Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | [3-(3,4-Dihydro-2H-quinoline-1-sulfonyl)-phenyl]-bis-(3H-imidazol-4-ylmethyl)-amine | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(3-thiophen-3-yl-phenyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-8-methyl-3-(3-morpholin-4-yl-propyl)-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(4-methyl-4H-[1,2,4]triazol-3-yl)-ethyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-[4-(3'-methoxymethyl-2-methyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((4-(1-naphthoyl)-2-butylpiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(4'-cyano-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4-(2,2-dimethyl-1,3-benzodioxol-5-yl)phenyl]sulfamide | Drug Info |
| Ftase --- FPTase | [(R)-1-[(S)-1-(2-Benzyloxy-ethylcarbamoyl)-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| MMP2 --- MMP3 | (R)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-[3-(2-methyl-biphenyl-4-yl)-propyl]-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 1-(3-Chloro-phenyl)-9-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-6,7-dihydro-5H-pyrido[3,2,1-ij]quinolin-3-one | Drug Info |
| MMP2 --- MMP3 | (R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-6-(4-propyl-phenyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[2-fluoro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | (S)-2-(2-(((2S,3R)-3-methyl-2-(2-(1-(pyridin-4-ylmethyl)-1H-imidazol-4-yl)acetamido)pentyl)(naphthalen-1-ylmethyl)amino)acetamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-{4-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-phenylsulfanyl}-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-5-phenyl-9-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3,3-dimethyl-butan-1-one | Drug Info |
| MMP2 --- MMP9 | (R)-2-[5-(4-Methoxy-phenyl)-thiophene-2-sulfonylamino]-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(4-methoxyphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | [(S)-1-[(4-Benzyloxy-benzyl)-(phenethylcarbamoyl-methyl)-carbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(4-(methylsulfonyl)piperazin-1-yl)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-1-(4-(3-(dimethylamino)propyl)-1-(2-fluoro-5-methylphenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)ethanone | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-pyridin-4-yl-propan-1-one | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(5-morpholino-5-oxo-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)pentan-2-yl)formamide | Drug Info |
| FGFR --- VEGFR | N*7*-(4-Diethylamino-butyl)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-4-propoxy-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(2-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethyl)formamide | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-5-isopropoxy-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | Acetic acid (6aR,6bS,9S,10aR,12aS)-5-hydroxy-1,3-dimethoxy-6b,10,10,12a-tetramethyl-3,6,6a,6b,7,8,9,10,10a,11,12,12a-dodecahydro-1H-2,13-dioxa-benzo[a]cyclopenta[h]anthracen-9-yl ester | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-trifluoromethyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | 2-(3-Bromo-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-2-(N-(4-phenoxyphenyl)methan-15-ylsulfonamido)acetamide | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(3-(4-hydroxypiperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| Ftase --- FPTase | [[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-3-sulfonyl)-amino]-acetic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-(2,3-dihydrobenzo[b]-[1,4]dioxine-6-sulfonamido)3-methylbutyryl)-1,4-diazepan-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(4-(4-(2-aminopropan-2-yl)phenyl)-5-chloropyrimidin-2-ylamino)phenyl)ethanol | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3,5-Difluoro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-3-Phenyl-2-[4-(2-p-tolyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid | Drug Info |
| VEGFR2 --- CDK1 | 3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-6-fluoro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | 2-(7-Benzyloxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-N-hydroxy-propionamide | Drug Info |
| VEGFR2 --- Ckit | (3S,9S)-9,16-dihydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | Drug Info |
| Ftase --- FPTase | 1-(3-Chloro-phenyl)-4-[3-(2-methoxy-4'-trifluoromethyl-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one | Drug Info |
| MMP2 --- MMP9 | (R)-4-Amino-2-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-butyramide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(4-((2-(methylsulfonyl)ethylamino)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-3-yl-piperidine-1-carboxamidine | Drug Info |
| MMP3 --- MMP8 | 4-Methoxy-benzenesulfonic acid 3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl ester | Drug Info |
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