Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-phenyl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-(2-morpholino-2-oxoethyl)benzenesulfonamide | Drug Info |
| FGFR --- VEGFR | N-(4-Benzyloxy-butyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-phenoxybenzonitrile | Drug Info |
| MMP2 --- MMP9 | (4S)-4-amino-5-oxo-5-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenylamino)pentanoic acid | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-7-(3-(4-methylpiperazin-1-yl)propoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 4-fluoro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(pyridin-2-ylmethylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR1 --- FGFR1 | 1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazol-4-yl)urea | Drug Info |
| Ftase --- FPTase | [(S)-4-((S)-2-Amino-2-mercapto-ethyl)-3-butyl-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP2 --- MMP9 | (S)-benzyl 2-((1-(hydroxyamino)-1-oxo-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propan-2-yl)(isopropyl)amino)ethylcarbamate | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-methoxy-1H-benzo[d]imidazol-2-yl)isoindolin-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-3-methyl-pentanoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | Succinic acid mono-[4-hydroxycarbamoyl-2-(4-phenoxy-benzoylamino)-pentyl] ester | Drug Info |
| VEGFR2 --- CDK1 | 2-(3-methoxyphenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(3-bromobenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| MMP2 --- MMP9 | (S)-3-{[4-(4-chloro-phenoxy)-phenyl]-isobutyryl-amino}-2,N-dihydroxy-propionamide | Drug Info |
| VEGFR2 --- CDK1 | 4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]butanoic acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carbothioic acid methylamide | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-N-methylbenzenesulfonamide | Drug Info |
| VEGFR2 --- Ckit | N3-(6-aminopyridin-3-yl)-4-methyl-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-2-(2-Benzyloxy-acetylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-3-((R)-Isobutyl)-4-oxo-6-((R)-phenylmethyl)-2-phenylsulfanylmethyl-heptanedioic acid 1-hydroxyamide 7-methylamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-((S)-3-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-propyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | Drug Info |
| MMP3 --- MMP8 | 7-Amino-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 4-(4-(7-(2-fluoro-4-(2-oxo-3-phenylimidazolidine-1-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-methylpiperazine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 8-Chloro-11-(1-phenylmethanesulfonyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| MMP3 --- MMP8 | (R)-2-(4-Phenoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-phenyl-2-thioxoimidazolidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(methylthiomethyl)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| MMP9 --- MMP3 | (2R,3S)-N*1*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2-(7-fluoro-naphthalen-2-ylmethyl)-3,N*4*-dihydroxy-succinamide | Drug Info |
| VEGFR2 --- CSrc | 5-Ethanesulfonyl-3-[1-{3-[3-(4-methyl-piperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| mTOR --- AKT | (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl){6-[(2R,3R)-2-(4-fluorophenyl)tetrahydrofuran-3-ylamino]-pyrazin-2-yl}methanone | Drug Info |
| VEGFR2 --- CSrc | 1-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-3-(cyclohexylmethyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| mTOR --- DNPK1 | 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one | Drug Info |
| VEGFR2 --- CSrc | CHEMBL386996 | Drug Info |
| Ftase --- FPTase | 23-oxo-4-(2-phenyl-1-ethynyl)-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | (3-(9-(1-(2,4-difluorophenyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-4'-ethoxybiphenyl-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | (3-(3-(1-benzylpiperidin-4-yl)-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)methanol | Drug Info |
| VEGFR2 --- FGFR1 | 2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,2,4]oxadiazol-3-yl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(2-chloro-6-fluoro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridazin-4-yl)urea | Drug Info |
| VEGFR2 --- FGFR1 | CHEMBL1762549 | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((Z)-1-tert-Butoxycarbonyl-2-pyridin-3-yl-vinyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea | Drug Info |
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