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid [4-(2-chloro-acetyl)-phenyl]-amide | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromene-2,8-diol | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-dip-tolylallyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| Erbeta --- ER | 3-phenyl-4-[4-(2-tetrahydro-1H-1-pyrrolylethoxy)phenyl]-(3S,4R)-3,4-dihydro-2H-7-chromenol | Drug Info |
| JNK1 --- JNK3 | 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyanophenyl)-1-isopropyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| Erbeta --- ER | 4-{(Z)-1-[4-(2-Diethylamino-ethoxy)-phenyl]-2-ethyl-hex-1-enyl}-phenol; compound with 4-{(E)-1-[4-(2-diethylamino-ethoxy)-phenyl]-2-ethyl-hex-1-enyl}-phenol | Drug Info |
| MEP --- Cathepsin B | 4'-(1-Methyl-piperidin-3-yloxy)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-phenylpropan-1-one | Drug Info |
| Erbeta --- ER | 3-(3-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | 4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)-pentanoic acid cyanomethyl-amide | Drug Info |
| PR --- mRNA of AR | (+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol | Drug Info |
| Erbeta --- ER | 4-{2-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylsulfanyl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MEP --- Cathepsin B | 4'-(1-Methyl-piperidin-4-yloxy)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PR --- mRNA of AR | rac-4-(1-(4-fluorobenzyl)-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)benzonitrile | Drug Info |
| Erbeta --- ER | 4-{2-[4-(3-Phenyl-propylamino)-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(1,4-dimethylpiperidin-4-yl)thiazol-4-yl)benzamide | Drug Info |
| PR --- mRNA of AR | (R)-Methyl 2-((1H-Tetrazol-1-yl)methyl)-4-(2-chloro-4-fluorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate | Drug Info |
| Erbeta --- ER | (S)-9a-ethyl-6-phenyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| MEP --- Cathepsin B | [(3,4,5-Trimethoxyphenyl)-(4-methoxy,5-hydroxyphenyl)-ketone]thiosemicarbazone | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-bromophenyl)-3-cyclohexylpropan-1-one | Drug Info |
| Erbeta --- ER | 4,10-dimethyl-6H-benzo[c]chromene-3,8-diol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(methylthio)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| PR --- mRNA of AR | 6,8,8,9-Tetramethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-benzo[b]thiophen-6-ol; hydrochloride | Drug Info |
| Met --- VEGFR | N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Drug Info |
| PR --- mRNA of AR | (5bR,9aR)-1-Methyl-10-propyl-4-trifluoromethyl-1,5b,6,7,8,9,9a,10-octahydro-pyrido[2,3-b]carbazol-2-one | Drug Info |
| Erbeta --- ER | 3,7,9-Trihydroxy-5,11-dioxa-benzo[b]fluoren-10-one | Drug Info |
| Met --- VEGFR | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide | Drug Info |
| Renin --- Cathepsin D | N-(1-Cyclohexylmethyl-2,4-dihydroxy-hexyl)-3-[2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-succinamic acid methyl ester | Drug Info |
| Erbeta --- ER | (2-Cyclohexyl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-2-[4-(4-tert-Butyl-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| S5AR --- SRD5A2 | SID49645845 | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-isopropyl-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-oxo-1-(2-phenoxy-ethyl)-azepan-3-yl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | 8-Chloro-4-methyl-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-3-methyl-1,2'-spirobi[1H-indene]-5-ol | Drug Info |
| MMP1 --- MMP3 | (R)-2-[4-(4-Chloro-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-5,6,9a,11a-Tetramethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-1-ylamide | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-5-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-(4-ethylphenyl)acetamide | Drug Info |
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