Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 8-Bromo-7-hydroxy-3-(4-hydroxy-phenyl)-naphthalene-1-carbonitrile | Drug Info |
| MMP13 --- MMP1 | 8-bromo-4-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido)-N-hydroxyquinoline-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,5-bis-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-6-(2-hydroxyethyl)-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6-Dimethylaminomethyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid diethylamide | Drug Info |
| Erbeta --- ER | rac-9a-ethyl-6-methyl-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| MMP13 --- MMP1 | 4-[4-(4-Cyano-phenoxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 6-Methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-4-(3,4,5-trimethoxy-phenylamino)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 2-(3-butoxy-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-thiazol-2-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2-Bromo-4-chloro-5-methoxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 4-[6-(Isobutyl-methyl-amino)-4-phenyl-pyridin-2-yl]-phenol | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-2-({4-[4-(3-dimethylamino-propylamino)-but-2-ynyloxy]-benzenesulfonyl}-methyl-amino)-N-hydroxy-3-methyl-benzamide | Drug Info |
| Lck --- Src | 5-(4-Phenoxy-phenyl)-7-(4-piperidin-1-yl-cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Erbeta --- ER | (S)-5-[3-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| MMP2 --- HER2 | (1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (DL)-3-fluoro-4'-(methylsulfinyl)-4-(trifluoromethyl)biphenyl | Drug Info |
| Erbeta --- ER | 4-bromo-2-(3-fluoro-4-hydroxyphenyl)-7-methoxybenzo[d]oxazol-5-ol | Drug Info |
| MMP2 --- MMP1 | (S)-N-hydroxy-2,2-dimethyl-4-(4-(3,4,5-trimethoxyphenoxy)phenylsulfonyl)thiomorpholine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-4,5-dihydroisoxazolo[5,4-d]pyrimidin-6-yl)propyl)-4-methylbenzamide | Drug Info |
| Erbeta --- Mcl1 | SID24840723 | Drug Info |
| MMP2 --- MMP13 | 2-(Biphenyl-4-sulfonylamino)-6-morpholin-4-yl-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(1,1,2-triphenylethylthio)ethanamine | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3-hydroxy-phenylethynyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-methyl-2-(N-(2-morpholinoethyl)naphthalene-2-sulfonamido)butanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | Drug Info |
| Ftase --- FPTase | 2-[(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]-isoindole-1,3-dione | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-(1-methoxy-2-methyl-1-oxopropan-2-yloxy)-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | (S)-4-Carbamoyl-2-({(S)-2-[(S)-2-(3-3H-imidazol-4-yl-propionylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)-N-methyl-N-((3-methylisoxazol-5-yl)methyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N,6-triethyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(4'-fluorobiphenyl-2-yl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N-ethyl-5-(2-hydroxyethyl)-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | (2S)-2-(2'-methyl-5-((pyridin-3-yloxy)methyl)biphenyl-2-ylcarboxamido)-4-(methylthio)butanoic acid | Drug Info |
| MMP2 --- MMP13 | 2-(4-Benzoyl-piperazine-1-sulfonyl)-N-hydroxy-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(S)-5-[3-(4-acetyl-piperazin-1-yl)-propyl]-3-(2,5-difluoro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (20S)-19,20,22,23-Tetrahydro-21-methyl-19-oxo-5H,21H-18,20-ethano-12,14-etheno-6,10-methenobenz[d]imidazo[4,3-l][l,6,9,13]oxatriazacyclononadecosine-9-carb onitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4'-(1H-imidazol-2-yl)-biphenyl-4-yl]-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-3-(3-dimethylamino-propyl)-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-(3,5-difluoro-benzyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide | Drug Info |
| Ftase --- FPTase | (3-Bromo-phenyl)-[1-(3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-methanone | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-2-((R)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2-chloro-10H-phenothiazin-10-yl)-3-(phenethylamino)propan-2-ol | Drug Info |
| Ftase --- FPTase | 17-methyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP3 | (R)-2-[3-(2-chloro-biphenyl-4-yl)-propyl]-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-succinamide | Drug Info |
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