Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (S)-2-[(S)-2-((S)-2-{2-[Hydroxy-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphinoyloxy]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyrylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(naphthalene-2-sulfonamido)acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-acetyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | 2-Benzylamino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(cyclohexylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Phenyl-6-methyl-N-(4-fluorophenyl)-4,7-dihydro-2Hpyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 25 (FTI-2297) | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-1-(tert-butylamino)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829422 | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,5-difluoro-benzylamino)-benzonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-1-(4-amino-4-oxobutylamino)-3-cyclohexyl-1-oxopropan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-5-methyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Chloro-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP3 | N-((5-benzyl-2,4,6-trioxo-hexahydropyrimidin-5-yl)methyl)-4-((2-methylquinolin-4-yl)methoxy)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-2,2-dimethyl-propan-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-({(S)-2-[(S)-2-(2-3H-Imidazol-4-yl-acetylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-N*1*-hydroxy-3-isobutyl-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-benzyl-3-(3-hydroxyphenyl)-6-morpholino-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-7-pyridin-4-yl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-(2-trifluoromethoxy-phenyl)-methanone | Drug Info |
| MMP2 --- MMP9 | 2-[7-(3,5-Dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Phenyl-6-methyl-N-(3-chloro-4-fluorophenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-(3H-Imidazol-4-yl)-ethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(1-(2-hydroxyethoxy)-3-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)propan-2-yl)formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-N-(3-hydroxypropyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | (S)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one | Drug Info |
| MMP2 --- MMP9 | N-(3-Hydroxycarbamoyl-1-hydroxymethyl-butyl)-4-phenoxy-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-6-phenoxy-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(15-(pyridin-3-yl)-N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-((5-((1-(2-chlorophenyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-[7-(4-methoxy-phenoxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-propionamide | Drug Info |
| Src --- VEGFR | CHEMBL198752 | Drug Info |
| Ftase --- FPTase | 4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-6-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenoxy-benzenesulfonylamino)-propionic acid | Drug Info |
| VEGFR1 --- FGFR1 | N-(cyclohexylmethyl)-3-(5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazol-5-amine | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(3-phenoxy-phenoxy)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-[4-(4-methylsulfanyl-benzoylamino)-benzenesulfonylamino]-butyric acid | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(3-(4-ethylpiperazin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-(benzo[d]thiazol-2-yl)-2-methyl-2-phenylpropanoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CD135 | N-{4-[3-amino-1-(2-morpholin-4-yl-ethyl)-1H-indazol-4-yl]-phenyl}-N'-(3-methylphenyl)urea | Drug Info |
| Ftase --- FPTase | Sodium salt of (1,1-Difluoro-4,8,12-trimethyl-2-oxo-trideca-3,7,11-trienyl)-phosphonic acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-oxoimidazolidine-1-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-N-(3-bromophenyl)-5-chloropyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(1-((R)-tetrahydrofuran-2-yl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)ethyl)formamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(thiophen-2-yl)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-Acetyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tolylethynyl-phenylsulfanyl)-butyric acid | Drug Info |
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