Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| NET --- SERT | 4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid {5-[3-(4-chloro-phenyl)-acryloylamino]-pentyl}-amide | Drug Info |
| Ftase --- FPTase | [1-(3-Benzyl-3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)furan-2-yl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3',5'-difluoro-biphenyl-3-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 3-{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)thiophen-3-yl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methoxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| PR --- mRNA of AR | 5-Bromo-2-((1S,5R)-5-hydroxy-2,2,5-trimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol | Drug Info |
| NPKCdelta --- NPKCtheta | 4-((1H-indol-5-yl)(methyl)amino)-5-(3,4-dimethoxyphenyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-((3Z,6E)-(2S,5S,8R)-8-Amino-2-benzyl-5-isopropyl-9-mercapto-nona-3,6-dienoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| PR --- mRNA of AR | 5-Bromo-4-methoxy-2-((1R,2S)-2-methyl-6-methylene-cyclohexylmethyl)-phenol | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((4-(dimethylamino)piperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cycloheptylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-phenylpropan-1-one | Drug Info |
| CAII --- CAI | 6-Hydroxy-benzothiazole-2-sulfonic acid [2-(N-methyl-guanidino)-acetyl]-amide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(piperidin-1-ylmethyl)styryl)nicotinonitrile | Drug Info |
| H3 --- SERT | (6R,10bR)-9-(3-morpholinopropoxy)-6-(thiophen-3-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| PR --- mRNA of AR | (R)-3-(4-Hydroxyphenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)-propanamide | Drug Info |
| EGFR3 --- HER2 | [3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(4-((4-hydroxypiperidin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| H3 --- SERT | (5-(4-(4-cyclopropylpiperazin-1-yl)but-1-ynyl)-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| PR --- mRNA of AR | 8-Ethyl-8-methyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-chloro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (1S,10R,11R,13S,14R)-4-diethylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester | Drug Info |
| H3 --- SERT | 1-(4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)ethanone | Drug Info |
| PR --- mRNA of AR | N-(3-Dibenzylamino-2-methyl-phenyl)-methanesulfonamide | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-(3-cyanoacetamidophenoxy)pyrimidine | Drug Info |
| PI3K gamma --- PI3K delta | Phosphoric acid (R)-2-imidazol-1-yl-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester | Drug Info |
| H3 --- SERT | 4-(4-(3-((methylamino)methyl)-4-(4-(methylthio)phenoxy)phenyl)but-3-ynyl)piperazin-2-one | Drug Info |
| PR --- mRNA of AR | 3-[(4-methoxyphenyl)phenylmethyl]indole | Drug Info |
| EGFR3 --- HER2 | 4-(3-chlorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1,3-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| HD6 --- HDAC2 | 4-(((R)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl)quinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | Drug Info |
| PR --- mRNA of AR | 8-Chloro-6-[1-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one | Drug Info |
| EGFR3 --- HER2 | 2-(2-(5-Bromo-2-hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 2-(4-hydroxy-phenoxy)-cyclopentyl ester | Drug Info |
| HDAC1 --- HD6 | (S)-3-(4-furan-2-yl-phenyl)-2-(7-hydroxycarbamoyl-heptanoylamino)-propionic acid methyl ester | Drug Info |
| Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-2,15-dioxo-4-phenyl-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(4-((isopropylamino)methyl)styryl)-6-methylpyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-acetylamino-phenyl ester | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-(3-phenoxyacetamidophenoxy)pyrimidine | Drug Info |
| PKCA --- NPKC delta | CHEMBL1794808 | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-(4-Methylphenyl)-2-oxoethyl Trithiocarbonate | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid benzhydryl-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[4-(4-benzyloxy-benzyloxy)-3-chloro-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PPAR delta --- LXRalpha | 2-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indazol-5-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | 6-((5S,11S,13aR)-5-benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanoic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 4-[2-(6-{[Bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid | Drug Info |
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