Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP1 --- MMP3 | 1-{(S)-1-Benzyl-2-[4-(4-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| VEGFR2 --- TEK | 7-acetyl-19-methyl-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| MMP1 --- MMP9 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-6-hydroxy-nicotinamide | Drug Info |
| Erbeta --- ER | geldanamycin-estradiol hybrid | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-(4-methoxyphenyl)acetamide | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-pyridin-3-ylmethyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| VEGFR2 --- TEK | (S)-N-(2-(3-aminopiperidin-1-yl)-5-(trifluoromethyl)phenyl)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluorobenzamide | Drug Info |
| MMP13 --- MMP1 | 3-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-8-oxa-bicyclo[3.2.1]octane-3-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | (S)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol | Drug Info |
| VEGFR2 --- TEK | N-(2-chloro-5-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-3-isopropylbenzamide | Drug Info |
| MMP13 --- MMP1 | 1-(4-Methoxy-benzenesulfonylamino)-cyclopentanecarboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-phenyl-pyrrolo[2,1,5-cd]indolizin-5-ol | Drug Info |
| VEGFR2 --- TEK | SID124349827 | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-6-(2-(diethylamino)ethyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| Erbeta --- ER | 5'-(2-hexahydro-1-pyridinylethoxy)-2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol | Drug Info |
| VEGFR2 --- VEGFR1 | 6-Pyridin-4-yl-3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidine | Drug Info |
| MMP13 --- MMP1 | 2-((2S,5S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-5-(hydroxycarbamoyl)-6,6-dimethylthiomorpholin-2-yl)acetic acid | Drug Info |
| Erbeta --- ER | 4-Ethynyl-2-(3-fluoro-4-hydroxy-phenyl)-quinolin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(3-(4-methylpiperazin-1-yl)propyl)-3-(5-(thiophen-3-yl)pyridin-3-yl)-1H-indole | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-thiazol-4-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiine-5,7-diol | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-phenoxyphenyl)benzamide | Drug Info |
| MMP13 --- MMP8 | rac-1-(4-(but-2-ynyloxy)phenylsulfonyl)piperidine-3-thiol | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-3-phenyl-propan-1-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP2 --- HER2 | (5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperidine-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-8-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-4-methyl-benzenesulfonamide | Drug Info |
| MMP2 --- MMP1 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-(methylcarbamoyl)-ethylcarbamoyl]-5-methylhexanoyl}-N-4-methoxyphenylhydrazide | Drug Info |
| Erbeta --- Mcl1 | SID4251253 | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2,4-dimethoxyphenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| Ftase --- FPTase | 6-[(3-Chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-(4-phenoxy-phenylsulfamoyl)-benzamide | Drug Info |
| Ftase --- FPTase | 2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP2 --- MMP13 | 5-(4-Benzyloxy-phenyl)-5-methyl-pyrimidine-2,4,6-trione | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentyl-2,3-dihydrobenzofuran-5-sulfonamido)-3-methylbutanamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-propylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-(furan-3-yl)-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(2,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP13 | (S)-N-(1-cyclopropylpiperidin-4-yl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-1-oxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP3 | (S)-2-((E)-2-Hydroxycarbamoylmethyl-4-methyl-pent-2-enoylamino)-3-(1H-indol-3-yl)-propionic acid ethyl ester | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-[1,1';4',1'']terphenyl-3-carbonitrile | Drug Info |
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