Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| NPKCdelta --- NPKCtheta | 4-(4-ethyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(3-tert-butylphenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-4-ylmethyl)aniline | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((S)-3,10-Dibromo-8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-N-m-tolyl-1,3,4-oxadiazol-2-amine | Drug Info |
| GSK --- VEGFR | Cyclopropanecarboxylic acid [6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-yl]-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid (4-{3-chloro-4-[(naphthalen-1-ylmethyl)-amino]-phenylamino}-3-cyano-7-ethoxy-quinolin-6-yl)-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(2-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)pyridin-3-yl)vinyl)-N,N-dipropylbenzenesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(4-(pyridin-4-yl)piperazin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (E)-N-(7-((R)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(3-(naphthalen-2-ylmethyl)morpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(4-isopropylphenyl)benzamide | Drug Info |
| H3 --- SERT | 7-(3-(3,3-difluoroazetidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(1-(thiazol-4-ylmethyl)-1H-indol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-m-tolylbenzamide | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-p-tolyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (R)-N-Hydroxy-7-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)heptanamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-ethyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-(2-chlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Fluorophenyl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-morpholino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chlorophenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| HD6 --- HDAC4 | (R)-2,2,2-trifluoro-1-(5-((1-phenylethylamino)methyl)thiophen-2-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PKCA --- NPKC delta | Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopropyl-1-methyl-3-(S)-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-8-yl)-amide ((S)-5-hydroxymethyl-2-isopropyl-1-(S)-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-9-yl)-amide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-2-benzyl-11-isobutyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-(3-acrylamidophenoxy)pyrimidine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3S,4R)-3-(4-hydroxy-benzoylamino)-thiepan-4-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(quinolin-3-yl)-1H-imidazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | (E)-(1S,7R,10S,21R)-7-isopropyl-21-methyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentaone | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PKCA --- NPKC delta | 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-isobutyl-5-methyl-hex-(E)-ylidene]-tetrahydro-furan-2-ylmethyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | GW549390X | Drug Info |
| HDAC1 --- HD6 | 2-(4-Methoxyphenyl)-2-oxoethyl Dithiobutyrate | Drug Info |
| EGFR3 --- HER2 | 4-Diisopropylamino-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(3-(trifluoromethyl)phenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 2-[4-(4-Chloro-phenylsulfamoyl)-phenyl]-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 2-(3-(4-Bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(5-methoxy-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{5-[(2-Phenoxy-ethylcarbamoyl)-methyl]-thiophen-2-yl}-ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidin-5-yl)-2-methyl-N-(2-morpholinoethyl)acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2,3-dimethyl-4-(2-(2-morpholinoethoxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)phenoxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-aminophenyl)nicotinamide | Drug Info |
| ER --- PR | N-(7-Bromo-1-methoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid | Drug Info |
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