Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | 2-(3-((benzo[d]oxazol-2-yl(3-(4-hydroxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | (1R,4R,5R)-4-(2-Chloro-4-hydroxy-phenyl)-6,8,8-trimethyl-3-oxa-bicyclo[3.3.1]non-6-en-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | {2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid | Drug Info |
| JNK1 --- JNK3 | 1-acetyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-4-carboxamide | Drug Info |
| Erbeta --- ER | 4-Bromo-7-(3-fluoro-4-hydroxy-phenyl)-3-hydroxy-naphthalene-1-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | rac-2-(3-(4-Methylbenzamidomethyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| JNK1 --- JNK3 | ethyl 4-ethynyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-2,3-dihydrobenzo[b][1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-phenoxyphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-methoxyphenyl)picolinamide | Drug Info |
| Erbeta --- ER | 5R-(+)-[4-(2-dimethylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-(3-((2-methylbenzamido)methyl)phenoxy)phenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | N-[9-(3-Fluoro-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-methyl-2-(4-(3-(5-oxo-1-(1-phenylethyl)-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide | Drug Info |
| Erbeta --- ER | 2-(4-Chloro-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylamino)picolinamide | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-(4-hydroxy-phenyl)-5-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| JNK1 --- JNK3 | SID103905437 | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-p-tolyl-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| Erbeta --- ER | 5-fluoro-2-(6-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol | Drug Info |
| JNK1 --- JNK3 | N-(4-cyano-3-(thiazol-2-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide | Drug Info |
| PR --- mRNA of AR | 4,6,8,8-Tetramethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | (2S,3S)-5,7-Dihydroxy-3-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-phenylethyl)-3-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide | Drug Info |
| PR --- mRNA of AR | 9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 2,6-Dihydroxy-8-methoxy-10,11-dioxa-benzo[b]fluoren-5-one | Drug Info |
| MEP --- Cathepsin B | (S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-2-(naphthalene-1-sulfonylamino)-propionamide | Drug Info |
| PR --- mRNA of AR | 9-chloro-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-1-yl)phenol | Drug Info |
| MEP --- Cathepsin B | (S)-benzyl 1-(cyanomethylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamate | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(4-(trifluoromethyl)phenyl)-1-(3-fluorophenyl)propan-1-one | Drug Info |
| Erbeta --- ER | (S)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(4-methylpiperazin-1-yl)benzamide | Drug Info |
| PR --- mRNA of AR | 9-Fluoro-2,2,4-trimethyl-5-[1-o-tolyl-meth-(Z)-ylidene]-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 2-Phenyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(S)-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | N-[2-(7-Methoxy-furo[2,3-c]pyridin-3-yl)-ethyl]-acetamide | Drug Info |
| Erbeta --- ER | 1-(4-Chloro-phenyl)-2-(4-hydroxy-phenyl)-3H-inden-5-ol | Drug Info |
| Met --- VEGFR | 5-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one | Drug Info |
| PR --- mRNA of AR | 7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline-9-carbonitrile | Drug Info |
| Erbeta --- ER | (2S,3R)-3-Cyclohexyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | 1-tert-butyl-N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Renin --- Cathepsin D | (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(pent-1-ynyl)phenyl)-1H-imidazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 5-hydroxy-2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-1',3'-dione | Drug Info |
| Met --- VEGFR | N1-(4-(2-(1-(2-(dimethylamino)ethyl)-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamide | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propyl]-amide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-{4-[2-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-ethoxy]-phenyl}-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
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