Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((4-((3-(1-piperidinyl)propyl)oxy)phenyl)amino)-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentylamino]-3-methyl-pentanoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- CSrc | CHEMBL436968 | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2-Methyl-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 1-((4-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl)phenyl)thiophen-2-yl)methyl)-4-methylpiperazine | Drug Info |
| VEGFR2 --- EGFR3 | 2-(3-methoxybenzyloxy)-5-(6-methoxy-7-(2-methoxyethoxy)quinazolin-4-ylamino)cyclohexa-2,5-diene-1,4-dione | Drug Info |
| Ftase --- FPTase | 1-[(1R,2R)-1-(2-Chloro-thiophen-3-ylmethoxy)-1,2,6,7,8,9-hexahydro-naphtho[2,1-b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(2-methoxystyryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- FGFR1 | N-(5-Benzyloxy-pentyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| GSK --- VEGFR | 2-Cyclopentyl-N-[6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-yl]-acetamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-3-yl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N',N'-dimethylacrylohydrazide | Drug Info |
| VEGFR2 --- STK1 | 5-(1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-3-(1H-imidazol-4-yl)-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4-hydroxy-5-methoxy-1H-benzimidazole | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-3-(1,1,2,2-tetrafluoroethoxy)benzamide | Drug Info |
| H3 --- SERT | N-methyl(5-(4-morpholinobut-1-ynyl)-2-phenoxyphenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-morpholino-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- TEK | 3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-phenylurea | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 1-(5-Chloro-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylthiourea | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957840 | Drug Info |
| VEGFR2 --- TEK | 1-(3-(2-aminoquinazolin-6-yl)-4-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl ethyl carbonate | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(3-aminopropyl)-3-methyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(2-(quinoxalin-2-yl)ethynyl)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| HD6 --- HDAC4 | 6-((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl)-N-hydroxyhexanamide | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dibromo-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| PKCA --- NPKC delta | 18-(1,4-oxazinan-4-ylmethyl)-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione | Drug Info |
| VEGFR2 --- TEK | N-[19-methyl-3-(2-methylpropyl)-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl]thiophene-2-carboxamide | Drug Info |
| HDAC1 --- HD6 | 3-(3-(4,5-dimethyl-1-(2-morpholinoethyl)-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | (2-Benzyl-1H-benzoimidazol-5-yl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,5R)-2-((S)-4-hydroxy-benzoylamino)-4-hydroxymethyl-cyclopentyl ester | Drug Info |
| VEGFR2 --- TEK | 7-acetyl-3-ethyl-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| HDAC1 --- HD6 | 2,2,2-trifluoro-1-(2-(indoline-1-carbonyl)thiazol-5-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | 4-(2-Methoxymethyl-pyrrolidin-1-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PKCA --- NPKC delta | Benzolactam-V8 | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | 3-(3-(4-benzyl-5-methyl-1-(2-morpholinoethyl)-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyanoquinolin-6-yl)-4-(2-(methoxymethyl)pyrrolidin-1-yl)but-2-ynamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(3-methoxyphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(pyridin-4-ylmethyl)-2-(1-(3-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
| PPAR gamma --- LXRalpha | 2-(5-((3-(8-(trifluoromethyl)quinolin-4-yl)phenyl)methylamino)naphthalen-1-yl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-imidazole-2-carboxamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-(4-{[(1-phenyl-methanoyl)-amino]-methyl}-phenyl)-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N4-(3-bromophenyl)-N6-methylquinazoline-4,6-diamine | Drug Info |
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