Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP9 --- MMP8 | {(R)-3-[(S)-2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbamoyl]-5-methyl-hexanoylaminooxy}-acetic acid methyl ester | Drug Info |
| VEGFR2 --- CSrc | 2-((4-((3-(dimethylamino)propyl)oxy)-phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-4-yl)-amide | Drug Info |
| mTOR --- AKT | N-(6-(5-(3-tert-Butylphenylsulfonamido)-6-chloropyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-1-tert-butyl-5-((4-methylpiperazin-1-yl)methyl)-1H-pyrazole-3-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(3,4-dimethoxyphenyl)urea | Drug Info |
| VEGFR2 --- CSrc | 2,6-dimethylphenyl-2,4-bis(methyloxy)phenyl(2-((4-((3-(1-piperidinyl)propyl)oxy)phenyl)amino)-4-pyrimidinyl)carbamate | Drug Info |
| Ftase --- FPTase | 5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carbonyl)-nicotinamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(2-(4-methylpiperazin-1-yl)ethyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- EGFR3 | methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylcarbamate | Drug Info |
| Ftase --- FPTase | 2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- FGFR1 | CHEMBL1762527 | Drug Info |
| Ftase --- FPTase | 2-(2,5-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 2-((2-(4-chlorophenyl)-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- TEK | 1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | Sodium salt of 2-Phosphonooxymethyl-N-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| NET --- SERT | CHEMBL353255 | Drug Info |
| VEGFR2 --- TEK | 1-(2-chlorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((2-oxo-1-phenethylpyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| NET --- SERT | 2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| VEGFR2 --- TEK | 2-methyl-3-(5-methyl-3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-isopropyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| NET --- SERT | 3-(4-Chloro-phenyl)-2-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-8-methyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| VEGFR2 --- TEK | 1-(4-methoxyphenyl)-3-[19-methyl-3-(2-methylpropyl)-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl]urea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-5H-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinomethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(4-chlorophenyl)-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-5-(3,4-dimethoxyphenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-chloro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-difluoro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | (1E,4Z,6E)-7-(4-(Hexadecyloxy)-3-methoxyphenyl)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one | Drug Info |
| VEGFR2 --- TEK | 4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclohexyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)-2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | (5-Ethanesulfonyl-2-methoxy-phenyl)-[5-(4-fluoro-phenyl)-oxazol-2-yl]-amine | Drug Info |
| FTase --- GTase | 5-[(3'-Chloro-5-cyano-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile | Drug Info |
| CCKBR --- CCKAR | N-[5-(2-Fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-4-trifluoromethyl-benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((dimethylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-3-methyl-benzenesulfonamide | Drug Info |
| H3 --- SERT | 4-(3-chlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)furan-2-yl)methylamino)acetonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-methyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(quinolin-4-ylmethyl)benzenamine | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2,3-dimethyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-nitro-benzenesulfonamide | Drug Info |
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