Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Src --- VEGFR | N-(5-chloro-1,3-benzodioxol-4-yl)-5-morpholin-4-yl-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-amine | Drug Info |
| PPAR gamma --- PPAR delta | (S)-7-(3-(2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy)propoxy)chroman-2-carboxylic acid | Drug Info |
| HER2 --- CD221 | N-(4-(4-amino-1-(1'-(3-methoxypropyl)-1,4'-bipiperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | 4,4'-(3,3,3-trifluoropropane-1,2-diyl)diphenol | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-2(1H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-{3-[(3,4-Bis-trifluoromethyl-benzoyl)-(2-cyclopropyl-3-[1,2,4]oxadiazol-3-yl-phenyl)-amino]-propyl}-phenoxy)-2-methyl-propionic acid | Drug Info |
| HER2 --- MMP-2 | (2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 4-(1-Phenethyl-1,7a-dihydro-pyrrolo[2,1,5-cd]indolizin-2-yl)-phenol | Drug Info |
| VEGFR2 --- Beta PDGFR | 9-Chloro-2-({5-[3-(dimethylamino)propyl]-2-isopropylphenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]-benzazepine-6-thione | Drug Info |
| PPAR gamma --- PPAR delta | (E)-2-(2-Methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)butyl)phenoxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | 4-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(2-(dimethylamino)ethyl)benzamide | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-8-hydroxy-4-(4-hydroxyphenyl)-1,3a,4,9b-tetrahydrocyclopenta[c]chromen-2(3H)-one | Drug Info |
| VEGFR2 --- CDK1 | N-(3-chlorophenyl)-6-(5-{[3-(piperidin-1-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(2-Morpholinopyrimidin-5-yl)-5-(4-(trifluoromethoxy)-phenyl)oxazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(phenethylamino)picolinamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-(4-Allyl-piperazin-1-yl)-6-{[3-(4-chloro-phenyl)-propyl]-methyl-amino}-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| VEGFR2 --- CDK1 | 3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridine | Drug Info |
| PPAR gamma --- PPAR delta | (R)-5-(3-(3-(4-(4-fluoro-3-methylphenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (6S,6aR,11aS)-6-(4-hydroxyphenyl)-6,6a,7,8,9,10,11,11a-octahydrocyclohepta[c]chromen-2-ol | Drug Info |
| VEGFR2 --- Ckit | N-Cyclopropyl-4-methyl-3-(1-((2-(4-morpholino)ethyl)amino)-6-phthalazinyl)benzamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-6-fluoro-4-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-p-tolyl-3H-inden-5-ol | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(4-(dimethylcarbamoyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(4-(3-(1-(4-methylbenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-methoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | SID14730617 | Drug Info |
| VEGFR2 --- Cmet | (R)-N1-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-ethoxy-3-[4-(3-[1,1';3',1'']terphenyl-5'-yl-allyloxy)-phenyl]-propionic acid | Drug Info |
| JNK1 --- JNK3 | 3-(2-(4-(2-Methyl-2H-tetrazol-5-yl)phenylamino)pyrimidin-4-yl)-5-morpholinobenzonitrile | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(3,5-dimethyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| VEGFR2 --- Cmet | 5-amino-N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6,7-difluoro-2-oxoquinolin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (3S,10S,13S,17S)-3,17-dihydroxy-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde | Drug Info |
| VEGFR2 --- CSrc | 2-((3,5-dimethoxy)-4-((2-(4-morpholinyl)ethyl)oxy)phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| JNK1 --- JNK3 | ethyl 4-cyano-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | 2,2,2-Trifluoro-1-[7-hydroxy-4-(4-hydroxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-5-isopropoxy-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| JNK1 --- JNK3 | methyl 4-methyl-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | 3-(3-fluoro-4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| VEGFR2 --- CSrc | 4-methyl-3-(1-(6-(2-(4-methylpiperazin-1-yl)ethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| JNK3 --- MAPK | 2-Hydroxy-N-[2-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-ylamino)-1-((S)-phenylmethyl)-ethyl]-acetamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| VEGFR2 --- CSrc | 4-methyl-3-(1-(4-(3-(4-methylpiperazin-1-yl)propylamino)-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| MEP --- Cathepsin B | 1-((3-fluorophenyl)(p-tolyl)methylene)thiosemicarbazide | Drug Info |
| Erbeta --- ER | 5-ethyl-7-hydroxy-3-(4-hydroxyphenyl)-3H-quinazoline-4-thione | Drug Info |
| VEGFR2 --- FGFR1 | N-[2-(3-tert-Butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-N-(5-hydroxy-pentyl)-acetamide | Drug Info |
| MEP --- Cathepsin B | SID90419368 | Drug Info |
| Erbeta --- ER | (S)-2,3-Bis(4-hydroxyphenyl)propanenitrile | Drug Info |
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