Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 3-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(trifluoromethyl)-9H-carbazole | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-morpholin-4-yl-hex-4-ynoic acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxamide | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5-dichloroisonicotinoyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-piperidine-1-carboxamidine | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(1,2-dimethyl-1H-imidazol-4-ylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-Chloro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(4-(dimethylamino)benzoyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-[2-(2-methoxy-phenyl)-1H-indol-3-yl]-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-methyl-2-(N-(pyridin-4-ylmethyl)naphthalene-2-sulfonamido)butanamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-fluoro-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-fluoro-2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-6-carboxamide | Drug Info |
| MMP2 --- MMP14 | (S)-2-{4'-[(Benzofuran-2-ylmethyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide | Drug Info |
| MMP2 --- MMP3 | (R)-2-((S)-4-(4-isopropylphenyl)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxobutan-2-ylamino)propanoic acid | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(1,3-dimethyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylsulfonyl)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)-N4-hydroxy-2-nonylsuccinamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalen-1-ylmethyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-(3,3-difluoropyrrolidin-1-yl)propyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| MMP2 --- MMP3 | [(S)-2-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-(4-phenylacetylamino-butyl)-phosphinic acid | Drug Info |
| Ftase --- FPTase | 1-(3-Benzo[1,3]dioxol-5-ylmethyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrole-3-carboxylic acid (2-methoxy-ethyl)-methyl-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine | Drug Info |
| MMP2 --- MMP3 | (6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Benzoyl-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2,5-Difluoro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorobenzyloxy)phenyl)methan-8-ylsulfonamido)-N,2-dihydroxypropanamide | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)furan-2-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Methoxy-phenylethynyl)-benzenesulfonylamino]-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-(4-phenoxy-phenyl)-methanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(3-chloro-4-fluorophenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-{4-[2-(4-methoxy-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-propionic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-4-methyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-(piperidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-benzo[1,3]dioxol-4-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(Trifluoromethyl)-3,9-dihydropyrrolo[2,3-b]carbazol-2(1H)-one | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(3'-methoxy-biphenyl-4-sulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-4-(2,5-difluorophenyl)-2-(3-(ethylamino)propyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| MMP2 --- MMP9 | 5-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-6-methyl-4-oxo-heptanoic acid | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-3-yl)-amide | Drug Info |
| DHFR --- VEGFR | (E)-5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
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