Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | 2-ethoxy-3-(1-((2-(4-isopropylphenyl)-5-methyloxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-p-tolyl-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-1-tert-butyl-3-[1-(cyclopentylamino)-7-mercapto-1-oxoheptan-2-yl]urea | Drug Info |
| Erbeta --- ER | ethyl 5-hydroxy-2-(4-hydroxyphenyl)benzo[d]oxazole-7-carboxylate | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-ethyl-2-(oxazol-2-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| PR --- mRNA of AR | 4,6,8,8-Tetramethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| HDAC1 --- HDAC4 | (E)-3-(5-((E)-3-(2,4-Dichlorophenyl)-3-oxoprop-1-enyl)-furan-2-yl)-N-hydroxyacrylamide | Drug Info |
| Erbeta --- ER | (2S,3S)-2-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-thiophen-2-yl-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(1-(cyclohexylmethyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| PR --- mRNA of AR | 9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| HER2 --- MMP-2 | (5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperidine-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| Erbeta --- ER | 3'-Ethylamino-[1,1';2',1'']terphenyl-4'-carbaldehyde oxime | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-ethoxy-3-(7-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-4-yl)propanoic acid | Drug Info |
| PR --- mRNA of AR | 9-chloro-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| JAK2 --- STK1 | SID103904525 | Drug Info |
| Erbeta --- ER | 7,9-Dihydroxy-5-oxa-11-thia-benzo[b]fluoren-10-one | Drug Info |
| PPAR gamma --- PPAR delta | {3-[4-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-butoxy]-phenoxy}-acetic acid | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(4-(trifluoromethyl)phenyl)-1-(3-fluorophenyl)propan-1-one | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-bromophenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 1-(4-Fluoro-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | [2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenoxy]acetic acid | Drug Info |
| PR --- mRNA of AR | 9-Fluoro-2,2,4-trimethyl-5-[1-o-tolyl-meth-(Z)-ylidene]-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| JNK1 --- JNK3 | 2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-yl)acetamide | Drug Info |
| Erbeta --- ER | (6S,6aR,10aS)-2-hydroxy-6-(4-hydroxyphenyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-8(9H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-[4-{[(4-trifluoromethyl-2-[4-trifluoromethylphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid | Drug Info |
| PR --- mRNA of AR | N-[2-(7-Methoxy-furo[2,3-c]pyridin-3-yl)-ethyl]-acetamide | Drug Info |
| JNK1 --- JNK3 | 5-cyano-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | [2-(4-Hydroxy-phenyl)-6-methyl-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-chloro-2-phenoxyphenoxy)butoxy)-2-fluorophenyl)propanoic acid | Drug Info |
| PR --- mRNA of AR | 7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline-9-carbonitrile | Drug Info |
| JNK1 --- JNK3 | N2-cyclohexyl-9-cyclopentyl-N8-(2-fluorophenyl)-9H-purine-2,8-diamine | Drug Info |
| Erbeta --- ER | 4-[1,2-bis(4-hydroxyphenyl)hex-1-enyl]phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(7-methoxy-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
| Renin --- Cathepsin D | (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(pent-1-ynyl)phenyl)-1H-imidazol-5(4H)-one | Drug Info |
| JNK1 --- JNK3 | SID103905545 | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)-6-hydroxy-1-naphthonitrile | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propyl]-amide | Drug Info |
| JNK1 --- JNK3 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)cyclopropanecarboxamide | Drug Info |
| Erbeta --- ER | (R)-9a-butyl-6-(trifluoromethyl)-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-diethyl-5,6,9a,11a-tetramethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| JNK1 --- JNK3 | N2-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-N5-propylpyridine-2,5-dicarboxamide | Drug Info |
| Erbeta --- ER | (E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-1-morpholin-4-yl-propenone | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 2-trifluoromethyl-phenyl ester | Drug Info |
| JNK1 --- JNK3 | N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-chloro-phenyl)-cyclohexyl]-amide | Drug Info |
| JNK1 --- JNK3 | methyl 4-(4-(naphthalen-2-yl)-5-oxo-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)piperidine-1-carboxylate | Drug Info |
| Erbeta --- ER | 4-Chloro-7-(3-fluoro-4-hydroxy-phenyl)-3-hydroxy-naphthalene-1-carbonitrile | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (4-bromo-2-tert-butyl-phenyl)-amide | Drug Info |
| MEP --- Cathepsin B | 3-{2-Cyano-2-[2-(2,4-difluoro-benzoylamino)-3-m-tolyl-propionylamino]-ethoxymethyl}-benzoic acid | Drug Info |
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